Bacterial infectious disease

This study tested a 9-month treatment plan for people with multidrug-resistant tuberculosis (MDR-TB) in Gabon. The goal was to see if this shorter regimen could cure the disease with fewer side effects. 23 patients aged 15 and older took part, and the study tracked how many were …

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tested a new combination vaccine designed to protect healthy infants against five types of meningococcal bacteria (A, B, C, W, and Y) that can cause serious infections like meningitis. Over 700 infants received different doses or combinations of the vaccine to check sa…

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This early-stage trial tested a new vaccine (CJCV2) designed to protect against Campylobacter infection, a leading cause of foodborne illness. Fifty-nine healthy adults received three different doses of the vaccine, with or without an immune-boosting adjuvant (ALFQ). The main goa…

This study tested a new two-step vaccine approach to protect HIV-infected adults from pneumococcal infections, a common cause of serious illness in this group. The standard vaccine often doesn't work well in people with lower immune cell counts. The study involved 212 participant…

This study looked at how well the MenBVac vaccine protects children against a specific type of meningitis B bacteria. Researchers measured the immune response in 218 children who had already received five doses of the vaccine. The goal was to see if the children had enough antibo…

This study tested whether a fourth dose of the MenBVac vaccine boosts protection against meningitis B in children. Researchers measured immune responses in 120 children before and after the booster. The goal was to see if the vaccine maintains protective antibody levels over time…

This study tested new pneumococcal vaccines in over 1,300 adults aged 18 and older to see if they are safe and help the body fight off pneumococcal disease. Participants received one shot of either a new vaccine or an existing one, and were monitored for side effects and immune r…

This study tested a new vaccine called Pn-MAPS30plus to see if it is safe and helps the body fight pneumonia-causing bacteria. It involved 127 healthy adults aged 50 to 64. The vaccine is designed to protect against more types of the bacteria than current vaccines.

This study tested a new vaccine (VLA15) to prevent Lyme disease, a tick-borne illness. About 12,500 healthy people aged 5 and older in high-risk areas received either the vaccine or a placebo. The goal was to see if the vaccine safely reduces Lyme disease cases compared to no vac…

This study looked at 117 children aged 4-8 who had received four doses of the MenBVac vaccine against meningitis B. Researchers measured how many still had protective antibodies four years after the last dose. The goal was to see if the vaccine's immunity lasts over time.

This phase 3 trial tested a 13-valent pneumococcal vaccine (13vPnC) against the older 7-valent version in over 1,600 healthy infants in China. The goal was to see if the newer vaccine triggers a stronger immune response and is just as safe. Infants received four doses starting at…

This study tested a new vaccine called VLA15 to prevent Lyme disease, which is spread by tick bites. Researchers gave the vaccine or a placebo to 625 healthy people aged 5 to 65. The goal was to check safety and how well the vaccine triggers an immune response. Results showed the…

This study tested whether a new Lyme disease vaccine (VLA15) is safe for healthy children ages 5 to 17. Over 3,500 kids received either the vaccine or a placebo (saltwater shot) and were monitored for about 2 years. The main goal was to check for side effects like pain, redness, …

This Phase 3 trial tested a new anthrax vaccine called AV7909 in nearly 3,700 healthy adults. The vaccine aims to protect people after they have been exposed to anthrax bacteria. Results showed that AV7909 produced a strong immune response and was safe, similar to the current lic…

This Pfizer study tested a new 5-in-1 vaccine (MenABCWY) that targets five types of meningococcal bacteria, which can cause serious infections like meningitis. The trial involved 309 healthy teens aged 11 to 14 and compared two different dosing schedules (shots 12 months apart vs…

This study tested a new 24-valent pneumococcal conjugate vaccine (PCV24) in 385 healthy adults aged 18 and older. The goal was to check its safety and how well it triggers an immune response compared to an existing vaccine. Participants received one dose of either a low, middle, …

This study looked at whether a booster dose of the meningitis B vaccine (Bexsero) works well and is safe for healthy people aged 10 to 20. It included 312 participants who either got the vaccine as babies or had never received it. The goal was to see if the booster triggers a str…

This study tested an experimental vaccine (CssBA+dmLT) to see if it can prevent moderate-to-severe diarrhea caused by ETEC bacteria, a common cause of traveler's diarrhea. About 72 healthy adults received either the vaccine or a placebo, then were exposed to the bacteria in a con…

This study tested a new vaccine (NmCV-5) to protect infants against meningitis, a serious infection of the brain and spine. About 1,325 healthy infants in Mali received either the new vaccine or a standard one at 9 or 15 months old. The goal was to see if the new vaccine works as…

This completed Phase I/II trial tested a new 26-valent pneumococcal conjugate vaccine in 450 people aged 2 months and older. The goal was to check safety and how well the vaccine triggers an immune response compared to existing vaccines. Researchers monitored side effects and ant…

This early-stage study tested a new vaccine called LTB-SA7 designed to protect against infections caused by Staphylococcus aureus bacteria. 129 healthy adults received either the vaccine or a placebo to check for safety and to see if the vaccine triggers an immune response. The s…

This large study tested a typhoid conjugate vaccine called TyphiBEV in over 72,000 people aged 1 to 30 years in Vellore, India. The goal was to see if the vaccine reduces the number of confirmed typhoid fever cases in vaccinated communities compared to unvaccinated ones. The tria…

This study tested a new vaccine designed to protect against 25 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 220 healthy adults aged 18 to 49 received either the new vaccine or an existing one to compare safety and immune response. …

This study tested a new vaccine called V116 in 882 children and teenagers aged 2 to 17 who have a higher risk of pneumococcal disease due to conditions like diabetes or chronic lung disease. The goal was to see if V116 is as good as or better than the current vaccine PPSV23 at tr…

This study tested a new pneumococcal vaccine in 225 healthy toddlers aged 12 to 15 months. The goal was to check safety and how well the vaccine triggers an immune response. Participants received either one or two doses and were monitored for side effects and antibody levels over…

This completed Phase 3 study tested a new vaccine called V116 in 518 adults aged 18 to 64 who are at increased risk for pneumococcal disease due to conditions like diabetes or chronic lung disease. The vaccine targets 21 strains of the bacteria that cause pneumonia and other infe…

This completed study tracked over 10,000 people in Thailand who received the Boostagen® vaccine, which protects against tetanus, diphtheria, and whooping cough. Healthcare workers reported any side effects to see how safe the vaccine is in everyday use. The study also looked at p…

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study tested an experimental vaccine called H56:IC31 in 831 adults who had just finished treatment for tuberculosis (TB). The goal was to see if the vaccine could lower the chance of TB coming back. Participants were randomly assigned to get either the vaccine or a placebo, …

This study tested a new 20-valent pneumococcal vaccine (20vPnC) against an existing 13-valent vaccine in 400 adults aged 50 and older in China who had never received a pneumococcal vaccine. The goal was to check safety and immune response. Results will help decide if the broader-…

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This phase 2 trial tested the oral cholera vaccine Vaxchora in 34 healthy adults to see how well it triggers protective antibodies and immune cells. Participants received a single dose, and researchers measured antibody levels, B cells, and T cell responses. The goal is to unders…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This study looked at whether giving the meningitis B vaccine (Bexsero) and the pneumonia vaccine (PCV13) along with routine baby shots is safe and works well. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever,…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This completed phase 1b trial tested a new 13-valent pneumococcal conjugate vaccine (PCV13) in 140 healthy infants (2 months old) and children (2-5 years). The goal was to check safety and immune response compared to an existing vaccine. Researchers monitored side effects and ant…

This early-stage trial tested a new 24-valent pneumococcal conjugate vaccine in 119 healthy children aged 2 to 17. The goal was to see if the vaccine is safe and helps the body build immunity against pneumococcal bacteria, which can cause pneumonia and other serious infections. R…

This early-phase study tested a new 13-valent pneumococcal conjugate vaccine in 310 healthy volunteers ranging from 6-week-old infants to adults up to 49 years old. The goal was to check the vaccine's safety and how well it triggers the immune system to fight pneumococcal bacteri…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested a new vaccine (MenACYW) to protect against four types of meningococcal bacteria that can cause meningitis and sepsis. Over 1,500 healthy infants and toddlers in India and South Africa received the vaccine alongside routine childhood shots. Researchers compared i…

