Could a simple pill replace IV drips for blood infections?
NCT ID NCT05199324
First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times
Summary
This study tests whether stable patients with a common blood infection (gram-negative bacteraemia) can safely switch from IV antibiotics to oral pills within 72 hours. Researchers will compare early oral therapy to continued IV treatment in 720 adults. The main goal is to see if survival rates at 30 days are similar between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Oral fluoroquinolones (e.g., ciprofloxacin) or oral trimethoprim-sulfamethoxazole (Bactrim)
- What this could lead to
- If successful, this could show that switching to oral antibiotics early is as safe and effective as staying on IV therapy, potentially reducing hospital stays and treatment costs.
- What could go wrong
- This is a single-center trial, and results may not apply to all patients. The oral antibiotics may not work as well in sicker patients or those with hidden infection sources.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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American University of Beirut Medical Center
Beirut, 1107 2020, Lebanon
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Changi General Hospital
Singapore, Singapore, 529889, Singapore
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Gold Coast University Hospital
Southport, Queensland, 4215, Australia
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Hospital Ampang
Ampang, 68000, Malaysia
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Hospital Universiti Kebangsaan Malaysia
Kuala Lumpur, 56000, Malaysia
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Hospital del Mar
Barcelona, 08003, Spain
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IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola
Bologna, 40138, Italy
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IRCCS Hospital San Raffaele
Milan, 20132, Italy
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Medipol Mega University Hospital
Istanbul, 34214, Turkey (Türkiye)
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National University Hospital
Singapore, Singapore, 119074, Singapore
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Ng Teng Fong General Hospital
Singapore, Singapore, 609606, Singapore
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Rambam Hospital
Haifa, 3109601, Israel
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Royal Melbourne Hospital
Melbourne, Victoria, 3050, Australia
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Samsung Medical Center
Soeul, 06351, South Korea
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Sengkang General Hospital
Singapore, Singapore, 544886, Singapore
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Seoul National University Bandang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Sheba Medical Center
Ramat Gan, 5262000, Israel
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Singapore General Hospital
Singapore, Singapore, 169608, Singapore
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Sungai Buloh Hospital
Sungai Buloh, 47000, Malaysia
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Taichung Veterans General Hospital
Taichung, Xitun District, 407219, Taiwan
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Tan Tock Seng Hospital
Singapore, Singapore, 308433, Singapore
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Universiti Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
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University General Hospital of Patras
Pátrai, 26504, Greece
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University Hospital of Pisa
Pisa, 56124, Italy