Could a simple stool test revolutionize TB diagnosis for kids and HIV patients?
NCT ID NCT05047315
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to standard methods like sputum tests. The goal is to make TB diagnosis easier and more accessible for those who are often missed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
stool-based qPCR diagnostic test
What this could lead to
If successful, this could provide a simpler, non-invasive way to diagnose tuberculosis in hard-to-test groups like children and people with HIV, potentially increasing detection rates.
What could go wrong
This is a completed diagnostic accuracy study, not a treatment trial. The test may not be accurate enough in real-world settings, and it does not directly improve health outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor Eswatini Clinical Centre of Excellence (COE)
Mbabane, Eswatini
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Centro de investigação de Saúde de Manhiça
Manhiça, Maputo Province, 1929, Mozambique
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Makerere University
Kampala, Uganda