This study tested a new investigational vaccine (MenPenta) designed to protect against five types of meningococcal bacteria (A, B, C, W, Y) that cause meningitis and bloodstream infections. Around 1,200 healthy adolescents and adults received either the new vaccine or existing va…

This study tested a new vaccine called BK1310 in 370 healthy infants to see if it safely protects against several serious diseases: Hib, diphtheria, pertussis, tetanus, and polio. The vaccine was compared to existing vaccines. The goal was to check how well the infants' immune sy…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This completed Phase 3 study tested a combined vaccine called BK1310 in 33 healthy infants. The vaccine aims to protect against diphtheria, tetanus, pertussis, polio, and Hib with a series of injections. Researchers measured antibody levels to see if the vaccine triggers a strong…

This study tested a booster dose of the DTaP vaccine (BK1301) in 446 adolescents aged 11-12 who had already received the standard childhood series. The goal was to confirm the vaccine boosts immunity against diphtheria, tetanus, and pertussis (whooping cough) safely. Results show…

This early-stage trial tested a new 23-valent pneumococcal polysaccharide vaccine in 144 healthy people aged 2 and older. Participants received one dose of either the experimental or a control vaccine. The study checked for side effects and measured immune response through blood …

This study looks at whether giving the Tdap vaccine every 3 months for a year is safe for healthy plasma donors. Normally, this vaccine is given once every 10 years. The goal is to see if more frequent vaccination produces high levels of tetanus antibodies in the plasma, which co…

This study compares two ways of making sure people with tuberculosis (TB) take their medicine correctly: traditional in-person observation by a healthcare worker versus electronic observation using live video or recorded videos on a computer or phone. The trial involves 216 TB pa…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This trial investigates whether giving two different pneumonia vaccines—one followed by another a year later—boosts immune protection more than a single vaccine alone in adults who have had their spleen removed. People without a spleen are at higher risk for serious pneumococcal …

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study looks at giving the steroid hydrocortisone early to children (ages 2 months to 12 years) with septic shock. The goal is to see if it lowers the chance of death within 28 days and shortens time on blood pressure medicines and in the ICU. About 122 children will take par…

This study tested an inhaled drug called RSP-1502, which combines the antibiotic tobramycin with a substance called CaEDTA, in 71 people with cystic fibrosis who have chronic Pseudomonas lung infections. The goal was to check safety and find the right dose. Participants received …

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tested three different materials used to treat severe, irreversible tooth inflammation. 72 adults with painful molars received a procedure where the damaged pulp was removed and covered with one of the materials. The goal was to see if newer materials (TheraCal LC and …

This study looks at whether an extra cleaning step before a routine bladder check during laparoscopic hysterectomy can lower the chance of urinary tract infections after surgery. About 98 women having the surgery for non-cancer reasons will be observed. The goal is to see if this…

This study tested a single booster dose of a recombinant botulinum vaccine in 25 healthy adults who had already been vaccinated against botulism for work. The goal was to see if the booster safely raises their antibody levels enough to donate plasma for making BabyBIG, a treatmen…

This study tested an experimental drug called GSK3036656 in combination with other tuberculosis medications in 127 adults with newly diagnosed, drug-sensitive pulmonary TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to s…

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested whether a combination of topical antibiotics and antiseptic washes could reduce staph bacteria on the skin of Native American adults living on or near tribal lands. Participants were at high risk for staph infections due to diabetes, obesity, or recent infection…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested a drug called sonelokimab, given as a shot under the skin, in 422 adults with moderate to severe hidradenitis suppurativa (a painful skin condition causing boils and abscesses). Participants were randomly assigned to receive either the drug or a placebo for up t…

This study tested a drug called sonelokimab in 418 adults with moderate to severe hidradenitis suppurativa, a skin condition that causes painful lumps and abscesses. Participants received either the drug or a placebo injection for 16 weeks. The goal was to see if sonelokimab redu…

This study tested whether metformin, a common diabetes drug, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers gave low-dose metformin to 80 ICU patients with sepsis and kidney injury, monitoring for side effects and feasibility. The goal…

This study looked at whether shining a special low-level laser on the gums after getting a dental implant can reduce swelling, pain, and help the implant stay stable. Fifty adults who needed implants took part. The laser was used right after surgery, and the team checked healing,…

This study tested whether a single dose of azithromycin can eliminate meningococcal bacteria from the nose and throat of healthy college students. Over 700 students participated, and researchers checked for bacterial clearance two weeks after treatment. The goal is to find a new …

This completed study looked at 80 people with empyema, a serious lung infection. Researchers compared two different antibiotic combinations to see which was safer and more effective. The goal is to help doctors choose the best treatment for this condition.

This study tested a new drug called VR-AD-1005 for treating severe diarrhea caused by cholera. The drug aims to reduce fluid loss and the need for antibiotics, which could help fight antibiotic resistance. 150 adults with cholera took part, and researchers measured stool output a…

This study tested whether the antibiotic ciprofloxacin works as well as doxycycline for treating plague, a serious bacterial infection. Only 5 people in Uganda took part, and they were randomly assigned to one of the two drugs. The goal was to see if ciprofloxacin could be a good…

This completed Phase 1/2 trial tested a new lab-made antibody called SNA02-48 for treating tetanus in 255 Chinese adults. The study compared SNA02-48 to the standard treatment (human tetanus immunoglobulin) to see if it is safe and how well it works. The goal is to find a more re…

This study looked at whether a booster dose of typhoid vaccine given 5-6 years after the first shot still works in children. Researchers measured immune responses and side effects in 147 children in Burkina Faso. The goal is to understand how long protection lasts and if boosters…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested whether taking a probiotic called Lactobacillus crispatus LCr86 by mouth could improve vaginal health in women with an intermediate vaginal microbiome. 80 women participated, taking either the probiotic or a placebo for 8 weeks. Researchers measured changes in v…

This study tested whether giving a single high dose of vitamin B12 (5 grams) to 20 adults with septic shock is feasible and safe. Patients received either vitamin B12 or a placebo (saline) alongside standard care. The main goal was to see if the study procedures could be complete…

This trial tested a new 4-month combination of three drugs (OPC-167832, delamanid, and bedaquiline) against the standard 6-month treatment for drug-susceptible pulmonary tuberculosis. 122 adults with newly diagnosed TB took part. The goal was to see if the shorter regimen is safe…

This study tested a drug called GM-CSF in 166 ICU patients who had severe sepsis or septic shock and a weakened immune system. The goal was to see if the drug could reduce the number of new infections acquired in the ICU. Patients received either GM-CSF or a placebo, and research…

This study tested a new antibiotic combination, cefepime-zidebactam, against a standard antibiotic (meropenem) in adults hospitalized with complicated urinary tract infections or kidney infections. About 530 participants received either the new drug or the standard one for 7 to 1…

This study looked at 200 adults with multidrug-resistant Pseudomonas infections who were treated with the antibiotic combination ceftolozane-tazobactam. Researchers tracked how many patients survived at 30 days and while in the hospital, and whether follow-up cultures showed the …

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested a single dose of the drug pretomanid in 32 children with rifampicin-resistant tuberculosis (TB). The goal was to see how the drug moves through the body and whether it is safe when added to their regular TB treatment. The children were monitored for 48 hours aft…

This study tested different combinations of the acid-blocker tegoprazan with antibiotics to treat H. pylori, a common stomach infection. 640 adults who had never been treated before received one of several drug regimens for 14 days. The goal was to see which combination worked be…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study looked at how to best dose two medicines, rifapentine and isoniazid, for children aged 0-12 with latent (hidden) tuberculosis infection. The goal was to find a dose that works as well as in adults to prevent the infection from turning into active TB. The study included…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could reduce the risk of death within 28 days. 234 adults in the ICU received either vitamin C or a placebo for up to 4 days. The main goal was to…

This completed trial tested a centralized care model for patients with serious staph bloodstream infections. Over 2,500 adults in Alberta hospitals received automated alerts and expert recommendations to ensure they got the right tests, antibiotics, and specialist care. The goal …

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal wa…

This study tested a single dose of CMTX-101, an antibody designed to break up bacterial biofilms, in 43 adults with cystic fibrosis who have chronic lung infections with Pseudomonas aeruginosa. The goal was to see if adding CMTX-101 to standard inhaled antibiotics is safe and tol…

