Bacterial infectious disease

This early-stage study tested a new meningococcal B vaccine in 576 healthy people, from infants to adults. Researchers checked for side effects and measured immune responses, comparing the new vaccine to two already-approved ones. The goal was to see if the vaccine is safe and tr…

This study tested whether an extra dose of bezlotoxumab, a drug that blocks the harmful toxin made by C. diff bacteria, could help very sick patients recover after emergency colon surgery. Only 5 people took part before the study was stopped early. The goal was to see if the drug…

This study tested an oral drug called epetraborole for people with a tough-to-treat lung infection called MAC lung disease. The trial aimed to see if adding epetraborole to standard treatment could improve symptoms and clear the infection. However, the study was terminated early,…

This study tested whether adding aspirin or ibuprofen to standard tuberculosis (TB) treatment helps patients recover more quickly. It included 426 adults with drug-sensitive or drug-resistant TB. The trial was terminated early, so the results are not conclusive.

This clinical trial tested whether combining several drugs—bedaquiline, OPC-167832, sutezolid, and either pretomanid or delamanid—could treat pulmonary tuberculosis in just 2 to 4 months instead of the standard 6 months. The study enrolled 93 adults with drug-sensitive or drug-re…

This study looked at the best way to treat a tonsillar abscess, a painful infection near the tonsils. It compared two treatments: removing the tonsils (tonsillectomy) versus draining the pus with a needle under local anesthesia. The goal was to see which method works better to cl…

This study tested whether a simple stool test can guide doctors in choosing the right antibiotics for H. pylori infections, avoiding the need for an invasive stomach camera procedure. The test detects the bacteria and checks for antibiotic resistance, aiming to improve cure rates…

This study looked at whether starting continuous skin-to-skin contact (kangaroo mother care) within 24 hours of birth helps unstable preterm babies under 2000g survive. It compared this to standard incubator care. The trial took place in The Gambia and enrolled 279 babies, but wa…

This study tested whether using a urine biomarker test (NephroCheck) to guide treatment could reduce kidney injury, dialysis, or death in sepsis patients. The trial planned to enroll many participants but was stopped early after only 19 people joined. The idea was to catch kidney…

This study looked at two different antibiotic combinations for treating early syphilis in people living with HIV. One group received a single shot of ceftriaxone plus a week of doxycycline pills, while the other got the standard single shot of penicillin plus the same doxycycline…

This study looked at 500 adults with septic shock and severe acute kidney injury to see if starting dialysis early (within 12 hours) or waiting (48-60 hours) affected survival at 90 days. The trial was terminated early, so the results are not conclusive. The goal was to find the …

This study tested whether a sedative drug called dexmedetomidine could help restore blood pressure control in patients with severe septic shock that does not respond to standard treatments. The trial involved 32 adults in intensive care. The goal was to see if the drug could impr…

This study tested whether the antibiotic ceftolozane-tazobactam, guided by a rapid molecular test, could effectively treat serious Pseudomonas aeruginosa infections in people with blood cancers or those who had a stem cell transplant. The 17 participants received the antibiotic t…

This study tested whether intense pulsed light (IPL) can help treat chalazion, a common eyelid lump. Only 4 adults with a fresh chalazion were enrolled, and the trial was stopped early. Because of the very small size, we cannot say if IPL works or is safe for this condition.

This study tested a complete kit using povidone-iodine (Betadine) gel, soap, and mouthwash to clear MRSA bacteria from patients' noses, skin, and mouths. The goal was to see if the kit could quickly decolonize MRSA within 6 hours. However, the trial was terminated early after enr…

This study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than…

This study tested whether a rapid lab test (looking for integrons in urine) could help doctors choose a narrow-spectrum antibiotic instead of a broad-spectrum one for children with fever and a urinary tract infection. The goal was to see if this approach works as well as standard…

This study tested a new drug called REC-3964 to see if it could prevent repeat Clostridioides difficile (C. diff) infections in adults. Only 3 people were enrolled before the trial was stopped early. The goal was to check safety and whether the drug helped people stay infection-f…

This phase 3 study tested an inhaled form of the antibiotic clofazimine added to standard therapy for people with MAC lung disease that did not respond to previous treatment. The goal was to see if the drug could clear the infection from sputum cultures and improve quality of lif…

