Could early heart support protect Brain-Injured newborns?
NCT ID NCT07406477
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy will be randomly assigned to early dobutamine or a placebo. The goal is to see if this approach can be reliably done and to gather initial data for a larger future study.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dobutamine
- What this could lead to
- If this pilot succeeds, it could lead to a larger trial that may show early heart support improves outcomes for babies with HIE.
- What could go wrong
- This is a very small, early-phase pilot study with only 40 babies. It is designed to test feasibility, not effectiveness, so it may not lead to a proven treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Royal Alexandra Hospital
Edmonton, Alberta, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.