Cerebral atherosclerosis

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in the brain's arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their arteries scanned with a special MRI. The goal is to see if the plaques…

This study tests whether dulaglutide, a once-weekly diabetes injection, can improve blood flow in the brains of people with severely narrowed arteries. About 130 participants who recently had a mini-stroke or mild stroke will receive either standard care or dulaglutide plus stand…

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

This trial compares two blood-thinning drugs—aspirin and cilostazol—to see which one better prevents major heart and blood vessel events in people with type 2 diabetes who are already at high risk. About 1,200 participants will be randomly assigned to take one of the two medicati…

This study uses advanced 3D-rotational angiography to track how fatty plaques in brain arteries change over one year in 140 people who have had a stroke or mini-stroke. Participants will have two scans 12 months apart while managing heart risk factors. The goal is to understand p…

This study looks at fatty buildup in brain arteries that can break off and cause strokes. Researchers want to see if high-risk plaques look different from harmless ones. They will use special imaging to compare plaques in 140 people who have had a stroke with those who have not.

This study is building a biobank of blood, spinal fluid, and tissue samples from 500 Chinese adults, including stroke patients, their families, and healthy volunteers. Researchers will analyze the samples to find genetic markers linked to stroke and its complications. The goal is…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…