This study tested whether charcoal-infused toothbrushes remove plaque and stains better than regular nylon toothbrushes. Thirty-six Egyptian adults brushed twice daily for 4 weeks with standard toothpaste. Plaque and stain levels were measured at the start and end. The goal is to…

This study tested a structured plan to remove excess fluid early in patients with septic shock. 170 ICU patients were randomly assigned to either the fluid removal protocol or standard care. The goal was to see if the plan could safely reduce fluid buildup by day three, which mig…

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested two different doses of the antibiotic linezolid, combined with three other drugs (bedaquiline, delamanid, and clofazimine), in 138 people with drug-resistant pulmonary tuberculosis. The goal was to see which dose worked better at clearing the infection and was e…

This completed study tested whether a new drug called keverprazan, combined with the antibiotic amoxicillin, can effectively treat a first-time H. pylori infection in adults. 264 participants took either keverprazan or esomeprazole (a standard acid reducer) plus amoxicillin for 1…

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This study tested a two-drug combination—tegoprazan (a stomach acid blocker) and amoxicillin (an antibiotic)—to treat H. pylori infection, a common stomach bug that can cause ulcers. The trial enrolled 50 adults who had not been treated for H. pylori before. The goal was to see i…

This study tested whether a visual storytelling sticker on antibiotic packaging helps adults with urinary tract infections (UTIs) take all their medicine. 358 adults in Pakistan were randomly assigned to get either the sticker or usual care. The goal was to see if the sticker imp…

This study tested a device that delivers antibiotics directly to an infected hip or knee joint for 7 days after replacement surgery. 76 adults with joint infections were randomly assigned to get either the local antibiotic irrigation plus standard care, or standard care alone. Th…

This study tested whether paramedics can improve survival by giving antibiotics and fluids to sepsis patients before reaching the hospital. Over 2,000 adults with suspected sepsis and low blood pressure were enrolled. The goal was to see if early treatment in the field reduces de…

This study tested whether an inhaled antibiotic (tobramycin), taken alone or with an oral antibiotic (ciprofloxacin), can permanently clear Pseudomonas aeruginosa infections from the lungs of people with bronchiectasis. The trial involved 371 adults and compared these treatments …

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This study tested whether adding bedaquiline to two standard antibiotics (clarithromycin and ethambutol) helps clear a stubborn lung infection called MAC lung disease. 129 adults who had not responded to previous treatment took part. The main goal was to see if the new combinatio…

This study tested whether an oral antibiotic (moxifloxacin) works as well as a standard intravenous (IV) antibiotic (cefazolin) for treating moderate skin infections (cellulitis) in the emergency department. 390 patients with moderate cellulitis were treated either with daily IV …

This study tested the safety of using pHyph, a vaginal tablet that naturally restores acidity, for 12 days in 32 adult women with bacterial vaginosis (BV). BV is a common infection causing unpleasant discharge and odor, and often returns after antibiotic treatment. The goal was t…

This study tested two new antibiotic combinations (cefepime/nacubactam and aztreonam/nacubactam) against the best available treatments for adults with serious infections like urinary tract infections, pneumonia, and abdominal infections caused by carbapenem-resistant bacteria. Th…

This study tested whether taking a higher dose of the drug rifampin for 2 months is as safe and effective as the standard 4-month dose for treating latent tuberculosis (TB) infection. Over 1,300 adults and children aged 10 and older with latent TB were randomly assigned to receiv…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis. Participants had not taken HIV medication before and had been on TB treatment for less than three months. The goal was to see if th…

This study tested whether tamsulosin (Flomax) can reduce the risk of urinary retention and catheter-related infections in men aged 50 and older after elective surgery. Participants received either tamsulosin or a placebo after their catheter was removed. The goal was to see if th…

This study tested whether the antibiotic tigecycline works better than the standard drug doxycycline for scrub typhus, a bacterial infection spread by mites. Thirty-one hospitalized patients were randomly assigned to receive either tigecycline or doxycycline. Researchers measured…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This early-phase trial tested whether an injection made from human umbilical cord cells (called secretome) can help heal chronic skin ulcers in people with leprosy. 27 adults with ulcers that had not healed with standard care received the injection and were followed for 12 weeks.…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepp…

This study tested a checklist to prevent MRSA surgical site infections in over 23,000 veterans undergoing joint replacement or heart surgery. The checklist included using antibiotic ointment and antiseptic baths before surgery, plus antibiotics during surgery. Researchers measure…

This study tested whether giving three blood-pressure-raising drugs (norepinephrine, angiotensin II, and vasopressin) together early in septic shock works better than the usual stepwise approach. Researchers enrolled 79 adults with severe sepsis and low blood pressure despite flu…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This study tested whether an early, computer-guided dosing strategy for vancomycin helps children with MRSA infections reach the right drug levels faster than the usual approach. 100 children aged 1 month to 16 years took part. The goal was to improve treatment effectiveness whil…

This completed phase 4 trial tested whether taking doxycycline for 3 days works as well as the usual 7-day course for treating chlamydia. About 526 men and women with confirmed chlamydia took either a 3-day or 7-day regimen, with placebo pills used to keep the study blinded. Part…

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study looked at whether it is safe to stop giving annual azithromycin to communities with low levels of trachoma, an eye infection that can cause blindness. Over 3,900 people in Niger took part. Researchers compared stopping treatment after at least 5 years versus continuing…

This study compared two treatments for severely decayed baby molars in children aged 4 to 9. One group received a pulpotomy, where only the infected part of the tooth's nerve is removed and replaced with a special cement (Biodentine). The other group had a full pulpectomy, removi…

This study tested whether injecting the antibiotic gentamicin directly into swollen lymph nodes helps people with cat scratch disease recover faster. 75 participants received either the injection or a placebo, along with standard oral antibiotics. The goal was to see if the injec…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested different doses of the antibiotics minocycline and metronidazole, combined with bismuth and a stomach acid blocker, to treat Helicobacter pylori infections that didn't clear with previous treatments. 480 adults who had failed earlier therapy were randomly assign…

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested a new medicine called AP-SA02, given through a vein, along with standard antibiotics for adults with a Staph blood infection. The main goal was to check if the combination is safe and tolerable. Researchers also looked at whether it helped clear the infection fa…

This study looked at 121 people with heart disease who were getting a stent. Researchers checked if they also had a silent H. pylori stomach infection and whether treating that infection reduced stomach symptoms or bleeding. The goal was to see if eradicating the bug helps patien…

This pilot study tested whether adding methylene blue to standard care is feasible for adults with septic shock in the intensive care unit. The main goal was to see if a larger trial could be done, not to prove the treatment works. Fifty patients took part, and the study looked a…

This study tests whether a special donor plasma product called OctaplasLG can help people with septic shock who develop blood clotting problems. Sixty participants will receive either OctaplasLG or a placebo (salt water) to see if the treatment improves clotting and outcomes. The…

This early-stage trial tested an experimental antibiotic called GSK3882347 in 140 women with uncomplicated urinary tract infections (UTIs). Participants received either the new drug, a standard antibiotic (nitrofurantoin), or a placebo for 5 days. The study measured how well the …

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the…

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tested two different drug combinations to treat Helicobacter pylori, a stomach infection that can cause ulcers. About 400 adults took either a two-drug regimen (tegoprazan and amoxicillin) or a four-drug regimen (including bismuth and furazolidone). The goal was to see…

This large study tested whether a 'balanced' fluid (Lactated Ringer) is better than normal saline for children with septic shock. Over 9,000 kids participated across multiple hospitals. The goal was to see which fluid reduces the risk of serious kidney problems or death within 30…

This study tested whether a two-drug combination (vonoprazan plus either amoxicillin or doxycycline) works as well as the standard four-drug bismuth quadruple therapy for eradicating H. pylori infection. 579 adults with H. pylori took one of three 14-day treatments. Researchers m…

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This study tested a special wound dressing called MicroMatrix Flex on 25 adults with deep or tunneled wounds, such as pressure injuries, diabetic ulcers, or infected wounds. The goal was to see how safely and quickly the dressing helped close these wounds over 12 weeks. Researche…

This study looked at whether giving two antibiotics together (meropenem and azithromycin) helps children with drug-resistant typhoid fever get better faster than using just one. 90 children aged 6 months to 5 years with confirmed typhoid took part. The main goal was to see how qu…

