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Which antibiotic works best to prevent early labor in High-Risk pregnancies?

NCT ID NCT01722708

Disease control Sponsor: HaEmek Medical Center, Israel Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two common antibiotics, clindamycin and metronidazole, taken orally for a week to treat abnormal vaginal flora in pregnant women at high risk for preterm labor. The goal was to see which drug better clears the infection and reduces risks like early delivery. 166 women participated, and researchers tracked side effects and pregnancy outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Clindamycin and metronidazole (oral antibiotics)
What this could lead to
If one antibiotic works better, it could help prevent preterm labor in high-risk pregnancies by clearing abnormal vaginal flora.
What could go wrong
This is a small, completed trial with 166 participants, so results may not apply to all pregnant women. Both drugs can cause side effects like stomach upset or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

166 people

The number who actually took part.

Started

Nov 2012

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women at increased risk for preterm labor (preterm cervical effacement, preterm uterine contractions, twins pregnancy, vaginal bleeding, past preterm delivery) * Age above 18 years Exclusion Criteria: * Known allergy to the tested antibiotics * Antibacterial treatment in the week before the vaginal culture was taken * preterm premature rupture of membranes

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Conditions

The condition(s) this trial relates to.

bacterial vaginosis Obstetric Labor, Premature

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abnormal vaginal flora Clindamycin VS metronidazole High risk pregnancies for preterm labor

Contacts and locations

Locations

  • Departement of obstetric and gynecology, HaEmek medical center

    Afula, Israel

  • Departement of obstetric and gynecology, Poriya Medical Center

    Tiberias, Israel, Israel