Could a common diabetes drug help fight TB in HIV patients?
NCT ID NCT04930744
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored side effects, drug levels, and lung function to see if the combination works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin
What this could lead to
If it works, this could point toward a safer, faster TB treatment for people with HIV, reducing lung damage.
What could go wrong
This is a small Phase 2 trial, so results may not apply to everyone. Adding metformin could cause side effects or not improve outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Isango Lethemba TB Research Unit
Port Elizabeth, South Africa
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Tembisa Clinical Research Centre-The Aurum Institute
Johannesburg, Gauteng, 1632, South Africa