Poop pills? no, stool transplants aim to cure recurrent c. diff

NCT ID NCT03562741

Recruiting now Disease control Sponsor: Krunal Patel Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether transplanting stool from a healthy donor into the colon can prevent recurrent C. diff infections. The procedure, done via colonoscopy, aims to restore good bacteria that keep C. diff in check. Researchers are tracking 500 people to see if this stops diarrhea from coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fecal microbiota transplantation (stool from a healthy donor)
What this could lead to: If successful, this could offer a reliable way to prevent repeat C. diff infections without relying on antibiotics.
What could go wrong: This is an observational study, not a controlled trial, so results may be less conclusive. Risks include infection from donor stool or procedure complications.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLOSTRIDIUM DIFFICILE INFECTION CLOSTRIDIUM DIFFICILE INFECTION RECURRENCE

Contacts and locations

Locations

UMass Memorial Medical Center
RECRUITING

Worcester, Massachusetts, 01655, United States

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