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Cholesterol combo pill shows promise for High-Risk hearts

NCT ID NCT05761444

Completed Disease control Sponsor: Organon and Co Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether adding ezetimibe to atorvastatin (a common cholesterol drug) works better than atorvastatin alone in people at very high risk for heart attacks or strokes. Researchers enrolled 137 adults with atherosclerotic cardiovascular disease and measured how much their LDL (bad) cholesterol dropped after 6 weeks. The goal was to see if the combination pill helps more patients reach their cholesterol target.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ezetimibe and atorvastatin combination tablet
What this could lead to
If it works, this could support using a combination pill as a standard early treatment to better control cholesterol in people at very high risk of heart problems.
What could go wrong
This is a small, completed Phase 4 trial (137 people) that only measured short-term cholesterol changes, not long-term heart attack or stroke prevention. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Contacts and locations

Locations

  • Chonnam National University Hospital

    Gwangju, Jeollanam-do, 61469, South Korea

  • Eunpyeong St. Mary's Hospital

    Seoul, Eunpyeong-gu, 03312, South Korea

  • Inje University Ilsan-Paik Hospital

    Goyang-si, Gyeonggi-do, 10380, South Korea

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Keimyung University Dongsan Medical Center

    Daegu, Gyeongsangbuk-do, 42601, South Korea

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Ulsan University Hospital

    Ulsan, Gyeongsangnam-do, 44033, South Korea

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