New pill aims to unclog arteries in heart disease patients

NCT ID NCT07303777

Recruiting now Disease control Sponsor: Atom Therapeutics Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new daily pill called ABP-745 in 200 adults with atherosclerosis (hardening of the arteries from plaque buildup). Participants will take either a low, medium, or high dose of ABP-745 or a placebo for 52 weeks. The main goal is to see if the drug can reduce the amount of plaque in the arteries compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABP-745 (tablet)
What this could lead to: If successful, this could point toward a new daily pill to shrink artery plaque and lower heart attack risk.
What could go wrong: This is an early Phase 2 trial with only 200 people. The drug may not reduce plaque more than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerotic cardiovascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASCVD ASCVD MANAGEMENT ATHEROSCLEROSIS CARDIOVASCULAR DISEASE

Contacts and locations

Locations

Beijing Friendship Hospital, Capital Medical University
NOT_YET_RECRUITING

Beijing, China
Cardiovascular Institute of San Diego INC
NOT_YET_RECRUITING

San Diego, California, 91911, United States
Cardiovascular Research Foundation of Southern California
NOT_YET_RECRUITING

Beverly Hills, California, 90210, United States
Cognivus
NOT_YET_RECRUITING

Wahroonga, Australia
Core Research Group Pty Ltd
NOT_YET_RECRUITING

Brisbane, Australia
Dalian Second Hospital
NOT_YET_RECRUITING

Dalian, China
Guangdong Province Hospital
NOT_YET_RECRUITING

Guangzhou, China
Huashan Hospital Fudan University
NOT_YET_RECRUITING

Shanghai, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, China
Jinan Central Hospital
NOT_YET_RECRUITING

Jinan, China
Nanjing Drum Tower Hospital
NOT_YET_RECRUITING

Nanjing, China
NovaTrails
NOT_YET_RECRUITING

Newcastle, New South Wales, 2290, Australia
Peking Union Medical College Hospital
NOT_YET_RECRUITING

Beijing, China
Peking University First Hospital
NOT_YET_RECRUITING

Beijing, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, China
Renmin Hospital of Wuhan University
NOT_YET_RECRUITING

Wuhan, China
Shaanxi Provincial People's Hospital
NOT_YET_RECRUITING

Xi'an, China
Shanghai General Hospital
NOT_YET_RECRUITING

Shanghai, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, China
The Affiliated Hospital of Xuzhou Medical College
NOT_YET_RECRUITING

Xuzhou, China
The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, China
The First Affiliated Hospital of Xian Jiaotong University
NOT_YET_RECRUITING

Xi'an, China
The First Affiliated Hospital of Zhejiang University school of medicine
NOT_YET_RECRUITING

Hangzhou, China
The Lundquist Institute
NOT_YET_RECRUITING

Torrance, California, 90502, United States
The Second Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITING

Xi'an, China
The Zhongshan Hospital Affiliated to Fudan University
RECRUITING

Shanghai, China
Tianjin General Hospital
NOT_YET_RECRUITING

Tianjin, China
UniSC Clinical Trials (Brisbane)
NOT_YET_RECRUITING

Brisbane, Australia
University of the Sunshine Coast Clinical Trials Unit - Morayfield
NOT_YET_RECRUITING

Morayfield, Queensland, 4506, Australia
Washington University School of Medicine, St.louis
NOT_YET_RECRUITING

St Louis, Missouri, 63130, United States
Wuxi People's Hospital
NOT_YET_RECRUITING

Wuxi, China
Xuanwu Hospital Capital Medical University
NOT_YET_RECRUITING

Beijing, China
Zhejiang Provincial People's Hospital
NOT_YET_RECRUITING

Hangzhou, China

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