Can a smarter surgery and antibiotic combo cure joint infections for good?
NCT ID NCT06771050
First seen Jul 27, 2026 · Last updated Jul 27, 2026
Summary
This trial compares different surgical and antibiotic approaches to treat infections in artificial hip and knee joints. It tests whether cleaning the joint while keeping the implant in place (DAIR) or replacing the joint entirely leads to better cure rates. It also examines whether adding the antibiotic rifampicin to standard care improves outcomes, and how long antibiotics should be taken after surgery. The goal is to find the most effective treatment combinations to cure these serious infections.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- surgery (DAIR or single-stage revision) and antibiotics (backbone antibiotics with or without rifampicin)
- What this could lead to
- If successful, this trial could identify the most effective surgical and antibiotic strategies to cure prosthetic joint infections, reducing the need for repeat surgeries and long-term disability.
- What could go wrong
- This is a large, pragmatic trial, but results may take years to emerge. Individual responses vary, and some treatments may not be suitable for all patients or infection types.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Bankstown- Lidcombe Hospital
NOT_YET_RECRUITINGBankstown, New South Wales, 2200, Australia
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Blacktown Hospital
RECRUITINGBlacktown, New South Wales, 2148, Australia
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Calvary Adelaide Private Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
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Campbelltown Hospital
RECRUITINGCampbelltown, New South Wales, 2560, Australia
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Counties Manukau (Middlemore Hospital)
RECRUITINGMangere East, Auckland, 2025, New Zealand
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Dandenong/Monash Hospital
NOT_YET_RECRUITINGDandenong, Victoria, 3175, Australia
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Eastern Health
RECRUITINGBox Hill, Victoria, 3128, Australia
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Fiona Stanley Hospital
RECRUITINGMurdoch, Western AustraliaA, 6150, Australia
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Flinders Medical Centre
RECRUITINGBedford Park, South Australia, 5042, Australia
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Gold Coast University Hospital
RECRUITINGSouthport, Queensland, 4215, Australia
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John Hunter Hospital
RECRUITINGNew Lambton, New South Wales, 2305, Australia
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Latrobe Regional Hospital
RECRUITINGTraralgon, Victoria, 3844, Australia
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Launceston General Hospital
NOT_YET_RECRUITINGLaunceston, Tasmania, 7250, Australia
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Liverpool Hospital
RECRUITINGLiverpool, New South Wales, 2170, Australia
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Logan Beaudesert Hospital
RECRUITINGBeaudesert, Queensland, 4285, Australia
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Mater Hospital Brisbane
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Mater Hospital Sydney ST Vincents Network
NOT_YET_RECRUITINGNorth Sydney, New South Wales, 2060, Australia
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Nepean Hospital
RECRUITINGKingswood, New South Wales, 2747, Australia
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Northern health
RECRUITINGEpping, Victoria, 3076, Australia
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Prince Charles Hospital
NOT_YET_RECRUITINGChermside, Queensland, 4032, Australia
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Prince of Wales Hospital
RECRUITINGRandwick, New South Wales, 2031, Australia
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Princess Alexandra Hospital
RECRUITINGWoolloongabba, Queensland, 4102, Australia
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Ramsay Research C/O Lake Macquarie Private Hospital
RECRUITINGGateshead, New South Wales, 2290, Australia
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Redcliffe Hospital
NOT_YET_RECRUITINGRedcliffe, Queensland, 4020, Australia
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5011, Australia
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Royal Brisbane and Women's Hospital
RECRUITINGHerston, Queensland, 4029, Australia
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Royal Perth Hospital
RECRUITINGPerth, Western Australia, 6000, Australia
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2747, Australia
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Sir Charles Gairdner Hospital
RECRUITINGNedlands, Western Australia, 6009, Australia
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St George
RECRUITINGKogarah, New South Wales, 2217, Australia
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St Vincents
RECRUITINGFitzroy, Victoria, 3065, Australia
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Sunshine Coast University Hospital
NOT_YET_RECRUITINGBirtinya, Queensland, 4575, Australia
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Sutherland Hospital
RECRUITINGCaringbah, New South Wales, 2229, Australia
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Te Toka Tumai (Auckland Hospital)
RECRUITINGGrafton, Auckland, 1023, New Zealand
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The Alfred Hospital
RECRUITINGMelbourne, Victoria, 3011, Australia
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The Canberra Hospital
NOT_YET_RECRUITINGGarran, Australian Capital Territory, 2605, Australia
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The Queen Elizabeth Hospital
RECRUITINGWoodville, South Australia, 5011, Australia
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Toowoomba Hospital- Darling Downs Health
RECRUITINGToowoomba, Queensland, 4350, Australia
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Townsville Hospital and Health Service
NOT_YET_RECRUITINGDouglas, Queensland, 4814, Australia
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University Hospital Geelong
NOT_YET_RECRUITINGGeelong, Victoria, 3220, Australia
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Waitemata (North Shore Hospital)
RECRUITINGTakapuna, Auckland, 0620, New Zealand
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Western Health
RECRUITINGFootscray, Victoria, 3011, Australia
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Westmead Hospital
RECRUITINGWestmead, New South Wales, 2145, Australia
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