This study tested whether a probiotic called WecProB could help children with mycoplasma pneumonia get better faster. Sixty children aged 6 months to 12 years took either the probiotic or a placebo. The main goal was to see if the probiotic reduced the amount of pneumonia-causing…

This study looked at how the antibiotic cefiderocol works in hospitalized infants under 3 months old with suspected or confirmed gram-negative bacterial infections. Researchers measured drug levels in the blood and checked for side effects in 30 babies. The goal was to find the r…

This study tested whether a vaccine already approved for meningitis B (Bexsero) can also protect against gonorrhea infection. Healthy men aged 18–35 received either the meningitis vaccine or a placebo, then were exposed to the gonorrhea bacteria in a controlled setting. The goal …

This large trial tested whether a lower-chloride fluid (Ringer's Lactate) reduces death and kidney injury compared to standard saline in 1,113 adults with septic shock. Participants received either fluid within 6 hours of hospital arrival. The study aims to settle a long-standing…

This study tested a rapid blood test (T2Bacteria Panel) that identifies bacteria directly from blood, compared to standard blood cultures that take 1-3 days. Researchers wanted to see if using this test could help doctors stop unnecessary vancomycin (a strong antibiotic) sooner i…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested two simpler procedures called Lesion Sterilization and Tissue Repair (LSTR) against the standard root canal treatment (pulpectomy) for infected baby molars in 66 children. One LSTR method cleaned the root canals, while the other only removed the top pulp and pla…

This study compared two treatments for pleural infection, a serious lung condition where infected fluid builds up. One group received standard fibrinolytic drugs (alteplase and DNase) to break down clots, while the other group received simple saline (salt water) irrigation to flu…

This study tested whether a stronger solution of sodium hypochlorite (5% vs 3%) works better as a wash and bleeding stopper during a partial pulpotomy—a procedure to save a tooth with deep decay and nerve inflammation. The trial involved 128 adults with painful, infected molars. …

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested whether vaginal capsules containing live lactobacilli (good bacteria) are safe and tolerable for treating bacterial vaginosis (BV), a common infection. Fifty-seven women with BV took either the lactobacillus capsules or the standard antibiotic metronidazole. The…

This study tested whether vaginal probiotic capsules can cure bacterial vaginosis (BV) better than a placebo. 402 women with BV took part. The main goal was to see if more women were cured 21-30 days after treatment with the probiotic compared to placebo. The trial was completed …

This study tested a 14-day treatment using two drugs (vonoprazan and amoxicillin) against a more complex seven-then-seven-day regimen for H. pylori infection in 337 adults in Taiwan. The goal was to see if the simpler dual therapy works just as well, with fewer side effects and e…

This study tested whether vaginal capsules containing two types of Lactobacillus probiotics can treat bacterial vaginosis, a common vaginal infection. Sixty-six women received either the probiotic capsule or a placebo. The goal was to see if the probiotics could restore normal va…

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. T…

This study tested a device that uses UVA and blue light to treat bacterial vaginosis and yeast infections. 38 women received one or two light treatments. Researchers checked if symptoms improved and if the vaginal microbiome became healthier. The goal is to find an alternative to…

This study tested whether adding a traditional Chinese herbal formula (Banxiaxiexin decoction) to standard antibiotics can better treat H. pylori infection and related indigestion. 104 adults with both conditions took either the herbal combo or standard therapy for 14 days. The m…

This study looked at using a special filling material called OrthoMTA for root canals in second baby molars that have no permanent tooth growing underneath. Thirteen children received the treatment and were checked for up to 12 months to see if the tooth stayed healthy and infect…

This study tested whether a yogurt containing LG21 probiotics can clear H. pylori infection in children aged 4-6. 140 kids were split into two groups: one ate the yogurt daily for 12 weeks, the other got no treatment. The main goal was to see if the yogurt could turn a positive s…

This study tested a lab-made antibody called 514G3 in 52 hospitalized adults with Staphylococcus aureus bloodstream infections. Participants received either a single dose of the antibody plus standard antibiotics or a placebo plus antibiotics. The main goals were to check safety …

This study tested a new antibiotic called MK-7655A in 115 children from birth to 18 years old who had serious bacterial infections. The goal was to see if the drug is safe and works better than standard treatments. Children were randomly assigned to receive either the new drug or…

This study looked at whether giving vitamin D alongside antibiotics helps premature babies with sepsis recover better. Researchers gave 78 preterm infants either antibiotics alone or antibiotics plus 400 or 800 IU of vitamin D daily for 7 days. They tracked changes in sepsis scor…

This study tested whether taking two antibiotics instead of three is just as effective for treating a lung infection called MAC, while causing fewer side effects. 474 adults with MAC lung disease were randomly assigned to receive either two or three drugs for 12 months. The goal …

This study tested whether adding an inhaled antibiotic (ALIS) to standard oral antibiotics helps adults with a new diagnosis of a hard-to-treat lung infection caused by MAC bacteria. About 425 adults took part. The main goal was to see if the combination improved breathing sympto…

This study tested whether methylene blue, a dye used in medicine, can help adults with septic shock recover faster. 88 participants received either methylene blue or a placebo for up to 5 days. The main goal was to see how quickly blood pressure stabilized without other drugs.

This study tested whether using ultrasound to guide fluid management could improve outcomes in 118 sepsis patients in the ICU. Doctors used ultrasound to check blood flow and heart function before deciding how much fluid to give. The goal was to see if this approach could lower d…

This study tested whether an older antibiotic, temocillin, works as well as the standard treatment meropenem for bloodstream infections caused by drug-resistant bacteria. 334 adults with these infections were randomly assigned to receive one of the two antibiotics for 7 to 14 day…

This study tested a less invasive treatment called vital pulp therapy against standard root canals for teeth with severe pulp inflammation. In the new approach, dentists removed only the inflamed pulp and placed a natural blood-derived material (PRF) to help the tooth heal. Forty…

This study looked at how to best use antibiotics to prevent infections in people having knee replacement surgery. About 1,770 adults were split into groups that got antibiotics either just before surgery or for a full day after. The goal was to see if a single dose works as well …

This study tested whether a combination of two antibiotics (azithromycin and cefixime) works better than azithromycin alone for treating uncomplicated typhoid fever in South Asia. Over 2,100 patients took part across Bangladesh, India, Nepal, and Pakistan. Researchers measured tr…

This study tested whether a simpler two-drug treatment (tegoprazan and amoxicillin) works better than the standard four-drug therapy for eradicating H. pylori, a bacteria that can cause stomach ulcers. 370 adults with H. pylori infection were randomly assigned to one of the two t…

This completed study in Laos tested over 1,200 adults for H. pylori, a stomach bacteria linked to cancer. Those infected received a 14-day course of antibiotics and acid-reducing medication. The study also screened high-risk participants for early signs of stomach cancer. The goa…

This study tested two common antibiotics, clindamycin and metronidazole, taken orally for a week to treat abnormal vaginal flora in pregnant women at high risk for preterm labor. The goal was to see which drug better clears the infection and reduces risks like early delivery. 166…

This study looked at whether giving antibiotics for a shorter, personalized time is as safe and effective as the usual 7-day course for full-term newborns with a suspected infection. About 488 babies took part across 18 hospitals. The goal was to see if shorter treatment could re…

This study looked at 508 adults with H. pylori infection to see if a 7-day triple therapy (vonoprazan, amoxicillin, tetracycline) works as well as a 14-day dual therapy (vonoprazan, amoxicillin). The goal was to compare how often the infection is cleared and how many side effects…

This study tested whether a low-cost food storage cabinet called a "meatsafe" could reduce diarrhea in children aged 6 to 24 months in low-income areas of Dhaka, Bangladesh. Researchers compared households that received the cabinet and food safety education to those that did not.…

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omepr…

This phase 3 trial tested two new antibiotic combinations—cefepime/nacubactam and aztreonam/nacubactam—against a standard antibiotic (imipenem/cilastatin) in 614 adults with complicated urinary tract infections or acute kidney infections. The goal was to see if the new combos are…

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tested a new skin test called C-TST to find latent (hidden) tuberculosis infections in 300 adults in Indonesia who were close contacts of TB patients. Participants received both the skin test and a standard blood test (IGRA) to see how well the new test worked. The goa…

