University Of Alberta

This early-stage trial tests an experimental vaccine designed to protect against hepatitis C virus (HCV). The study will enroll 27 healthy adults aged 18-45 to check if the vaccine is safe and triggers a strong antibody (germ-fighting) response. Participants will receive injectio…

This study tests a new way to treat a fast-growing blood cancer called B-cell acute lymphoblastic leukemia that has a specific gene change (BCR-ABL). About 80 adults will get two drugs: ponatinib pills and blinatumomab injections under the skin. The goal is to see if this combina…

This study looks at which type of patch works best in glaucoma surgery to lower eye pressure. Researchers will compare three materials (donor sclera, cornea, and pericardium) in 180 adults having a PreserFlo MicroShunt procedure. The goal is to find the patch that leads to fewer …

This study tests whether giving a heart medication called dobutamine early, before signs of heart failure appear, can help newborns with HIE (a brain injury from lack of oxygen at birth). Forty babies receiving standard cooling therapy will be randomly assigned to get either the …

This study compares two CPR methods for newborns who are not breathing and have no heartbeat. The standard method uses 3 chest compressions for every 1 breath. The new method gives a long breath while doing chest compressions. The goal is to see which method reduces death rates. …

This study will test a self-balancing exoskeleton called XoMotion-R in 16 people with spinal cord injury (SCI) who have some movement in their legs. The device allows users to walk hands-free, which could help those with limited arm function. Researchers want to see if it is safe…

This study tests whether starting Tezepelumab, a monthly injection, in the emergency room helps adults with severe asthma recover faster and avoid future attacks. About 100 adults aged 18-55 who use high-dose inhalers will get either Tezepelumab or a placebo alongside standard ca…

This study tests whether a yeast-based protein supplement can build muscle as effectively as whey protein in healthy adults aged 18-35 who already do resistance training. Over 16 weeks, 72 participants will take either yeast or whey protein while exercising. The main goal is to c…

This study tests a mobile app that gives people with diabetes, heart disease, or kidney disease simple guidance on when to temporarily stop certain medications during illnesses like the flu or stomach bug. The goal is to prevent serious complications such as low blood sugar or ki…

This study looks at whether a common heart valve replacement procedure (TAVI) is safe when done in hospitals that do not have heart surgery available on-site. Currently, the standard is to have surgery backup available. The trial will enroll 600 people with severe aortic stenosis…

This study will test several different treatments for heart failure at the same time to see which ones work best. About 1000 adults with heart failure will take part. The main goal is to reduce deaths and hospital stays due to heart problems.

This study tests a new pessary that is custom-shaped to fit each woman's body, aiming to be more comfortable and easier to use than standard ones. About 43 women who already use a traditional pessary will try the new design for 3 months and report on their symptoms and comfort. T…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Researchers will compare walking speed, endurance, and balance bet…

This study tests a program called Connecting Today, which helps care home residents with moderate to severe dementia have weekly video calls with family or friends. About 320 people (80 residents and their loved ones) will take part. The goal is to see if these calls improve qual…

This study tests a vibrating device to see if it can reduce pain during laser eye treatment for diabetic retinopathy. About 50 people who need laser treatment in both eyes will take part. One eye will be treated with the vibrating device and the other without, and patients will r…

This study tests whether adding a beta-glucan moisturizing cream to standard skin care helps heal incontinence-associated dermatitis (a type of diaper rash) faster and reduces pain, itching, and burning. About 60 adults with this skin condition will receive either the cream plus …

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. Sixty participants will receive either the drink or a placebo for five days. Researchers will measure changes in heart stress markers and symptoms to see if the drink improves r…

This study tests whether a medication called dexmedetomidine can help patients in the intensive care unit (ICU) get more restful sleep. Good sleep is important for recovery, but ICU patients often sleep poorly. About 50 adults who are awake and stable will receive either the drug…

This study tests a new treatment that uses blood pressure cuffs on the arms and inflatable leg sleeves to improve blood flow to the brain in people having a stroke. The goal is to see if this approach is practical and comfortable for patients while they are being transferred to a…

This study tests whether caffeine can improve breathing in newborns who have meconium aspiration syndrome (MAS) and still need oxygen after 10–14 days. Twenty babies will receive either caffeine or a placebo. Researchers will measure oxygen levels and use lung ultrasound to see i…

This study tests whether a one-hour electrical stimulation during mastectomy surgery can help restore lost sensation in the breast and nipple. Thirty women having both breasts removed preventively will receive the stimulation on one breast only, and their sensation will be tested…

This study looks at whether teaching mindfulness skills to pregnant women who are at risk of delivering early (before 37 weeks) can help lower their stress, anxiety, and depression. About 60 mothers admitted to the hospital will take part in a 4-week mindfulness program. Research…

This study tests whether using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (from stroke or trauma). The goal is to see if this approach improves how often patients practice their exercises and their overall reco…

This study gathers data from up to 100,000 critically ill patients worldwide who receive continuous kidney dialysis (CRRT) in intensive care units. Researchers will analyze treatment patterns, patient outcomes, and differences between hospitals. The goal is to learn what works be…

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with advanced chronic kidney disease (stages 3B-5) who are not on dialysis. Participants will try four different 10-day diets, all provi…

This study checks if a small, portable device called Wellvii VitalDetect can accurately measure blood pressure, heart rate, and temperature at home after surgery. About 69 adults will use the device at home and also get standard measurements during weekly hospital visits. The goa…

This study looks at what amount of oxygen is safest for babies born between 32 and 35 weeks of pregnancy. Right after birth, these babies will get either 60% or 30% oxygen to see which helps them breathe better and need less breathing support after one hour. Over 1,500 babies in …

This study looks at whether inhaling nitric oxide can improve how well the lungs exchange oxygen during exercise in people with mild to moderate COPD. Researchers believe poor blood vessel function in the lungs may cause breathing difficulties. Eighty participants (40 with COPD a…

This study will develop and test artificial intelligence tools to help doctors prescribe and deliver acute dialysis more effectively in intensive care units. Researchers will analyze data from 7,500 patients to create a smart dashboard that guides treatment decisions. The goal is…