New vaccine aims to protect infants from deadly diarrhea
NCT ID NCT04056117
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Different doses are being tested to find the best one for infants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Shigella4V vaccine
What this could lead to
If successful, this vaccine could protect infants and children from severe diarrheal disease caused by Shigella bacteria, reducing illness and death in regions where it is common.
What could go wrong
This is an early-phase trial, so the vaccine may not prove effective or may cause side effects. Results in adults may not predict how well it works in infants.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
Contacts and locations
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Locations
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KEMRI-Centre Geographic Medical Research-COAST (KEMRI-CGMRC)
Kilifi, 230-80108, Kenya
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Kenya Medical Research Institute (KEMRI)/ United States Army Medical Research Directorate- Kenya (USAMRD-K)
Kericho, 1357-20200, Kenya