This study tests a new radioactive tracer called [F-18]MHF to see if it can detect infections around knee implants using PET scans. Researchers will compare the tracer's uptake in infected versus non-infected implants in 18 adults. The goal is to improve diagnosis and reduce unne…

This study tested a new molecular test (iiPCR) to diagnose scrub typhus, a bacterial infection spread by mites. Researchers compared the test's accuracy against standard methods in 345 participants in Thailand. The goal was to see if this tool could provide faster, reliable diagn…

This study tested a new skin test called EC to see if it can accurately diagnose tuberculosis (TB) infection in adults aged 65 and older. Researchers compared EC with a standard TB skin test (TB-PPD) and a blood test (T-SPOT) in 780 participants, including TB patients and healthy…

This study looked at 173 adults on ventilators to see if combining advanced germ-detection tests with a patient's immune response can improve diagnosis of ventilator-associated pneumonia. Researchers compared several molecular tests and host-response markers to standard clinical …

This study compared two methods for diagnosing H. pylori infection: the rapid urease test (a simple, cheap test done during endoscopy) and a newer molecular test (PCR) that can also detect antibiotic resistance. Researchers enrolled 100 adults who needed an endoscopy. The goal wa…

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This study looked at whether an artificial intelligence (AI) tool can help doctors diagnose ventilator-associated pneumonia (a serious lung infection) in ICU patients. Researchers analyzed chest X-rays from 119 adults on breathing machines, comparing the AI's readings to doctors'…

This study looked at whether measuring TB DNA in fluid from around the lungs (pleural fluid) can quickly and accurately diagnose tuberculosis. Researchers tested fluid from 329 adults with lung fluid buildup. The goal was to see if this DNA test works better than standard tests, …

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study tested a new rapid blood test called SeroSelectTB to see if it can diagnose active tuberculosis (TB) faster than current methods. Over 9,000 adults in South Africa, Tanzania, and Ethiopia who were unwell and suspected of having TB or pneumonia took part. The goal is to…

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to …

This study tested how well cold, heat, and electric pulp tests detect tooth nerve health in 175 adults needing root canals. Researchers compared test results to direct observation of nerve bleeding during treatment. The goal was to find which test is most accurate for diagnosing …

This study tested two ways of preparing tissue samples to find bacteria in bone and joint infections. One method grinds the sample, while the other uses standard techniques. Researchers wanted to see which method is more accurate at diagnosing infections. The study involved 122 p…

This study checked how well a new rapid test (Reveal TP) detects syphilis compared to standard lab tests. About 600 adults visiting a Vancouver STI clinic took part. The goal was to see if the quick finger-prick test is accurate enough for routine use.

This study looked at whether a bronchoscopy (a thin, flexible tube with a camera) can help diagnose tuberculosis in the airways of people whose usual sputum tests came back negative. 63 adults with suspected lung TB took part. The goal was to catch the disease earlier and more ac…

This study tested a new pain scoring tool to help dentists tell apart reversible and irreversible pulpitis, a common diagnostic challenge. Researchers enrolled 143 patients with tooth pain and compared the tool's results with two standard classification systems. The goal was to s…

This study tested a new rapid test (OCEAN Dx) to identify bacteria in the blood of 110 ICU patients with suspected sepsis. The goal was to see if it works as well as standard blood cultures, which take 48-72 hours. A faster result could help doctors choose the right antibiotics s…

This study tested a new, low-cost tool called the Intensive Care Infection Score (ICIS) to see if it can better detect bacterial infections in burn patients compared to standard blood tests. Researchers studied 97 adults and children hospitalized for burns. The goal was to improv…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the pas…

This study tested whether adjusting the dose of a tuberculosis (TB) prevention drug based on a person's genetic makeup could improve treatment. Researchers enrolled 78 people and used a quick genetic test to guide the dose of isoniazid. The goal was to see if this personalized ap…

This large Phase 3 trial tested a vaccine called ExPEC9V in nearly 18,000 adults aged 60 and older who had a urinary tract infection in the past two years. The goal was to see if the vaccine could prevent invasive E. coli disease, a serious infection that can spread to the blood …

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This study looked at how well the whooping cough (pertussis) vaccine works in pregnant women with and without HIV, and whether it is safe for them and their babies. Over 500 pregnant women received the vaccine during their second or third trimester. Researchers measured antibody …

This completed trial tested a device that uses light to kill germs in the nose before surgery, aiming to prevent surgical site infections. Over 400 adults having major surgeries received either the light treatment or standard care. Researchers tracked infections and side effects …

This study tested a new way to prevent surgical site infections by using a special light treatment inside the nose just before surgery. Over 4,700 adults having major surgeries like heart, spine, or joint replacement took part. The goal was to see if this light therapy reduces in…

This completed study tested a new public health pack to find and prevent tuberculosis (TB) early in people living with someone who has TB. Over 7,400 participants in Thailand were involved. The pack included active screening, treatment for active TB, and preventive therapy for th…

This study tested whether putting the antibiotic gentamicin directly into the bladder can prevent recurrent urinary tract infections (UTIs) in postmenopausal women. Twenty women were split into two groups: one received gentamicin via a catheter into the bladder, and the other too…

This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…

This study tested whether a new vaccine against certain E. coli bacteria (ExPEC9V) can be given at the same time as a high-dose flu shot in adults aged 65 and older. The goal was to see if the immune response to both vaccines remains strong when given together. About 959 particip…

This study tested a new vaccine called MT-2301, which protects against Haemophilus influenzae type b (Hib), given together with the standard DPT-IPV vaccine (which protects against diphtheria, pertussis, tetanus, and polio). The trial involved 154 healthy infants aged 2 to 7 mont…

This study tested a new vaccine called V116 in adults aged 50 and older to see if it is safe and works better than the current vaccine (PPSV23) at preventing pneumococcal disease, which can cause pneumonia and other serious infections. About 1,500 healthy adults received either V…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested an experimental vaccine (G03-52-01) in 622 healthy adults to see if it could safely protect against botulinum toxin, the poison that causes botulism. Participants received either the vaccine or a placebo, and researchers measured side effects and immune response…

This study tested a two-step vaccine approach to prevent pneumococcal infections in 26 adults with diffuse large B-cell lymphoma who were receiving chemotherapy with rituximab. The vaccines, Prevenar and Pneumovax, were given in a prime-boost sequence to boost immune protection. …

This study tested whether using an antibacterial mouthwash every day could lower the chance of getting gonorrhea in the throat. Researchers recruited 89 HIV-positive and HIV-negative men at high risk. Participants gargled with either Listerine or a placebo mouthwash daily. The st…

This study tested a new vaccine called V116 in 313 adults with HIV to see if it safely prevents pneumococcal disease (a serious infection that can cause pneumonia and meningitis). Participants received either V116, a placebo, or an existing vaccine. The trial is complete, and res…

This study tested a special dressing coated with a spider-silk-like chemical (DACC) to see if it prevents infections after vascular surgery. Over 700 adults in the UK were randomly assigned to get either the DACC dressing or a standard one. Researchers checked for infections at 3…

This observational study followed 145 adults who received REBYOTA™ to prevent another Clostridioides difficile infection (CDI) after completing antibiotics. Researchers collected information from medical records over 6 months to see how many people stayed infection-free. The goal…

This study tested whether applying medical-grade honey after bone-anchored hearing aid surgery could prevent skin breakdown better than the usual bacitracin ointment. Seventeen adults were randomly assigned to receive either honey or bacitracin for two weeks after surgery. Resear…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study looked at four different ways to activate the cleaning solution used during root canals: laser, sonic, ultrasonic, and simple needle irrigation. The goal was to see which method causes the least pain after the procedure and how much debris gets pushed out of the tooth.…

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tests whether ALIDYA, a gel injected into the skin, can improve the appearance of cellulite on the back of the thighs. Thirty women aged 20 to 45 with mild to moderate cellulite received six weekly treatments. Researchers used photos, ultrasound, and other imaging to m…

This study looked at pain after root canal treatment using two types of sealers: bioceramic and resin. 72 adults with no pain before treatment had a single-root tooth filled. They rated their pain at 6, 24, 48, and 72 hours, and 7 days after. The goal was to see if the sealer typ…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two dru…

