Could fewer antibiotics be better for MAC lung disease?

NCT ID NCT03672630

First seen Feb 02, 2026 · Last updated May 17, 2026 · Updated 16 times

Summary

This study tested whether taking two antibiotics instead of the usual three is just as effective for treating a lung infection called MAC, while causing fewer side effects. About 474 adults with MAC lung disease were assigned to either a two-drug or three-drug regimen for 12 months. The goal was to see if the simpler treatment could clear the infection and be easier to tolerate.

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Contacts and locations

Locations

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21224, United States

  • Kaiser Permanente Hawaii

    Honolulu, Hawaii, 96817, United States

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • Louisina State University

    New Orleans, Louisiana, 70112, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • New York University

    New York, New York, 10016, United States

  • Northwell Health

    Manhasset, New York, 11030, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Stanford University

    Stanford, California, 94305, United States

  • Tampa VA Medical Center

    Tampa, Florida, 33612, United States

  • Temple University

    Philadelphia, Pennsylvania, 19140, United States

  • University Health Network

    Toronto, Ontario, M5T2S8, Canada

  • University of California, San Diego

    San Diego, California, 92103, United States

  • University of California, San Francisco

    San Francisco, California, 94110, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Kansas

    Kansas City, Kansas, 66160, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of North Carolina

    Chapel Hill, North Carolina, 27599, United States

  • University of Texas Health Science Center

    Tyler, Texas, 75708, United States

  • University of Washington

    Seattle, Washington, 98104, United States

  • University of Wisconsin School of Medicine and Public Health

    Madison, Wisconsin, 53705, United States

  • Vancouver Clinic

    Vancouver, Washington, 98664, United States

Conditions

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