Heart plaque showdown: combo pill vs. super statin
NCT ID NCT06767345
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two approaches to stabilize fatty plaque in heart arteries: a moderate-dose statin plus ezetimibe versus a high-dose statin alone. Over 400 adults with coronary artery disease will be followed for a year, using advanced ultrasound to measure plaque changes. The goal is to see if the combination therapy works as well as the stronger statin, potentially offering a safer option.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rosuvastatin and ezetimibe
What this could lead to
If successful, this could show that a moderate statin combined with ezetimibe is just as good as a high-dose statin at stabilizing artery plaque, potentially offering a gentler option for heart disease patients.
What could go wrong
This is a Phase 4 trial with 408 participants, so results are still limited. The study focuses on imaging changes, not directly on preventing heart attacks, and the combination therapy might not prove superior or even non-inferior to the standard high-dose statin.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Korea University Anam Hospital
RECRUITINGSeoul, Seoul, 02841, South Korea