University Of Alberta

This is an early-stage study to test the safety and immune response of a new experimental vaccine designed to prevent Hepatitis C infection. The trial will enroll 27 healthy adults aged 18-45 who will receive injections in the arm. Researchers will monitor for side effects and ch…

This large study is a flexible testing platform designed to find better ways to manage heart failure. It will enroll 1,000 adults who are either hospitalized for worsening heart failure or are stable outpatients. The platform will test multiple treatments at once, aiming to reduc…

This study is testing whether using a special pressure sensor in the food pipe can help doctors set ventilator machines more precisely for obese patients with severe breathing failure. It will involve 30 patients who are on breathing machines, comparing personalized settings to s…

This study is testing if giving a heart medication called dobutamine very early can help newborns who have brain injury from a lack of oxygen at birth. Forty babies receiving standard cooling therapy will be randomly assigned to get either the drug or a placebo. The main goal is …

This study is testing whether a specific exercise program can help nerves regrow faster and improve muscle and bone recovery after surgery for a severe arm nerve injury (brachial plexus injury). Researchers will compare outcomes in 40 patients who either do the exercises or recei…

This study is testing a new way to treat a fast-growing blood cancer called B-ALL that has a specific genetic change (BCR-ABL). Researchers want to see if giving an immune-boosting injection under the skin (blinatumomab) along with a daily pill (ponatinib) is effective and safe f…

This study aims to see if artificial intelligence (AI) and machine learning can help doctors better manage acute dialysis for critically ill patients. It will develop computer tools to predict patient needs and complications, with the goal of improving survival and kidney recover…

This study aims to find the safest amount of oxygen to give to babies born 6-8 weeks early (32-35 weeks) right after birth. Researchers will compare giving 60% oxygen versus 30% oxygen to see which helps babies breathe better and need less breathing support in their first hour. T…

This study is testing whether a ketone supplement drink can help people who are in the hospital for a sudden worsening of heart failure. Sixty patients will receive either the ketone drink or a placebo for up to five days, in addition to their standard care. Researchers will chec…

This study is testing whether caffeine can help newborns with meconium aspiration syndrome breathe better and need less oxygen support. It will involve about 20 babies who are 10-14 days old and still need some breathing help. Researchers will measure oxygen levels and use lung u…

This study is testing a new robotic exoskeleton called the XoMotion-R that helps people with spinal cord injuries walk without needing to hold onto walkers or crutches. Sixteen participants, both in the hospital and living at home, will use the device during their rehabilitation …

This study is testing whether simple compression devices on arms and legs can help improve blood flow to the brain during stroke. Researchers want to see if these non-drug treatments can be safely used while patients are being transported to specialized stroke centers. The study …

This Canadian study is testing whether transferring healthy gut bacteria from donor stool (fecal transplant) can help control ulcerative colitis. Researchers will compare the transplant to a placebo in 85 adults with active disease to see if a larger trial is worthwhile. The goal…

This study is testing if a new monthly injection called Tezepelumab, given right in the Emergency Room, can help control severe asthma attacks and prevent people from needing to return to the ER. It will compare the injection to a placebo in 100 adults with severe asthma who come…

This study aims to determine if Transcatheter Aortic Valve Replacement (TAVR) procedures for severe aortic stenosis are equally safe and effective when performed at experienced heart centers that don't have cardiac surgery teams physically present in the same building. Currently,…

This study aims to find the best patch material for glaucoma drainage surgery. It will compare three types of donor tissue patches to see which one leads to better long-term pressure control, fewer complications, and higher patient comfort. The results will help surgeons choose t…

This study is testing a mobile app called PAUSE, designed to help people with chronic conditions like diabetes or heart disease manage their medications safely when they get sick with something like the flu. Common medications for these conditions can sometimes cause dangerous si…

This study is testing whether a medication called dexmedetomidine helps patients in the intensive care unit (ICU) get better, more restful sleep. About 50 adult ICU patients will be randomly assigned to receive either the medication or a placebo for two nights while their sleep i…

This study is testing a program called 'Connecting Today' that helps people with moderate to severe dementia living in nursing homes have video calls with their family and friends. The goal is to see if these facilitated weekly calls can reduce feelings of loneliness and improve …

This study is testing if inhaling nitric oxide can help people with Chronic Obstructive Pulmonary Disease (COPD) breathe more efficiently, especially during exercise. Researchers will enroll 80 participants, including people with mild to moderate COPD and healthy individuals, to …

This study is testing a new, personalized pessary designed using 3D printing to better fit a woman's anatomy. It aims to see if this new device is as effective as traditional pessaries at relieving symptoms of pelvic organ prolapse, while being more comfortable and easier for pat…

This study is testing whether augmented reality games can make rehabilitation more engaging for people recovering from brain injuries like stroke or trauma. Researchers want to see if turning therapy exercises into fun games helps patients stick with their treatment plans better …

This study is testing whether a brief, one-hour session of electrical stimulation during surgery can help restore normal feeling to the breast after a mastectomy and reconstruction. It will involve 30 women who are having both breasts removed to prevent cancer. Doctors will stimu…

This study is testing whether a simple vibration device can reduce the pain patients feel during a common laser eye treatment for diabetic retinopathy. Researchers will compare the pain levels in 50 patients when one eye is treated with the device and the other eye is treated wit…

This study aims to see if teaching mindfulness skills can help reduce depression, anxiety, and stress in pregnant women who are hospitalized because they are at risk of delivering their baby too early. It will involve 60 participants who will either receive weekly mindfulness coa…

This study is testing how well a home monitoring device works for people recovering from surgery. Researchers want to see if the device's measurements of blood pressure, heart rate, and temperature are as accurate as those taken in a hospital. The study will also check if patient…

This study aims to understand how the medication semaglutide affects muscle health in people using it for type 2 diabetes or weight loss. Researchers will use detailed MRI scans and fitness tests to track changes in muscle and fat in the body and heart over one year. The goal is …

This international study aims to understand how continuous kidney dialysis (CRRT) is used in intensive care units worldwide. Researchers will observe 100,000 critically ill patients receiving this life-support treatment as part of their normal care. The goal is to document curren…

This study aims to understand how potassium from fresh foods like fruits and vegetables affects the body differently than potassium from processed foods in people with advanced chronic kidney disease. Researchers will provide 48 participants with four different 10-day diets to me…

This study aims to understand how the medication semaglutide (a drug for diabetes and weight loss) affects fat stored around vital organs like the heart, liver, and kidneys in people who have both type 2 diabetes and chronic kidney disease. Researchers will use MRI scans to measu…