This study tested whether a technique called apical patency—gently passing a small file just beyond the tooth root during root canal treatment—reduces pain afterward. 150 adults with inflamed but painless teeth (asymptomatic irreversible pulpitis) were randomly assigned to receiv…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study tested whether using an ultrasonic device to clean root canals causes less pain afterward than a standard needle. 108 adults with tooth pain had root canals and were randomly assigned to one method. Pain was measured using a scale. The goal is to find which cleaning me…

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if pat…

This completed Phase 4 study tested multiple doses of Qwo, a drug made from bacterial enzymes, for treating mild to moderate cellulite in adult women. Five participants received injections in their buttocks and thighs over three sessions. The goal was to see if the treatment impr…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This study tested whether taking a combination of trypsin, bromelain, and rutoside before a root canal helps the numbing shot work better and lowers pain after the procedure. 124 adults with painful tooth inflammation (pulpitis) took the medication or a placebo. The goal was to i…

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested three biocompatible materials—TheraCal PT, Biodentin, and MTA—for reducing pain after a pulpotomy (removing the inner pulp) in 51 adults with severe toothache. Participants rated their pain before and up to 7 days after treatment. The goal is to find which mater…

This study tested whether a supervised exercise program can improve heart and lung function and quality of life in people with lasting lung damage from tuberculosis. 60 participants were split into an exercise group and a control group. The goal was to see if physical training he…

This study compared two common painkillers—diclofenac sodium and ibuprofen—for managing pain after a root canal. Sixty adults with irreversible pulpitis received one of the two drugs right after treatment, and their pain was tracked for 48 hours. The goal was to see which drug pr…

This study compared two ways to fill a root canal after treating a painful tooth infection (irreversible pulpitis). 56 people aged 18-60 took part. One group got a continuous wave condensation filling, the other a single-cone filling. Researchers measured how long each method too…

This study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…

This study tested whether injecting dexamethasone, diclofenac sodium, or chymotrypsin into the gum before numbing medicine can make dental treatment less painful. 105 men with severe toothache took part. The goal was to see if these drugs help the numbing work better so patients …

This study tested whether applying cryotherapy (ice or cold saline) during dental procedures for deep cavities reduces pain and improves quality of life. 144 adults received either a pulpotomy or root canal treatment, with or without cryotherapy. The goal was to see if the cold t…

This study looked at 146 adults with painful tooth inflammation who needed root canal treatment. It compared two different tools (WaveOne and ProTaper) to see which one leads to less pain after the procedure. Patients rated their pain at several times over a week. The goal is to …

This study tested three different rinses used during root canal treatment to see which one causes the least pain afterward. Ninety adults with tooth pain took part, and each received one of the rinses: sodium hypochlorite, hydrogen peroxide, or normal saline. Pain levels were mea…

This completed Phase 3 trial tested the antibiotic gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if symptoms like pain and urgency improved within 24 hours. Researchers measured symptom scores and safety. The …

This study tested whether a whole-body compression bandage could help reduce fluid buildup in ICU patients with severe sepsis or septic shock. 64 patients on mechanical ventilation received the bandage within 12 hours of admission. Researchers tracked daily fluid balance and chec…

This study tested a procedure called full pulpotomy (removing only the infected pulp inside the tooth crown) in 58 adults with severe toothache. It compared success in teeth with and without an infection at the root tip (apical periodontitis), using an AI tool to help detect the …

This study looked at 200 children aged 2 to 12 with mild to moderate croup, a viral infection that causes a barking cough and breathing trouble. Researchers compared giving the steroid dexamethasone as a pill versus an injection to see which works better for easing symptoms. The …

This study looked at whether women who had surgery for prolapse or incontinence could safely remove their urinary catheter at home one day after surgery, instead of waiting 3-4 days. 128 women who failed a voiding trial before leaving the hospital took part. The main goal was to …

This study tested several non-drug methods—like a textured plastic device called ShotBlocker, a vibrating ice pack (Buzzy), and a skin-tapping technique—to reduce pain from injections in children aged 4 to 6. 120 kids in a pediatric emergency department took part. The goal was to…

This study tested two medications placed inside the tooth after an emergency root canal to see which one reduces pain better. 43 adults with severe tooth pain (pulpitis) received either calcium hydroxide or Tobradex (an antibiotic-steroid combo). Pain levels were measured before …

This study tested three different root canal filling materials in 54 people with inflamed tooth pulp to see which caused the least pain after a single-session root canal. Patients rated their pain over 7 days. The goal is to find a material that makes root canals more comfortable…

This study looked at 60 adults with painful tooth inflammation (pulpitis) who needed a root canal. Researchers compared two types of sodium hypochlorite (a common disinfectant) — one made for dental use and one household bleach — to see which caused less pain after the procedure.…

This completed pilot study tested whether two biomarkers (renin and DPP3) can predict how well patients with septic shock respond to angiotensin II, a drug that raises blood pressure. Forty adults with persistent low blood pressure despite standard treatment were randomly assigne…

This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients …

This study looks at how drug-resistant bacteria, specifically ESBL-producing E. coli, are passed from mothers to their newborns during vaginal birth or scheduled C-sections. Researchers will test stool samples from 200 healthy mothers and their babies at a Chicago hospital to see…

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at how a single dose of the antibiotic levornidazole is processed by the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and urine, and monitor safety. The goal is to under…

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study examined 750 emergency patients with joint pain to find out which germs cause septic arthritis. Researchers compared standard lab cultures with a new PCR test to see which works better. The goal is to help doctors diagnose joint infections more quickly and accurately.

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This completed study monitored 1560 adults hospitalized with invasive pneumococcal infections (excluding meningitis) across France. Researchers collected information on infection severity, risk factors, and bacterial serotypes to understand how these infections occur and how vacc…

This study compared staph bacteria from 57 patients with implant infections to 31 from healthy nasal carriers. Researchers looked at the bacteria's genes and ability to form biofilms (slimy coatings). The goal was to find what makes some staph strains more dangerous around implan…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This completed phase 1 study tested whether giving healthy adults a controlled dose of whooping cough bacteria via nasal spray can safely cause mild infection. The goal was to establish a human infection model for future vaccine and treatment research. 79 participants aged 18-40 …

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This pilot study looked at how well the antibiotic azithromycin kills Mycobacterium avium complex (MAC) bacteria in the lungs during the first 14 days of treatment. Ten adults with MAC lung disease took azithromycin daily, and researchers measured bacterial levels in their sputum…

This study looked at 526 adults with sepsis who had normal blood pressure to see if a simple measure called the diastolic shock index (DSI) and a blood test for lactate could predict which patients would need medication to support their blood pressure within 6 hours. Researchers …

This study followed 39 travelers to Southeast Asia to see if their guts naturally clear a type of antibiotic-resistant E. coli (ESBL E. coli) over time. Participants provided stool samples before and after travel and up to a year later. The goal was to understand how the body's o…

This completed study reviewed medical records of 203 adults hospitalized with Haemophilus influenzae pneumonia across 13 hospitals. Researchers aimed to find factors linked to early relapse (within 90 days) and severe outcomes like intensive care or death. By analyzing patient da…

This completed study looked at antibiotic resistance in bacteria causing urinary tract infections (UTIs) in Uganda. Researchers compared resistance patterns in patients who sought care at community drug shops versus hospitals. By studying 890 participants, they aim to understand …

This study looked at 58 full-term newborns with suspected early-onset sepsis to find early clinical signs that could help doctors tell if a bacterial infection is present. Researchers reviewed medical records from 2013 at a single hospital. The goal was to improve diagnosis and a…

This completed study looked at 104 adults in the ICU with severe pneumonia caused by three common bacteria. Researchers checked whether the bacteria were sensitive to amoxicillin/clavulanic acid (AMC) or to third-generation cephalosporins (3GC), which are standard treatments. The…

This study looked at health records from over 5,000 adults to see if having an H. pylori stomach infection is linked to metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. Researchers compared people with and without the in…

This study tested whether a specific ultrasound-based algorithm could help doctors better manage fluids in patients with septic shock. The trial involved 136 intensive care patients and compared the algorithm to standard care over the first 4 days. The goal was to see if the algo…

This completed study looked at people with genetic conditions that affect how the lungs clear mucus, such as cystic fibrosis and primary ciliary dyskinesia. Researchers examined 87 participants, including healthy volunteers, to understand why these patients get repeated lung infe…

