New vaccine trial aims to shield toddlers from pneumococcal disease

NCT ID NCT06531538

Completed ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new pneumococcal vaccine in 225 healthy toddlers aged 12 to 15 months. The goal was to check safety and how well the vaccine triggers an immune response. Participants received either one or two doses and were monitored for side effects and antibody levels over several months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: multivalent pneumococcal conjugate vaccine
What this could lead to: If successful, this could lead to a vaccine that better protects toddlers against pneumococcal disease, reducing infections like pneumonia and meningitis.
What could go wrong: This is an early Phase 2 trial with only 225 participants, so results may not confirm broad effectiveness or safety. Side effects like injection site pain or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pneumococcal infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMOCOCCAL DISEASE

Contacts and locations

Locations

Atrium Health - Strive Vaccine Research Clinic

Charlotte, North Carolina, 28207, United States
Atrium Health-Matthews

Matthews, North Carolina, 28105, United States
Atrium Health-Myers Park

Charlotte, North Carolina, 28207, United States
BRCR Global Puerto Rico

San Juan, 00907-1509, Puerto Rico
BRCR Medical Center - Ponce

Ponce, 00717, Puerto Rico
Bio-Medical Research LLC

Miami, Florida, 33144, United States
CMRC Headlands, LLC

San Juan, 00918, Puerto Rico
Carolina Family Care

Charleston, South Carolina, 29414, United States
Carolina Family Care

Summerville, South Carolina, 29486, United States
DM Clinical Research - Kool Kids Pediatrics

Houston, Texas, 77065, United States
Duke University

Durham, North Carolina, 27705, United States
Duke Vaccine and Trials Unit

Durham, North Carolina, 27703, United States
Durham Pediatrics at North Duke Street

Durham, North Carolina, 27704, United States
Emerson Clinical Research Institute

Washington D.C., District of Columbia, 20009, United States
Holston Medical Group

Kingsport, Tennessee, 37660, United States
Javara - Privia Medical Group Georgia - Fayetteville

Fayetteville, Georgia, 30214, United States
Javara - Privia Medical Group North Texas - Dallas

Dallas, Texas, 75230, United States
Kool Kids Pediatrics

Houston, Texas, 77065, United States
Louisiana State University Health Sciences Shreveport

Shreveport, Louisiana, 71103, United States
Louisiana State University Health Sciences Shreveport - Fairfield avenue

Shreveport, Louisiana, 71101, United States
MUSC Children's Health

Charleston, South Carolina, 29414, United States
MUSC Children's Health

Summerville, South Carolina, 29486, United States
Mercury Clinical Research - Houston

Houston, Texas, 77054, United States
Mercury Clinical Research - North Houston Internal Medicine & Pediatric Clinic

Tomball, Texas, 77375, United States
Mercury Clinical Research - Pediatric Associates

Houston, Texas, 77087, United States
Mercury Clinical Research - Sunrise Pediatrics

Houston, Texas, 77077, United States
Oak Cliff Research Company, LLC

Dallas, Texas, 75252, United States
Oak Cliff Research Company, LLC

Dallas, Texas, 75287, United States
Ochsner/LSU Health Ambulatory Care Center

Shreveport, Louisiana, 71103, United States
Pediatric Clinical Trials of Tennessee, LLC

Tullahoma, Tennessee, 37388, United States
Ponce Medical School Foundation Inc.

Ponce, 00716, Puerto Rico
Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, 30291, United States
Senders Pediatrics

South Euclid, Ohio, 44121, United States
Tekton Research, LLC.

Chamblee, Georgia, 30341, United States
The Iowa Clinic

Ankeny, Iowa, 50023, United States
The Pediatric Center

Columbia, Maryland, 21045, United States
University of Maryland, Baltimore - Institutional Review Board

Baltimore, Maryland, 21201, United States
University of Maryland, Baltimore, Center for Vaccine Development and Global Health

Baltimore, Maryland, 21201, United States
University of Texas Medical Branch

League City, Texas, 77573, United States

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