New drug duo aims to slash heart disease risk by targeting hidden cholesterol

NCT ID NCT06813911

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study tests whether adding pelacarsen to inclisiran can further lower a type of cholesterol called Lp(a) in people with heart disease. About 340 adults with high Lp(a) and LDL-C will receive either pelacarsen or a placebo, plus inclisiran. The main goal is to see if Lp(a) levels drop after 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pelacarsen (TQJ230) and inclisiran
What this could lead to: If successful, this could provide a new treatment option for people with heart disease who still have high cholesterol despite current therapies.
What could go wrong: This is a Phase 3 trial, but it is still experimental. The drug may not lower Lp(a) enough or could cause side effects. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD)

Contacts and locations

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AB Clinical Trials
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Las Vegas, Nevada, 89119, United States

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Aa Mrc Llc
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Flint, Michigan, 48504, United States

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Advocate Lutheran General Childrens Hospital
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Park Ridge, Illinois, 60068, United States

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American Health Network Research Dept
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Muncie, Indiana, 47304, United States
American Health Network Research Dept
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Muncie, Indiana, 47304, United States

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Anderson Medical Research
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Ft. Washington, Maryland, 20744, United States

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Baptist Health South
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Miami, Florida, 33173, United States

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Cardiovascular Associates Research
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Covington, Louisiana, 70433, United States

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Clinical Research Inst of Arizona
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Sun City West, Arizona, 85375, United States

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Excel Medical Clinical Trials LLC
ACTIVE_NOT_RECRUITING

Boca Raton, Florida, 33434, United States
FC Site Partners Miami
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Winter Park, Florida, 32789, United States

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FXM Clin Res Miramar LLC
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Miramar, Florida, 33027, United States

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Flourish Research Bowie
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Bowie, Maryland, 20715, United States

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Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Inpatient Research Clinical LLC
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Miami Lakes, Florida, 33014, United States
Intermountain Medical Center
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Murray, Utah, 84107, United States

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Interv Cardiology Med Grp
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West Hills, California, 91307, United States

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Jacksonville Center for Clinical
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Jacksonville, Florida, 32216, United States

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K2 Medical Research LLC
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Maitland, Florida, 32751, United States
Kelsey Seybold Research Foundation
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Houston, Texas, 77030, United States

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Latin Clinical Trial Center Inc
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San Juan, 00909, Puerto Rico

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MyMichigan Medical Center Midland
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Midland, Michigan, 48670, United States

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National Heart Institute
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Beverly Hills, California, 90211, United States

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Northwest Houston Clinical Research PLLC
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Tomball, Texas, 77375, United States

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Novartis Investigative Site
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Tullahoma, Tennessee, 37388, United States

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Novartis Investigative Site
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Yinchuan, Ningxia, 750004, China
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Jining, Shandong, 272000, China
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Xian, Shanxi, 710061, China
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Beijing, 100730, China
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Shanghai, 200025, China
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Béziers, 34525, France
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Cholet, 49325, France
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Grenoble, 38043, France
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Lille, 59037, France
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Montpellier, 34295, France
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Paris, 75013, France
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Pessac, 33604, France
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Poitiers, 86021, France
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Toulouse, 31054, France
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Stuttgart, Baden-Wurttemberg, 70376, Germany
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Potsdam, Brandenburg, 14473, Germany
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Chemnitz, Saxony, 09113, Germany
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Leipzig, Saxony, 04103, Germany
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Berlin, 10789, Germany
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Bielefeld, 33604, Germany
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Gelnhausen, 63571, Germany
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Mannheim, 68165, Germany
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Münster, 48145, Germany
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Singen, 78224, Germany
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Hong Kong, Hong Kong, 999077, Hong Kong
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Hong Kong, 999077, Hong Kong
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Ancona, AN, 60020, Italy
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Caserta, CE, 81100, Italy
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Grosseto, GR, 58100, Italy
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Milan, MI, 20138, Italy
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Rozzano, MI, 20089, Italy
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Perugia, PG, 06129, Italy
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Pordenone, PN, 33170, Italy
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Salerno, SA, 84131, Italy
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Legnago, VR, 37045, Italy
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The Hague, South Holland, 2545 AA, Netherlands
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Enschede, 7512KZ, Netherlands
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Santiago Compostela, A Coruna, 15706, Spain
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Pamplona, Navarre, 31008, Spain
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Castilleja de la Cuesta, Sevilla, 41950, Spain
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A Coruña, 15006, Spain
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Barcelona, 08023, Spain
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Córdoba, 14004, Spain
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Huelva, 21080, Spain
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Las Palmas GC, 35010, Spain
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Salamanca, 37007, Spain
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Valencia, 46010, Spain
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Valencia, 46014, Spain
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Changhua, 50006, Taiwan
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Kaohsiung City, 80756, Taiwan
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Tainan, 704, Taiwan
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ACTIVE_NOT_RECRUITING

Taipei, 10002, Taiwan
Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Taipei, 11217, Taiwan
Novartis Investigative Site
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Chichester, West Sussex, PO19 6SE, United Kingdom
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London, EC1M 6BQ, United Kingdom
Novartis Investigative Site
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London, W12 0HS, United Kingdom
Novartis Investigative Site
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Manchester, M13 9WL, United Kingdom
Novartis Investigative Site
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Tyne and Wear, NE29 8NH, United Kingdom
Ocala Cardiovascular Research
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Ocala, Florida, 34471, United States

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Omega Clinical Research
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Metairie, Louisiana, 70006, United States

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Overlook Medical Center
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Summit, New Jersey, 07901, United States

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Parkway Medical Center
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Birmingham, Alabama, 35215, United States

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Peace River Cardiovascular Center
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Port Charlotte, Florida, 33952, United States

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PharmaTex Research LLC
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Amarillo, Texas, 79106, United States

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SEC Clinical Research
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Pensacola, Florida, 32503, United States

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The Corvallis Clinic P C
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Corvallis, Oregon, 97330, United States

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University Of South Florida
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Tampa, Florida, 33612, United States

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University of Miami Hospital
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Miami, Florida, 33136, United States

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Virginia Heart
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Falls Church, Virginia, 22042, United States

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Wake Forest University Baptist Medical Center
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Winston-Salem, North Carolina, 27157, United States

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