Could a 6-Month drug cocktail beat 9 months for brain TB?

NCT ID NCT05383742

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated May 11, 2026 · Updated 19 times

Summary

This study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month regimen for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter treatment is just as safe and effective at reducing disability and death.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Barranco CRS (Site ID:11301)
NOT_YET_RECRUITING

Lima, 4, Peru

Contact Phone: •••-•••-•••• Email: •••••@•••••
Byramjee Jeejeebhoy Government Medical College (BJMC) CRS (Site ID: 31441)
RECRUITING

Pune, 411001, India

Contact Phone: •••-•••-•••• Email: •••••@•••••
Chiangrai Prachanukroh Hospital NICHD CRS (Site ID: 5116)
RECRUITING

Chiang Mai, 50100, Thailand

Contact Phone: •••-•••-•••• Email: •••••@•••••
Durban International CRS (Site ID:11201)
NOT_YET_RECRUITING

Durban, 4091, South Africa

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hospital Nossa Senhora da Conceicao CRS (Site ID: 12201)
RECRUITING

Porto Alegre, 91350-200, Brazil

Contact Phone: •••-•••-•••• Email: •••••@•••••
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site ID: 12101)
RECRUITING

Rio de Janeiro, Brazil

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS (Site ID: 12501)
RECRUITING

Kericho, Kenya

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kilimanjaro Christian Medical Centre (KCMC) (Site ID: 5118)
NOT_YET_RECRUITING

Moshi, Tanzania

Contact Phone: •••-•••-•••• Email: •••••@•••••
Malawi CRS (Site ID: 12001)
RECRUITING

Lilongwe, Malawi

Contact Phone: •••-•••-•••• Email: •••••@•••••
Milton Park CRS (Site ID: 30313)
RECRUITING

Harare, Zimbabwe

Contact Phone: •••-•••-•••• Email: •••••@•••••
Moi University Clinical Research Center (MUCRC) CRS (Site ID: 12601)
RECRUITING

Eldoret, 30100, Kenya

Contact Phone: •••-•••-•••• Email: •••••@•••••
National Lung Hospital CRS (Site ID: 32483)
RECRUITING

Vĩnh Phúc, Hanoi, 100000, Vietnam

Contact Phone: •••-•••-•••• Email: •••••@•••••
Nutrición-Mexico CRS (Site ID: 32078)
NOT_YET_RECRUITING

Mexico City, 14080, Mexico

Contact Phone: •••-•••-•••• Email: •••••@•••••
Siriraj Hospital, Mahidol University NICHD CRS (Site ID: 5115)
NOT_YET_RECRUITING

Bangkok, Bangkoknoi, 10700, Thailand

Contact Phone: •••-•••-•••• Email: •••••@•••••
Socios en Salud Sucursal Peru CRS (Site ID: 31985)
NOT_YET_RECRUITING

Lima, 15046, Peru

Contact Phone: •••-•••-•••• Email: •••••@•••••
TB HIV Innovations and Clinical Research Foundation Corp (Site ID: 31981)
NOT_YET_RECRUITING

Cavite, 4114, Philippines

Contact Phone: •••-•••-•••• Email: •••••@•••••
Thai Red Cross AIDS Research Centre (TRC-ARC) CRS (Site ID: 31802)
NOT_YET_RECRUITING

Bangkok, Pathumwan, 10330, Thailand

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of the Witwatersrand Helen Joseph (WITS HJH) CRS (Site ID: 11101)
NOT_YET_RECRUITING

Johannesburg, 2193, South Africa

Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

TUBERCULOUS MENINGITIS