Can extremely low cholesterol save more hearts? new trial aims to find out
NCT ID NCT07615296
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two cholesterol-lowering strategies in 6,000 Chinese patients with very high-risk heart disease. One group aims for ultra-low LDL cholesterol below 1.0 mmol/L, while the other targets a moderate level of 1.0-1.39 mmol/L. Researchers will track heart attacks, strokes, and deaths over up to 5 years, along with safety and cost. The goal is to see if pushing cholesterol extremely low offers extra protection without unacceptable side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lipid-lowering therapy (statins, ezetimibe, PCSK9 inhibitors)
What this could lead to
If successful, this could show that pushing LDL cholesterol extremely low provides better protection against heart attacks and strokes for high-risk patients, potentially changing treatment guidelines.
What could go wrong
This is an early-stage trial with no results yet. Ultra-low LDL-C may increase risks like cognitive decline or bleeding, and the benefit may not outweigh these risks. The study is also limited to Chinese patients, so results may not apply globally.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Anzhen Hospital, Capital Medical University
Beijing, Beijing Municipality, 100029, China
Contact Phone: •••-•••-•••• Email: •••••@•••••