University Of Alberta

This early-stage trial will test an experimental vaccine against hepatitis C (HCV) in 27 healthy adults. The main goal is to see if the vaccine is safe and to measure the immune response it triggers. Participants will receive three shots over 24 weeks and be closely monitored for…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This platform trial will enroll 1,000 adults with heart failure to test several different treatments at the same time. Participants are randomly assigned to either an experimental intervention or standard care. The main goal is to see if these treatments can prevent death or hosp…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study looks at whether a common heart valve procedure called TAVI is safe when done in hospitals that don't have heart surgery available on-site. About 600 people with severe aortic stenosis will be randomly assigned to have TAVI either with or without surgical backup. The g…

This study tests a nerve-monitoring device that alerts surgeons when a child's vocal cord nerve is at risk during throat, chest, or heart surgery. About 90 children under 18 will be randomly assigned to standard care or standard care plus the monitor. After surgery, doctors will …

This study compares a yeast-based protein supplement to whey protein (from milk) to see if it can help build muscle just as well. Seventy-two healthy adults aged 18-35 who already do resistance training will take either yeast or whey protein for 16 weeks while continuing their wo…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tests a new way to treat a fast-growing blood cancer called BCR-ABL positive B-cell acute lymphoblastic leukemia. About 80 adults will receive two drugs: ponatinib pills and blinatumomab injections under the skin. The goal is to see if this combination can control the …

This study compares two CPR methods for newborns with cardiac arrest: a new technique that combines chest compressions with sustained lung inflation versus the standard 3:1 compression-to-ventilation ratio. Researchers will enroll 554 newborns across multiple hospitals to see whi…

This study tests whether a monthly injection called Tezepelumab can help adults with severe asthma avoid repeated emergency room visits and asthma attacks. One hundred participants will receive either the drug or a placebo for 90 days, followed by an open-label extension. The goa…

This study aims to find the best material to cover a small drainage device used in glaucoma surgery. Glaucoma is a leading cause of blindness due to high pressure in the eye. The researchers will compare three different patch materials (donor sclera, cornea, and pericardium) in 1…

This pilot study will test whether an AI-assisted ultrasound device can help emergency doctors quickly detect heart failure in patients with symptoms. About 84 adults visiting the ER with signs of heart failure will be enrolled. The goal is to see if this approach is practical an…

This study looks at whether starting physical therapy two weeks after cervical spine surgery helps adults with degenerative myelopathy recover walking, balance, and strength better than waiting six weeks. Twenty participants will be randomly assigned to start rehab at either two …

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. The drink is given three times a day for five days. Researchers will measure changes in heart stress markers and symptoms. The goal is to see if ketones can improve energy for t…

This study tests whether caffeine can improve breathing in newborns with meconium aspiration syndrome, a condition where babies inhale their first stool into their lungs. Twenty babies who still need oxygen support at 10-14 days old will receive either caffeine or a placebo. Rese…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This study tests whether a medication called dexmedetomidine can help patients in the intensive care unit (ICU) sleep more restfully. Good sleep is important for recovery, but ICU conditions often disrupt it. About 50 adult ICU patients will either receive the medication or a pla…

This study tests whether giving a mild electrical stimulation to the nerves during mastectomy surgery can help restore sensation to the breast and nipple. Thirty women having both breasts removed and reconstructed will receive the stimulation on one breast only, and their sensati…

This study looks at whether teaching mindfulness skills to pregnant women admitted to the hospital for risk of preterm delivery can reduce their depression, anxiety, and stress. Researchers will enroll 60 mothers and provide four weeks of mindfulness training. Participants will f…

This study tests a vibrating device to reduce pain during laser treatment for diabetic eye disease. About 50 people will have one eye treated with the device and the other without, then rate their pain. The goal is to see if the vibration helps make the procedure more comfortable…

This study compares health resources translated by professional translators versus artificial intelligence. Researchers will ask 576 parents who speak Mandarin, Punjabi, Tagalog, or Urdu to evaluate how clear and useful each translation is. The goal is to see if AI can make healt…

This observational study will look at how often very low birth weight babies in Canadian NICUs get ventilator-associated pneumonia (VAP) and how these infections are treated. Researchers will compare different hospitals' approaches to diagnosis and care, with the goal of creating…

This pilot study tests a mobile app called PAUSE that helps people with chronic conditions like diabetes or heart disease know which medications to pause when they get sick. About 320 patients from 16 pharmacies in Alberta will use the app or receive standard guidance. The goal i…

This study looks at whether inhaling nitric oxide can improve how well the lungs exchange oxygen during exercise in people with mild to moderate COPD. Researchers will measure lung blood vessel function and breathing efficiency in 80 participants (40 with COPD and 40 healthy volu…

This study will collect information from 100,000 critically ill patients worldwide who receive continuous renal replacement therapy (CRRT), a type of kidney dialysis, in intensive care units. Researchers want to understand how CRRT is used and how it affects patient survival and …

This study tests a small, handheld device called the Wellvii VitalDetect that lets patients check their blood pressure, pulse, and temperature at home after surgery. About 69 adults will use the device twice daily for two weeks and compare results with clinic measurements. The go…

This study looks at the best amount of oxygen to give babies born between 32 and 35 weeks right after birth. Researchers will compare giving 60% oxygen versus 30% oxygen to over 1,500 babies in Alberta hospitals. The goal is to see which level helps babies breathe better and need…

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with chronic kidney disease (stages 3B-5). Participants will try four different 10-day diets, all provided for free, to see which foods …

This study aims to develop and test artificial intelligence (AI) tools to help doctors prescribe and deliver acute dialysis better for patients in intensive care. Researchers will analyze data from 7,500 patients to create algorithms that can predict the best treatment approaches…