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Poop pills aim to break the cycle of recurrent c. diff

NCT ID NCT07458984

Recruiting now Disease control Sponsor: Helsinki University Central Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking capsules made from healthy donor stool (fecal microbiota transplantation, or FMT) can prevent another bout of C. diff infection in people who have had it come back at least twice. 76 adults will receive either active FMT capsules or placebo, and researchers will track who gets diarrhea and a positive C. diff test within 12 weeks. The goal is to see if this simple pill approach works better than a dummy treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

fecal microbiota (healthy donor stool) in oral capsules

What this could lead to

If it works, this could offer a simple, pill-based way to prevent recurrent C. diff infections without needing antibiotics or hospital procedures.

What could go wrong

This is a phase 3 trial, but it's still relatively small (76 people). The placebo group may also show improvement, and long-term safety or effectiveness beyond 12 weeks isn't yet known.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLOSTRIDIOIDES DIFFICILE INFECTION RECURRENCE FMT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Helsinki University Hospital

    RECRUITING

    Helsinki, Uusimaa, 00290, Finland

    Contact Phone: •••-•••-•••• Email: •••••@•••••