Could a 6-Month drug cocktail beat 9 months for brain TB?

NCT ID NCT05383742

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month therapy for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter regimen is as safe and effective at reducing disability or death.

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Conditions

The condition(s) this trial relates to.

central nervous system disorder meningeal tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOUS MENINGITIS

Contacts and locations

Locations

Barranco CRS (Site ID:11301)
NOT_YET_RECRUITING

Lima, 4, Peru
Byramjee Jeejeebhoy Government Medical College (BJMC) CRS (Site ID: 31441)
RECRUITING

Pune, 411001, India
Chiangrai Prachanukroh Hospital NICHD CRS (Site ID: 5116)
RECRUITING

Chiang Mai, 50100, Thailand
Durban International CRS (Site ID:11201)
NOT_YET_RECRUITING

Durban, 4091, South Africa
Hospital Nossa Senhora da Conceicao CRS (Site ID: 12201)
RECRUITING

Porto Alegre, 91350-200, Brazil
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site ID: 12101)
RECRUITING

Rio de Janeiro, Brazil
Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS (Site ID: 12501)
RECRUITING

Kericho, Kenya
Kilimanjaro Christian Medical Centre (KCMC) (Site ID: 5118)
NOT_YET_RECRUITING

Moshi, Tanzania
Malawi CRS (Site ID: 12001)
RECRUITING

Lilongwe, Malawi
Milton Park CRS (Site ID: 30313)
RECRUITING

Harare, Zimbabwe
Moi University Clinical Research Center (MUCRC) CRS (Site ID: 12601)
RECRUITING

Eldoret, 30100, Kenya
National Lung Hospital CRS (Site ID: 32483)
RECRUITING

Vĩnh Phúc, Hanoi, 100000, Vietnam
Nutrición-Mexico CRS (Site ID: 32078)
NOT_YET_RECRUITING

Mexico City, 14080, Mexico
Siriraj Hospital, Mahidol University NICHD CRS (Site ID: 5115)
NOT_YET_RECRUITING

Bangkok, Bangkoknoi, 10700, Thailand
Socios en Salud Sucursal Peru CRS (Site ID: 31985)
NOT_YET_RECRUITING

Lima, 15046, Peru
TB HIV Innovations and Clinical Research Foundation Corp (Site ID: 31981)
NOT_YET_RECRUITING

Cavite, 4114, Philippines
Thai Red Cross AIDS Research Centre (TRC-ARC) CRS (Site ID: 31802)
NOT_YET_RECRUITING

Bangkok, Pathumwan, 10330, Thailand
University of the Witwatersrand Helen Joseph (WITS HJH) CRS (Site ID: 11101)
NOT_YET_RECRUITING

Johannesburg, 2193, South Africa

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