New drug AZD0780 aims to lower blood pressure in heart patients

NCT ID NCT06692764

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug called AZD0780 in 202 people with heart disease or related risks and high LDL cholesterol. Participants took either the drug or a placebo for 4 weeks, and researchers measured changes in blood pressure using a 24-hour monitor. The goal was to see if AZD0780 can safely lower blood pressure in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD0780
What this could lead to: If successful, AZD0780 could offer a new way to lower blood pressure in people with heart disease and high cholesterol, potentially reducing heart attack and stroke risk.
What could go wrong: This is a small, early Phase II study with only 202 participants. Results may not apply to everyone, and the drug may not prove effective or safe in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Contacts and locations

Locations

Research Site

Inglewood, California, 90301, United States
Research Site

Northridge, California, 91325, United States
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Pomona, California, 91767, United States
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Boca Raton, Florida, 33434, United States
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Hialeah, Florida, 33012, United States
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Jacksonville, Florida, 32216, United States
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Miami, Florida, 33122, United States
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Miami, Florida, 33165, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33174, United States
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Ocala, Florida, 34474, United States
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Port Orange, Florida, 32127, United States
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Tamarac, Florida, 33321, United States
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Chicago, Illinois, 60621, United States
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Potomac, Maryland, 20854, United States
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New Bedford, Massachusetts, 02740, United States
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New Windsor, New York, 12553, United States
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Beavercreek, Ohio, 45431, United States
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Horsham, Pennsylvania, 19044, United States
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Spartanburg, South Carolina, 29303, United States
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Austin, Texas, 78704, United States
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Dallas, Texas, 75230, United States
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El Paso, Texas, 79905, United States
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Hurst, Texas, 76054, United States
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Mesquite, Texas, 75149, United States
Research Site

Paris, Texas, 75462, United States

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