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ICU ulcer prevention drug under scrutiny: does pantoprazole help or harm?

NCT ID NCT02467621

Completed Disease control Sponsor: Dr. Morten Hylander Møller Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked deaths, bleeding, pneumonia, and other complications to weigh benefits and risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Pantoprazole (a proton pump inhibitor, given intravenously)
What this could lead to
If successful, this could confirm that pantoprazole safely prevents stress ulcers in ICU patients without increasing serious side effects.
What could go wrong
This is a completed Phase 4 trial, but the results may not apply to all ICU patients. Potential harms like pneumonia or infection were also tracked.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Clostridium infectious disease Gastrointestinal Hemorrhage pneumonia duodenal ulcer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL BLEEDING STRESS ULCERS

Contacts and locations

Locations

  • Dept. of Intensive Care 4131, Copenhagen University Hospital Rigshospitalet

    Copenhagen, 2100, Denmark

  • Dept. of Intensive Care, Aalborg University Hospital

    Aalborg, 9000, Denmark

  • Dept. of Intensive Care, Akershus University Hospital

    Lørenskog, 1478, Norway

  • Dept. of Intensive Care, Basel University Hospital

    Basel, 4056, Switzerland

  • Dept. of Intensive Care, Bergen University Hospital

    Bergen, 5021, Norway

  • Dept. of Intensive Care, Bern University Hospital

    Bern, 3010, Switzerland

  • Dept. of Intensive Care, Bispebjerg Hospital

    Copenhagen, 2400, Denmark

  • Dept. of Intensive Care, Copenhagen University Hospital Herlev

    Herlev, 2730, Denmark

  • Dept. of Intensive Care, Heerlen Hospital

    Heerlen, 6419, Netherlands

  • Dept. of Intensive Care, Helsinki University Hospital

    Helsinki, 00120, Finland

  • Dept. of Intensive Care, Herning Hospital

    Herning, 7400, Denmark

  • Dept. of Intensive Care, Hillerød Hospital

    Hillerød, 3400, Denmark

  • Dept. of Intensive Care, Hjørring Hospital

    Hjørring, 9800, Denmark

  • Dept. of Intensive Care, Holbæk Hospital

    Holbæk, 4300, Denmark

  • Dept. of Intensive Care, Holstebro Hospital

    Holstebro, 7500, Denmark

  • Dept. of Intensive Care, Kuopio University Hospital

    Kuopio, 70029, Finland

  • Dept. of Intensive Care, Køge University Hospital

    Køge, 4600, Denmark

  • Dept. of Intensive Care, Nykøbing Falster Sygehus

    Nykøbing Falster, 4800, Denmark

  • Dept. of Intensive Care, Oslo University Hospital

    Oslo, 0450, Norway

  • Dept. of Intensive Care, Oulu University Hospital

    Oulu, 90210, Finland

  • Dept. of Intensive Care, Randers Hospital

    Randers, 8930, Denmark

  • Dept. of Intensive Care, Roskilde Hospital

    Roskilde, 4000, Denmark

  • Dept. of Intensive Care, Slagelse Hospital

    Slagelse, 4200, Denmark

  • Dept. of Intensive Care, Stavanger University Hospital

    Stavanger, 4011, Norway

  • Dept. of Intensive Care, Tampere University Hospital

    Tampere, 33520, Finland

  • Dept. of Intensive Care, Turku University Hospital

    Turku, 20521, Finland

  • Dept. of Intensive Care, University Hospital of Wales

    Cardiff, United Kingdom

  • Dept. of Intensive Care, University Medical Center Groningen

    Groningen, 9713, Netherlands

  • Dept. of Intensive Care, Vejle Hospital

    Vejle, 7100, Denmark

  • Dept. of Intensive Care, Viborg Hospital

    Viborg, 8800, Denmark

  • Dept. of Intensive Care, Århus University Hospital Nørrebrogade

    Aarhus, 8000, Denmark

  • Dept. of Intensive Care, Århus University Hospital Skejby

    Aarhus, 8000, Denmark

  • Dept. of Neurointensive Care, Copenhagen University Hospital Rigshospitalet

    Copenhagen, 2100, Denmark

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