Could a simple stool test revolutionize TB diagnosis for kids and HIV patients?

NCT ID NCT05047315

Completed Diagnosis Sponsor: Barcelona Institute for Global Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to standard methods like sputum tests. The goal is to make TB diagnosis easier and more accessible for those who are often missed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stool-based qPCR diagnostic test
What this could lead to: If successful, this could provide a simpler, non-invasive way to diagnose tuberculosis in hard-to-test groups like children and people with HIV, potentially increasing detection rates.
What could go wrong: This is a completed diagnostic accuracy study, not a treatment trial. The test may not be accurate enough in real-world settings, and it does not directly improve health outcomes.

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Conditions

The condition(s) this trial relates to.

disease pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIAGNOSES DISEASE TUBERCULOSIS

Contacts and locations

Locations

Baylor Eswatini Clinical Centre of Excellence (COE)

Mbabane, Eswatini
Centro de investigação de Saúde de Manhiça

Manhiça, Maputo Province, 1929, Mozambique
Makerere University

Kampala, Uganda

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