Hotspot vs clinic: which TB hunt saves more lives?

NCT ID NCT05285202

Completed Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will track how many people are diagnosed with TB and started on preventive therapy under each approach, involving up to 150,000 participants over five years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that focusing TB screening on local hotspots finds more undiagnosed cases and gets more people onto preventive treatment than clinic-based screening alone.
What could go wrong: This is a large implementation study, not a drug trial, so it won't produce a new treatment. Results may depend on local conditions in Uganda and might not apply elsewhere.

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Conditions

The condition(s) this trial relates to.

latent tuberculosis infection pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYCOBACTERIUM TUBERCULOSIS INFECTION TUBERCULOSIS, PULMONARY

Contacts and locations

Locations

Walimu

Kampala, Uganda

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