New drug could save infected joint implants, avoid major surgery
NCT ID NCT06621251
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called TRL1068 for people with a long-term infection in a hip or knee replacement. The drug works by breaking down the protective layer (biofilm) that bacteria create, making antibiotics more effective. The goal is to cure the infection with a minor procedure and antibiotics, so the original implant can stay in place instead of being removed and replaced in a major two-stage surgery. About 60 adults aged 18 to 85 with a first or recurrent chronic joint infection are taking part.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Gulfcoast Research Institute
Sarasota, Florida, 34232, United States
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M3 Wake Research Associates
Wilmington, North Carolina, 28412, United States
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Mayo Clinic Jacksonville
Jacksonville, Florida, 32224, United States
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New England Baptist Hospital
Boston, Massachusetts, 02120, United States
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North Texas Medical Research Institute
Rockwall, Texas, 75087, United States
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OrthoArizona
Gilbert, Arizona, 85234, United States
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Phoenix Clinical Research
Tamarac, Florida, 33321, United States
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Sinai Hospital Baltimore
Baltimore, Maryland, 21215, United States
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UCLA
Los Angeles, California, 90024, United States
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University of Rochester
Rochester, New York, 14623, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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