TB cases sought in COVID-19 trial volunteers

NCT ID NCT06585683

Completed Knowledge-focused Sponsor: COVID-19 Prevention Network Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this group and improve future detection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify TB cases and biomarkers, pointing toward better TB detection methods.
What could go wrong: This is an observational substudy with no new treatment, so it won't directly improve health. Results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS

Contacts and locations

Locations

Aurum Institute Klerksdorp CRS

Klerksdorp, North West, South Africa
Baylor-Uganda CRS

Kampala, Uganda
Blantyre CRS

Blantyre, Malawi
CAPRISA eThekwini CRS

Durban, KwaZulu-Natal, South Africa
Cfhrz Crs

Lusaka, Zambia
Clinical HIV Research Unit (CHRU)/ Helen Joseph CRS

Johannesburg, Gauteng, South Africa
Emavundleni CRS

Cape Town, Western Cape, South Africa
Eswatini Prevention Center CRS

Mbabane, Eswatini
FAM-CRU (Family Clinical Research Unit)

Cape Town, Western Cape, South Africa
Gaborone CRS

Gaborone, Botswana
Groote Schuur HIV CRS

Cape Town, Western Cape, South Africa
Isipingo CRS

Isipingo, KwaZulu-Natal, South Africa
Joint Clinical Research Centre

Kampala, Uganda
Josha Resarch CRS

Bloemfontein, Free State, South Africa
Kisumu Crs

Kisumu, Kenya
Kliptown Soweto CRS

Johannesburg, South Africa
Kombewa Clinical Research Center

Kisumu, Kenya
MU-JHU Research Collaboration CRS

Kampala, Uganda
Malawi CRS

Lilongwe, Malawi
Masiphumelele Clinical Research Site (MASI) CRS

Cape Town, Western Cape, South Africa
Matero Reference Clinic CRS

Lusaka, Zambia
MeCRU CRS

Ga-Rankuwa, Gauteng, South Africa
Moi University Clinical Research Centre

Eldoret, Kenya
Nelson Mandela Academic Research Unit CRS

Mthatha, Eastern Cape, South Africa
Newtown Clinical Research

Johannesburg, Gauteng, South Africa
PHOENIX Pharma (Pty) Ltd

Port Elizabeth, Eastern Cape, South Africa
PHRU Matlosana CRS

Klerksdorp, South Africa
Qhakaza Mbokodo Research Clinic CRS

Ladysmith, KwaZulu-Natal, South Africa
Rustenburg CRS

Rustenburg, North West, South Africa
Soweto - Bara CRS

Johannesburg, Gauteng, South Africa
Synergy Biomed Research Institute

East London, Eastern Cape, South Africa
TASK Central

Cape Town, Western Cape, South Africa
TASK Eden

George, Western Cape, South Africa
Tembisa Clinic 4 CoVPN CRS

Tembisa, Gauteng, South Africa
Tongaat CRS

Durban, KwaZulu-Natal, South Africa
UNC Global Projects / Kamwala District Health Centre

Lusaka, Zambia
UVRI-IAVI HIV Vaccine Program LTD. CRS

Entebbe, Uganda
Univeristy of Cape Town Lung CRS Institute

Cape Town, Western Cape, South Africa
Vulindlela CRS

Durban, KwaZulu-Natal, South Africa
Wits RHI Ward 21 CRS

Johannesburg, Gauteng, South Africa
Zambia Emory HIV Research Project - Ndola CoVPN CRS

Ndola, Zambia

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