Blood test may spare heart transplant patients from painful biopsies

NCT ID NCT04707872

Recruiting now Diagnosis Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a simple blood test called Prospera can detect heart transplant rejection as accurately as the current standard—a biopsy of the heart. Researchers will compare the blood test results with biopsy results and antibody levels in 300 heart transplant recipients. If the blood test works well, it could one day reduce the need for invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prospera blood test (donor-derived cell-free DNA)
What this could lead to: If successful, this could lead to a simple blood test that reduces the need for invasive heart biopsies to check for transplant rejection.
What could go wrong: This is an early-stage study focused on calibrating the test, not proving it works in practice. The blood test may not be accurate enough to replace biopsies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART TRANSPLANT REJECTION

Contacts and locations

Locations

Advanced Heart Failure Transplant Unit
NOT_YET_RECRUITING

A Coruña, Spain
Annette C. and Harold C. Simmons Transplant Institute, BaylorScott&White Research Institute
RECRUITING

Dallas, Texas, 75246, United States
Baptist Health Institute for Research and Innovation
RECRUITING

Little Rock, Arkansas, 72205, United States
Cardiac Transplantation Laboratory, The Victor Chang Cardiac Research Institute
NOT_YET_RECRUITING

Darlinghurst, NSW 2010, Australia
Cardiovascular Medicine, University of Utah Health
RECRUITING

Salt Lake City, Utah, 84132, United States
Columbia University Medical Center, Columbia Interventional Cardiovascular Care
RECRUITING

West New York, New Jersey, 10032, United States
Division of Cardiology, University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2R7, Canada
Heart Failure and Heart Transplant Unit, University of Bologna
NOT_YET_RECRUITING

Bologna, 40138, Italy
Institute for Clinical and Experimental Medicine - IKEM Videnska 1958/9
RECRUITING

Prague, 140 21, Czechia
Montefiore Medical Center, 3319 Rochambeau Avenue, 2nd FL
RECRUITING

The Bronx, New York, 10467, United States
Silesian Center for Heart Diseases (Ś!ąskie Centrum Chorób Serca w Zabrzu
RECRUITING

Zabrze, 41-800, Poland
Tampa General Hospital, 409 Bayshore Blvd.
RECRUITING

Tampa, Florida, 33606, United States

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