Blood test may spare heart transplant patients from painful biopsies
NCT ID NCT04707872
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether a simple blood test called Prospera can detect heart transplant rejection as accurately as the current standard—a biopsy of the heart. Researchers will compare the blood test results with biopsy results and antibody levels in 300 heart transplant recipients. If the blood test works well, it could one day reduce the need for invasive procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prospera blood test (donor-derived cell-free DNA)
What this could lead to
If successful, this could lead to a simple blood test that reduces the need for invasive heart biopsies to check for transplant rejection.
What could go wrong
This is an early-stage study focused on calibrating the test, not proving it works in practice. The blood test may not be accurate enough to replace biopsies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Advanced Heart Failure Transplant Unit
NOT_YET_RECRUITINGA Coruña, Spain
Contact
Contact Email: •••••@•••••
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Annette C. and Harold C. Simmons Transplant Institute, BaylorScott&White Research Institute
RECRUITINGDallas, Texas, 75246, United States
Contact Email: •••••@•••••
Contact
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Baptist Health Institute for Research and Innovation
RECRUITINGLittle Rock, Arkansas, 72205, United States
Contact
Contact Email: •••••@•••••
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Cardiac Transplantation Laboratory, The Victor Chang Cardiac Research Institute
NOT_YET_RECRUITINGDarlinghurst, NSW 2010, Australia
Contact Email: •••••@•••••
Contact
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Cardiovascular Medicine, University of Utah Health
RECRUITINGSalt Lake City, Utah, 84132, United States
Contact Email: •••••@•••••
Contact
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Columbia University Medical Center, Columbia Interventional Cardiovascular Care
RECRUITINGWest New York, New Jersey, 10032, United States
Contact
Contact Email: •••••@•••••
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Division of Cardiology, University of Alberta
RECRUITINGEdmonton, Alberta, T6G 2R7, Canada
Contact Email: •••••@•••••
Contact
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Heart Failure and Heart Transplant Unit, University of Bologna
NOT_YET_RECRUITINGBologna, 40138, Italy
Contact Email: •••••@•••••
Contact
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Institute for Clinical and Experimental Medicine - IKEM Videnska 1958/9
RECRUITINGPrague, 140 21, Czechia
Contact Email: •••••@•••••
Contact
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Montefiore Medical Center, 3319 Rochambeau Avenue, 2nd FL
RECRUITINGThe Bronx, New York, 10467, United States
Contact Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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Silesian Center for Heart Diseases (Ś!ąskie Centrum Chorób Serca w Zabrzu
RECRUITINGZabrze, 41-800, Poland
Contact Email: •••••@•••••
Contact
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Tampa General Hospital, 409 Bayshore Blvd.
RECRUITINGTampa, Florida, 33606, United States
Contact
Contact Email: •••••@•••••