New pill aims to unclog arteries in heart disease patients
NCT ID NCT07303777
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new daily pill called ABP-745 in 200 adults with atherosclerosis (hardening of the arteries from plaque buildup). Participants will take either a low, medium, or high dose of ABP-745 or a placebo for 52 weeks. The main goal is to see if the drug can reduce the amount of plaque in the arteries compared to placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ABP-745 (tablet)
What this could lead to
If successful, this could point toward a new daily pill to shrink artery plaque and lower heart attack risk.
What could go wrong
This is an early Phase 2 trial with only 200 people. The drug may not reduce plaque more than placebo, and side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Friendship Hospital, Capital Medical University
NOT_YET_RECRUITINGBeijing, China
Contact
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Cardiovascular Institute of San Diego INC
NOT_YET_RECRUITINGSan Diego, California, 91911, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cardiovascular Research Foundation of Southern California
NOT_YET_RECRUITINGBeverly Hills, California, 90210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cognivus
NOT_YET_RECRUITINGWahroonga, Australia
Contact
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Core Research Group Pty Ltd
NOT_YET_RECRUITINGBrisbane, Australia
Contact
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Dalian Second Hospital
NOT_YET_RECRUITINGDalian, China
Contact
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Guangdong Province Hospital
NOT_YET_RECRUITINGGuangzhou, China
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Huashan Hospital Fudan University
NOT_YET_RECRUITINGShanghai, China
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Jiangsu Province Hospital
NOT_YET_RECRUITINGNanjing, China
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Jinan Central Hospital
NOT_YET_RECRUITINGJinan, China
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Nanjing Drum Tower Hospital
NOT_YET_RECRUITINGNanjing, China
Contact
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NovaTrails
NOT_YET_RECRUITINGNewcastle, New South Wales, 2290, Australia
Contact
Contact Email: •••••@•••••
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Peking Union Medical College Hospital
NOT_YET_RECRUITINGBeijing, China
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Peking University First Hospital
NOT_YET_RECRUITINGBeijing, China
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Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, China
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Renmin Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, China
Contact
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Shaanxi Provincial People's Hospital
NOT_YET_RECRUITINGXi'an, China
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Shanghai General Hospital
NOT_YET_RECRUITINGShanghai, China
Contact
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Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITINGHangzhou, China
Contact
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The Affiliated Hospital of Xuzhou Medical College
NOT_YET_RECRUITINGXuzhou, China
Contact
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The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, China
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The First Affiliated Hospital of Xian Jiaotong University
NOT_YET_RECRUITINGXi'an, China
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The First Affiliated Hospital of Zhejiang University school of medicine
NOT_YET_RECRUITINGHangzhou, China
Contact
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The Lundquist Institute
NOT_YET_RECRUITINGTorrance, California, 90502, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Second Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITINGXi'an, China
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The Zhongshan Hospital Affiliated to Fudan University
RECRUITINGShanghai, China
Contact
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Tianjin General Hospital
NOT_YET_RECRUITINGTianjin, China
Contact
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UniSC Clinical Trials (Brisbane)
NOT_YET_RECRUITINGBrisbane, Australia
Contact Email: •••••@•••••
Contact
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University of the Sunshine Coast Clinical Trials Unit - Morayfield
NOT_YET_RECRUITINGMorayfield, Queensland, 4506, Australia
Contact
Contact
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Washington University School of Medicine, St.louis
NOT_YET_RECRUITINGSt Louis, Missouri, 63130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Wuxi People's Hospital
NOT_YET_RECRUITINGWuxi, China
Contact
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Xuanwu Hospital Capital Medical University
NOT_YET_RECRUITINGBeijing, China
Contact
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Zhejiang Provincial People's Hospital
NOT_YET_RECRUITINGHangzhou, China
Contact