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Gene hunt: why some people get worse blood infections

NCT ID NCT03869593

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether certain genetic differences in the immune system make some people more likely to develop severe bloodstream infections from E. coli or Staphylococcus aureus bacteria. Researchers planned to analyze blood samples from 60 patients to find mutations linked to sepsis. The study was terminated early, so results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Jun 2019

Finished

Sep 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient with S. aureus or E. coli bacteremia defined by at least one positive blood culture

Ages

8 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with S. aureus or E. coli bacteriostatic bacteremia defined by at least one positive blood culture bottle * Patient requiring a blood test as part of his bacteremia * not subject to a judicial protection measure * Signature of the non-opposition of consent (for minor patients signed by one of the parents or the representative of the parental authority) * Affiliation to social security Exclusion Criteria: * Immunocompromised patient defined by: * current immunosuppressive therapies: corticosteroids, chemotherapy, biotherapy * solid organ transplant patient or hematopoietic stem cell transplant * chemotherapy-induced neutropenia * Congenital immune deficiency * bacteremia related to a peripheral or central catheter * Urinary obstruction not lifted within the first 24 hours of management * Intra-abdominal infection collected undrained in the first 24 hours of management * primary infectious focus represented by mechanically ventilated pneumonia * Pregnant or lactating woman

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Conditions

The condition(s) this trial relates to.

escherichia coli infection staphylococcal infection staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Escherichia coli infections Staphylococcus aureus

Contacts and locations

Locations

  • CH Pierre Nouveau

    Cannes, France

  • CHG d'Antibes

    Antibes, France

  • CHU de Lenval

    Nice, France

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