Could fewer antibiotics be better for MAC lung disease?
NCT ID NCT03672630
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether taking two antibiotics instead of three is just as effective for treating a lung infection called MAC, while causing fewer side effects. 474 adults with MAC lung disease were randomly assigned to receive either two or three drugs for 12 months. The goal was to see if the two-drug regimen could clear the infection and be easier to tolerate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Azithromycin, Ethambutol, Rifampin
- What this could lead to
- If successful, this could show that a two-drug regimen works as well as three drugs, with fewer side effects for patients with MAC lung disease.
- What could go wrong
- This is a completed Phase 2/3 trial, but results may not apply to all patients, and reducing drugs could lower effectiveness in some cases.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Columbia University Medical Center
New York, New York, 10032, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Johns Hopkins University
Baltimore, Maryland, 21224, United States
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Kaiser Permanente Hawaii
Honolulu, Hawaii, 96817, United States
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Loma Linda University Medical Center
Loma Linda, California, 92354, United States
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Louisina State University
New Orleans, Louisiana, 70112, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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National Jewish Health
Denver, Colorado, 80206, United States
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New York University
New York, New York, 10016, United States
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Northwell Health
Manhasset, New York, 11030, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Stanford University
Stanford, California, 94305, United States
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Tampa VA Medical Center
Tampa, Florida, 33612, United States
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Temple University
Philadelphia, Pennsylvania, 19140, United States
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University Health Network
Toronto, Ontario, M5T2S8, Canada
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University of California, San Diego
San Diego, California, 92103, United States
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University of California, San Francisco
San Francisco, California, 94110, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Kansas
Kansas City, Kansas, 66160, United States
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University of Miami
Miami, Florida, 33136, United States
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University of North Carolina
Chapel Hill, North Carolina, 27599, United States
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University of Texas Health Science Center
Tyler, Texas, 75708, United States
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University of Washington
Seattle, Washington, 98104, United States
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University of Wisconsin School of Medicine and Public Health
Madison, Wisconsin, 53705, United States
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Vancouver Clinic
Vancouver, Washington, 98664, United States
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