This study tested whether the oral drug midodrine could help people with septic shock stop needing IV blood pressure support sooner. The trial planned to enroll many patients but was stopped early with only 10 participants. Because it was so small, we cannot draw firm conclusions…

This study tested the antibiotic teicoplanin (taken by mouth twice daily for 7 to 14 days) in 50 adults hospitalized with C. difficile infection causing diarrhea and colitis. The goal was to see if it could stop diarrhea and prevent it from coming back. The trial was terminated e…

This study tested a special multi-line device (Edelvaiss Multiline NEO) to see if it could prevent bloodstream infections in very premature infants (24-29 weeks) who need IV medications and nutrition. The device was compared to standard infusion sets. Unfortunately, the trial was…

This study aimed to see if a single dose of the BCG vaccine could prevent tuberculosis infection in healthy adults traveling to countries with high TB rates. Participants were randomly assigned to receive either BCG or a placebo. The study was terminated early and enrolled only 1…

This study looked at whether a special protocol used by community pharmacists in France can help women with simple bladder infections (cystitis) get relief more quickly. The goal was to reduce symptoms and avoid unnecessary trips to the doctor or emergency room. The study include…

This study tested whether a gas sedative (isoflurane) could help patients with septic shock wake up and get off a breathing machine faster than standard IV sedation (midazolam). The goal was to reduce complications from long-term sedation and ventilation. Only one patient was enr…

This study tested whether adding physical rehabilitation and personalized nutrition to standard care helps patients with infective endocarditis (a serious heart infection) feel better during their hospital stay. The goal was to improve mental health and quality of life. The study…

This study aimed to see if taking NSAIDs (like naproxen) on a regular schedule could reduce arthritis symptoms and prevent long-term joint problems in people with Lyme disease. Only 3 participants were enrolled before the study was stopped, so no clear conclusions can be drawn. T…

This study looked at whether a weak immune response to bacteria in COPD patients leads to more lung infections and flare-ups. Researchers collected sputum, blood, and nasal swabs from 23 hospitalized COPD patients during a flare-up and again 8 to 16 weeks later. The goal was to m…

This study looked at whether a newer, low-dose X-ray system (EOSedge) produces images good enough for planning hip replacement or revision surgery, compared to standard digital X-rays. About 97 adults who needed hip surgery X-rays took part. The goal was to see if using just one …

This study looked for new markers in blood and joint fluid to help doctors tell the difference between septic arthritis (a joint infection) and juvenile idiopathic arthritis (an inflammatory condition) in children. Researchers planned to analyze samples from 100 children under 15…

This study tested whether raising the blood pressure target from 65 mmHg to 85 mmHg in patients with septic shock could help prevent kidney injury. Researchers used a drug called norepinephrine to adjust blood pressure and monitored kidney function. The trial was stopped early an…

This study looked at whether certain genetic differences in the immune system make some people more likely to develop severe bloodstream infections from E. coli or Staphylococcus aureus bacteria. Researchers planned to analyze blood samples from 60 patients to find mutations link…

This study followed women who previously received 1 to 3 doses of an experimental Group B Strep (GBS) vaccine. The goal was to see how long their immune antibodies lasted by taking yearly blood samples for 2 to 5 years. No new vaccine or treatment was given—only observation.

This observational study aimed to understand why some septic shock patients respond better to the drug vasopressin. Researchers planned to compare blood markers, heart ultrasound images, and tissue oxygen levels between responders and non-responders. However, the study was termin…

This study gave healthy adults nose drops containing a harmless bacteria (N. lactamica) to see how the body's immune system responds. The goal is to learn if the immune response is the same whether the bacteria is cleared after 4 days or 14 days. This information will help design…

This study tested whether placing a reminder sticker on the charts of adult hospital patients receiving IV fluoroquinolone antibiotics would encourage doctors to switch them to oral pills sooner. The trial involved 168 patients at a single hospital in Thailand. Unfortunately, the…

This study followed 190 young women to learn how the body handles new HPV infections. Researchers measured virus levels, immune cells, and other factors over time. The goal was to understand why some infections clear quickly while others persist. No treatment was given; this was …