Could a single daily pill slash heart disease risks?
NCT ID NCT06930885
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
The EPOCA trial is testing whether a daily 'polypill' (combining blood pressure, cholesterol, and blood-thinning medications) plus the anti-inflammatory drug colchicine can reduce major heart and limb events in people with established heart disease. Over 7,700 participants aged 45 and older with a history of heart attacks, strokes, or artery blockages will be followed for several years. The goal is to see if this simpler, combined approach lowers the risk of cardiovascular death, heart attack, stroke, urgent artery procedures, and leg amputations better than current treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
A combination pill containing valsartan (blood pressure drug), atorvastatin (cholesterol drug), and aspirin (blood thinner), plus the anti-inflammatory drug colchicine.
What this could lead to
If successful, this could provide a simple, once-daily pill regimen that significantly lowers the risk of heart attacks, strokes, and limb amputations in people with established heart disease.
What could go wrong
This is a large Phase 3 trial, but the polypill and colchicine are already approved drugs, so the main question is whether combining them works better than current standard care. Side effects like muscle pain, bleeding, or stomach issues are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CIPES - Centro Internacional de Pesquisa Clínica
RECRUITINGSão José dos Campos, São Paulo, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CMEP - Centro Multidisciplinar de Ensino especializado e Pesquisa
RECRUITINGJoinville, Santa Catarina, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro de Pesquisa Cardiolima
RECRUITINGTeresina, Piauí, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro de Pesquisa Cetrus
RECRUITINGSão Paulo, São Paulo, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro de Pesquisas Clínicas Dr. Marco Mota
RECRUITINGMaceió, Alabama, 57051160, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Empresa Brasileira de Serviços Hospitalares - EBSERCH - Hospital de Ensino Dr. Washington Antônio de Barros- HU-UNIVASF
RECRUITINGPetrolina, Pernambuco, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fundação Faculdade Regional de Medicina São José do Rio Preto
RECRUITINGSão José do Rio Preto, São Paulo, 15.090-000, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fundação Técnico Educacional Souza Marques
RECRUITINGRio de Janeiro, Rio de Janeiro, 22.793-140, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fundação Universitária de Cardiologia - ICFUC
RECRUITINGPorto Alegre, Rio Grande do Sul, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hcor
RECRUITINGSão Paulo, São Paulo, 04004-030, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitário São Francisco na Providência de Deus
RECRUITINGBragança Paulista, São Paulo, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Instituto de Pesquisa e Ensino em Saúde - IPES
RECRUITINGPorto Velho, Rondônia, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Secretária da Saúde do Estado do Ceará - Hospital de Messejana Dr. Carlos Alberto Studart Gomes
RECRUITINGMessejana, Ceará, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••