This study looked at whether measuring hepcidin, a hormone that controls iron levels, in the blood of 114 patients with severe sepsis or septic shock could predict who would die within 28 days. Researchers also tracked deaths at 90 days and infections acquired in the hospital. Th…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study examined whether the standard dose of isoniazid, a key tuberculosis drug, is right for all adults. Researchers measured drug levels in 112 patients to see if some were getting too much or too little. The goal was to understand how individual differences in drug process…

This large study in rural Ethiopia looked at whether providing clean water, sanitation, and face-washing education can reduce trachoma infections in communities that have already received many rounds of antibiotics. Over 47,000 people from 40 communities took part. The goal is to…

This study tested a new drug called MK-7762 in 119 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo in single or multiple doses. The goal was to check for side effects and measure drug levels in the blood, not t…

This study looked at how a new drug called OPC-167832 is processed by the liver when taken with other common medicines. Twenty-four healthy adults took part to see if certain drugs slow down or speed up the breakdown of OPC-167832. The goal was to gather safety information, not t…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…

This study looked at whether alcohol consumption affects the success of local anesthesia for people with a painful tooth condition called irreversible pulpitis. Researchers gave 70 patients (35 who drink alcohol and 35 who don't) a standard numbing injection and measured pain dur…

This study looked at how immune cells in the lungs respond to tuberculosis (TB) proteins in 17 adults—some with latent TB (no symptoms) and some never exposed. Researchers used a thin tube to deliver the protein directly into the lung and collected cells to measure immune reactio…

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked at 343 adults with infections in their artificial hip or knee joints. It compared two common surgeries: one-stage (removing and replacing the joint in one operation) and two-stage (removing the joint, treating the infection, then replacing it later). The main go…

This study looked at 56 patients in a French hospital who had infections from a rare type of Klebsiella pneumoniae bacteria that can be treated with the common antibiotic amoxicillin. Researchers used genetic sequencing to understand why these bacteria are sensitive to amoxicilli…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study looked at 36 adults with painful tooth nerve inflammation (irreversible pulpitis) to see if biological markers in gum fluid match symptoms. Researchers collected gum fluid samples before and after root canal treatment and measured pain levels. The goal was to find a li…

This study looked at a new lab test called Antibiofilmogramme for people with diabetic foot infections caused by Staph bacteria. The goal was to see if the test could help doctors choose antibiotics that work better. 33 adults took part, and the study did not change their regular…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study looked at 60 intensive care patients with septic shock to see if their intestines become leaky, allowing bacteria to enter the blood. Researchers measured specific markers in the blood over a week to track gut damage and changes in gut bacteria. The goal was to better …

This study looked at 124 people with septic shock to see if the difference in carbon dioxide levels between veins and arteries could predict their recovery. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal was to fi…

This study tested whether bringing a portable TB test (Gene Xpert) directly to people in crowded communities helps find and treat more TB cases than the usual method of waiting for people to visit a clinic. Over 3,500 adults in South Africa took part. The goal was to see if this …

This study looked at how different meningococcal vaccines affect B cells, the white blood cells that produce antibodies. Researchers gave 20 healthy adults aged 30-70 either a polysaccharide or conjugate vaccine and then measured their B cell responses. The goal was to understand…

This study looked at whether using a portable ultrasound machine at the patient's bedside (called POCUS) helps doctors better treat people with septic shock in the intensive care unit. Researchers compared two groups of patients: one treated before POCUS was widely used and one a…

This study looked at health insurance records of over 81,000 people aged 14 to 44 in Germany to see how often chlamydia leads to serious health problems like infertility or pelvic disease, and how much it costs the healthcare system. Researchers tracked infections, complications,…

This completed study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked how often side effects occurred, how severe they were, and whether they affected quality of life. The goal was to understand why some patients st…

This completed study monitored over 14,000 hospital patients for multidrug-resistant organisms (MDROs) by taking rectal swabs and tracking bloodstream infections. Researchers analyzed the bacteria's genetics and how they resist antibiotics, aiming to understand how resistance eme…

This study looked at how much doxycycline builds up in body tissues after taking it daily for 7 days. Researchers measured levels in rectal and vaginal tissues to help design better ways to prevent bacterial sexually transmitted infections (STIs). 24 healthy adults took part, inc…

This study looked at 102 patients with bloodstream infections to compare standard lab cultures with two new rapid detection methods. The goal was to see how long germs stay in the blood and whether the new tests can give faster, more accurate results. This information could help …

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at whether giving antibiotics early to extremely low birthweight babies (born before 31 weeks) might cause more harm than good. Researchers compared babies who got standard antibiotics to those who got a placebo. The goal was to see if early antibiotics increase…

This study looked at whether eating fermented dairy products with three types of Bifidobacterium (with or without prebiotic fibers) for 28 days changes the variety of gut bacteria in healthy people aged 45 to 60. 182 participants ate either a test yogurt or a regular yogurt. The …

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study looked at whether information from national health insurance cards—like past antibiotic use and hospital stays—can predict if a person's urinary tract infection will be resistant to common antibiotics. Researchers analyzed data from over 1,100 patients with community-a…

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly as…

This study looked at 7,227 patients in Nanjing to understand how resistant the H. pylori bacteria is to common antibiotics. The goal was to find out which antibiotics still work best and to help doctors choose the right treatment for each patient. No new treatments were tested; i…

This study tested whether a rapid test called Unyvero could help doctors choose the right antibiotic sooner for patients with pneumonia who are on breathing machines in the ICU. The test looks for bacteria and their resistance genes in just a few hours, compared to standard lab c…

This study looked at whether having a dermatologist review a patient's skin condition remotely (teledermatology) could help emergency room doctors correctly identify true cellulitis (a bacterial skin infection) versus pseudocellulitis (a condition that looks like cellulitis but i…

This study surveyed 418 respiratory doctors in the Asia-Pacific region to understand how they diagnose tuberculous pleuritis, a type of TB that affects the lining around the lungs. The goal was to see which tests are used, how available they are, and how doctors decide to start t…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

Cellulitis is a painful skin infection that often requires antibiotics, but the ideal treatment length is unknown. This study followed 230 adults hospitalized with cellulitis to identify factors that predict a good recovery, such as medical history and early response to treatment…

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This study tested a simple way to get more HIV patients in South Africa the medicine that prevents tuberculosis (TB). Instead of doctors having to choose to prescribe it, the new approach made TB prevention the standard option, requiring doctors to actively opt out if they didn't…

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to …

This study examined whether giving ICU patients the same antibiotic they had before, versus a different one, affects the development of drug-resistant bacteria. Researchers looked at 197 adults with Gram-negative infections. The goal was to understand how antibiotic choice impact…

This completed study looked at 945 patients with septic shock to compare two ways of dosing vasopressors (medicines that raise blood pressure): one based on the patient's weight, and one not. The goal was to see which approach leads to better outcomes and fewer side effects, espe…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study looked at 42 adults with both H. pylori infection and small intestinal bacterial overgrowth (SIBO). Researchers used advanced DNA and chemical tests on stool samples to map the types of gut bacteria and their byproducts. The goal was to better understand how these two …

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study looked at two different ways of giving the antibiotic cloxacillin to treat bone and joint infections caused by Staphylococcus aureus bacteria. Twelve patients received the drug both as a steady drip (continuous infusion) and as short doses (intermittent infusion) to se…

This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek sw…

This study looked at 1,145 children under 18 who were hospitalized in France for mycoplasma infections between June and November 2023. Researchers collected medical data to better understand the infection and improve hospital care. The goal was to describe the infection's feature…

This study measured how common Mycoplasma genitalium (MG) infection is among HIV-positive men in Hong Kong and checked for antibiotic resistance. Researchers collected samples from 573 men attending an HIV clinic. The goal was to understand the spread of MG and whether common ant…

This study looked at 440 ICU patients with septic shock to see how their heart's pumping and relaxation abilities affected survival. Researchers measured heart function using ultrasound and tracked fluid balance. The goal was to better understand which heart problems are linked t…

This completed early-phase study tested a new way to study Strep A bacteria, which causes strep throat and can lead to serious heart disease. Researchers safely exposed 40 healthy adults aged 18-40 to a specific strain of Strep A under controlled conditions. The goal was to see h…

