Could a higher dose of letrozole unlock fertility for women with PCOS?

NCT ID NCT07759518

Completed Disease control Sponsor: Mst.Sumyara Khatun Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial is testing whether a higher dose of the fertility drug letrozole (10 mg) works better than the standard lower dose (5 mg) for stimulating ovulation in infertile women with polycystic ovary syndrome (PCOS). About 86 women aged 18-35 with PCOS will take one of the two doses for five days each cycle, for up to three months. Researchers will track follicle growth, ovulation, and pregnancy rates to see if the higher dose improves outcomes without increasing side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: letrozole (an aromatase inhibitor used to stimulate ovulation)
What this could lead to: If the higher dose works better, it could offer a more effective oral option for women with PCOS struggling to conceive, potentially improving ovulation and pregnancy rates.
What could go wrong: This is a small, early-stage trial, and the higher dose may not prove more effective or could increase side effects. Results may not apply to all women with PCOS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PCOS

Contacts and locations

Locations

Bangladesh Medical University

Dhaka, 1000, Bangladesh

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