New hope for recurring c. diff: which treatment works best?

NCT ID NCT02667418

Terminated Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than standard vancomycin treatment. The trial was stopped early, but it aimed to find the best way to keep symptoms from returning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fidaxomicin and vancomycin
What this could lead to: If successful, this could identify a more effective treatment regimen for recurrent C. diff infection, reducing relapse rates.
What could go wrong: The trial was terminated early, so results may be incomplete. It's a phase 4 study, but limited data may reduce confidence in findings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLOSTRIDIUM DIFFICILE FIDAXOMICIN VANCOMYCIN

Contacts and locations

Locations

Asheville VA Medical Center, Asheville, NC

Asheville, North Carolina, 28805-2576, United States
Atlanta VA Medical and Rehab Center, Decatur, GA

Decatur, Georgia, 30033-4004, United States
Bay Pines VA Healthcare System, Pay Pines, FL

Bay Pines, Florida, 33744-0000, United States
Central Arkansas Veterans Healthcare System, Little Rock, AR

Little Rock, Arkansas, 72205, United States
Clement J. Zablocki VA Medical Center, Milwaukee, WI

Milwaukee, Wisconsin, 53295-0001, United States
Durham VA Medical Center, Durham, NC

Durham, North Carolina, 27705-3875, United States
Edward Hines Jr. VA Hospital, Hines, IL

Hines, Illinois, 60141-3030, United States
Edward Hines Jr. VA Hospital, Hines, IL

Hines, Illinois, 60141, United States
James A. Haley Veterans' Hospital, Tampa, FL

Tampa, Florida, 33612, United States
Jesse Brown VA Medical Center, Chicago, IL

Chicago, Illinois, 60612, United States
John D. Dingell VA Medical Center, Detroit, MI

Detroit, Michigan, 48201-1916, United States
Louis Stokes VA Medical Center, Cleveland, OH

Cleveland, Ohio, 44106-1702, United States
Michael E. DeBakey VA Medical Center, Houston, TX

Houston, Texas, 77030, United States
North Florida/South Georgia Veterans Health System, Gainesville, FL

Gainesville, Florida, 32608-1135, United States
Oklahoma City VA Medical Center, Oklahoma City, OK

Oklahoma City, Oklahoma, 73104-5007, United States
Phoenix VA Health Care System, Phoenix, AZ

Phoenix, Arizona, 85012, United States
Rehabilitation R&D Service, Baltimore, MD

Baltimore, Maryland, 21202, United States
Rocky Mountain Regional VA Medical Center, Aurora, CO

Aurora, Colorado, 80045-7211, United States
South Texas Health Care System, San Antonio, TX

San Antonio, Texas, 78229, United States
Southern Arizona VA Health Care System, Tucson, AZ

Tucson, Arizona, 85723-0001, United States
VA Ann Arbor Healthcare System, Ann Arbor, MI

Ann Arbor, Michigan, 48105, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Boston, Massachusetts, 02130-4817, United States
VA Caribbean Healthcare System, San Juan, PR

San Juan, 00921, Puerto Rico
VA Greater Los Angeles Healthcare System, West Los Angeles, CA

West Los Angeles, California, 90073, United States
VA Loma Linda Healthcare System, Loma Linda, CA

Loma Linda, California, 92357, United States
VA Long Beach Healthcare System, Long Beach, CA

Long Beach, California, 90822, United States
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX

Dallas, Texas, 75216-7167, United States
VA Northern California Health Care System, Mather, CA

Sacramento, California, 95655-4200, United States
VA Palo Alto Health Care System, Palo Alto, CA

Palo Alto, California, 94304-1290, United States
VA Portland Health Care System, Portland, OR

Portland, Oregon, 97207-2964, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA

Seattle, Washington, 98108, United States
VA Salt Lake City Health Care System, Salt Lake City, UT

Salt Lake City, Utah, 84148, United States
VA San Diego Healthcare System, San Diego, CA

San Diego, California, 92161, United States

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