This study looked at 197 ICU patients with bloodstream infections caused by carbapenem-resistant bacteria (superbugs). Researchers used machine learning to analyze patient data and predict which patients were at higher risk of dying. The goal is to create a tool that helps doctor…

This study looked at how a short course of antibiotics changes the nerve and glia cells in the lower gut of 10 healthy adults. Researchers took colon tissue samples before and after antibiotic treatment to count these cells and measure gene activity. The goal was to understand if…

This study explored why some people with latent (inactive) tuberculosis (TB) are more likely to develop active TB. Researchers looked at 626 people in South India to see how malnutrition, diabetes, and worm infections might change the body's response to TB. Participants gave bloo…

This study looked at 100 adults with H. pylori infection to find out which antibiotics the bacteria are resistant to and which harmful genes they carry. Researchers took stomach biopsies during endoscopy to test the bacteria and also asked about diet and medication use. The goal …

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study aimed to create a smart surveillance strategy for carbapenem-resistant Pseudomonas aeruginosa (CRPA), a superbug that causes hard-to-treat infections in hospitals. Researchers collected samples from over 2,100 healthy people, patients, and hospital environments in the …

This study looked at 80 adults with septic shock to see if raising blood pressure from 65 mmHg to 85 mmHg improves kidney function. Researchers used ultrasound to measure kidney blood flow and tracked changes in kidney injury stages. The goal was to find out if a higher blood pre…

This study looked at whether measuring brain waves before a root canal can help predict how much pain a person will feel afterward. One hundred adults with tooth pain took part. Researchers recorded their brain activity at rest and then asked them to rate their pain after treatme…

This study created and tested a risk score called RESPIRE to predict whether a patient's pneumonia is caused by multidrug-resistant bacteria. Researchers looked at data from 300 adults with community-acquired pneumonia in the emergency department. The goal is to help doctors quic…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study looked at 232 adult cancer patients with sepsis and low blood pressure to see if adding a type of antibiotic called aminoglycosides helps them recover faster. The main goal was to see how quickly their blood pressure returned to normal without needing strong blood pres…

This study looked at whether measuring immature platelets in the blood can help predict how septic shock patients will fare. Researchers followed 196 intensive care patients and checked if the immature platelet fraction at admission was linked to death or organ failure at 28 days…

This study looked at whether antibiotics for H. pylori (a stomach infection) change the natural bacteria in the vagina. Researchers followed 73 women getting treatment and 10 healthy women. They collected vaginal samples before and after treatment to see if the bacteria mix shift…

This completed study looked at the safety of the VacPertagen whooping cough vaccine in over 5,400 people in Thailand, including pregnant women and their newborns. Healthcare workers reported any side effects after vaccination using standard forms. The goal was to catch any unexpe…

This study looked at whether giving a concentrated protein fluid called albumin, along with standard fluids, is possible in patients with septic shock (a life-threatening infection causing very low blood pressure). 47 adults took part to see if doctors could recruit enough patien…

This study looked at two blood markers—nCD64 and mHLA-DR—in 76 adults with septic shock, a life-threatening infection that can cause organ failure. Doctors measured these markers on day 1 and day 8 to see how the immune system changed over time. The goal was to learn whether thes…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study looked at 103 adults with septic shock to see if a protein called VEGF-A is linked to how much extra fluid their bodies hold. Septic shock causes blood vessels to leak, leading to dangerous fluid buildup. Researchers measured VEGF-A levels and fluid balance to better u…

This study observed how fluids are given to nearly 5,000 critically ill patients in intensive care units (ICUs) worldwide. The goal was to describe current practices for fluid challenges (boluses) and maintenance fluids, and to see if different approaches are linked to patient ou…

This completed study looked at 52 adults with septic shock to see if a protein called PTP1B and gut barrier changes are linked to muscle loss. Researchers took blood samples and used ultrasound to measure muscle. The goal was to gather knowledge, not to test a treatment.

This study examined over 1,200 adults admitted to an intensive care unit to see if the reason they were admitted (like sepsis or breathing failure) could predict their risk of dying in the ICU, beyond what standard severity scores show. Researchers looked back at medical records …

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This study looked back at medical records of 3000 people treated for H. pylori infection to see how often treatment actually works outside of controlled trials. Researchers collected data on which treatments were used and what factors, like antibiotic resistance or patient habits…

This completed study looked at whether a regional guideline for managing sepsis (a severe infection) in pregnant and postpartum women improved outcomes. Researchers compared 52 women treated before and after the guideline was introduced in Lombardy, Italy. They measured hospital …

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this g…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This completed study looked at how common gut inflammation and leaky gut are in 80 adults with blood cancer who were in intensive care for sepsis or septic shock. Researchers measured two markers—calprotectin in stool and zonulin in blood—to better understand intestinal dysfuncti…

This study looked at whether a score called EASIX, which uses routine blood test results, can predict death and poor outcomes in people with sepsis. Researchers followed 150 adults in the intensive care unit for 28 days. The goal was to see if this score could help doctors identi…

This study looked at health records from over 5,700 adults in Japan with sepsis (blood poisoning) to see how many also developed a serious blood clotting disorder called DIC. Researchers collected information from hospital databases to track DIC rates and severity scores. The goa…

This study looked at 688 adults hospitalized with pneumonia in 11 hospitals in Colombia to find out how many cases were caused by pneumococcal bacteria. Researchers also identified which bacterial strains were most common and whether current vaccines cover them. The goal is to he…

This study looked at whether having a dermatologist see patients within 24 hours of being admitted to the hospital for cellulitis (a skin infection) could improve their care. Researchers compared patients who got a dermatology consult to those who only saw their regular hospital …

This study tested whether giving a personalized dose of the antibiotic vancomycin to critically ill children in the ICU leads to better results than the standard approach. Researchers enrolled 314 children and compared how many reached the target drug level in their blood. The go…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This completed study looked at 200 women and their infants to understand how the whooping cough vaccine given during pregnancy affects the baby's immune protection. Researchers measured antibody levels in mothers and in umbilical cord blood at birth, as well as in infants after t…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study tested whether three new diagnostic tools could help doctors pick the best antibiotic faster for ICU patients with Gram-negative bloodstream infections. Researchers compared standard lab methods to the new tests in 100 patients. The goal was to see if more patients got…

This study aimed to create a way for doctors to predict which children with Mycoplasma pneumonia might become severely ill. Researchers looked at data from 964 children to build and test a prediction model. The goal is to help doctors act faster and improve outcomes for kids at r…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This early-stage study tested a single dose of the antibiotic TQD3524 in 48 people with varying degrees of kidney function. The goal was to see how the drug moves through the body and is removed, especially by the kidneys, and to check for any safety issues. The study did not aim…

This completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal …

This study tested whether the dose of norepinephrine, a drug used to raise blood pressure, changes how well a non-invasive finger sensor (peripheral perfusion index) can predict tissue health in 80 septic shock patients. Researchers compared two dose levels to see if the sensor's…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This study looked at how a new drug called linaprazan glurate interacts with common antibiotics (clarithromycin, amoxicillin) and bismuth in 56 adults. Some participants were healthy and H. pylori-negative, while others had H. pylori infection. The goal was to measure drug levels…

This study collected stool samples from 110 healthy adults aged 18-60 to help Danone advance its research on digestive health. Participants had to have regular bowel movements and be in good health. No treatment or medication was given; the goal was simply to gather enough usable…

This study looked at whether exposure to PFAS chemicals (found in some water supplies) can weaken the body's immune response to the tetanus and diphtheria booster vaccine. Twenty adults from a community with known PFAS exposure received the vaccine and had blood and saliva sample…

This completed study looked at 30 patients with septic shock in the ICU. Researchers wanted to see how high doses of the drug norepinephrine affect not just large blood vessels, but also tiny ones (microcirculation). They used a non-invasive light-based device to measure oxygen l…

This study looked at 300 people to see if a common stomach infection, H. pylori, is linked to unhealthy blood fat levels that can lead to heart disease. Researchers measured triglycerides and 'good' cholesterol to calculate a heart risk score. The goal is to understand if treatin…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study looked at how staphylococcus bacteria on the skin affect inflammation and immune responses in people with moderate to severe atopic dermatitis (eczema). Researchers took skin biopsies and blood samples from 41 adults to measure bacterial toxins and immune cell activity…