Bacterial infectious disease

This study tests a new vaccine called VAX-31 in adults aged 50 and older who have already received a pneumonia vaccine. The goal is to see if VAX-31 is safe and triggers a strong immune response. About 752 participants will receive either VAX-31 or an active comparator vaccine, a…

This study tests a new vaccine designed to protect against three common types of Salmonella bacteria that cause serious infections in Sub-Saharan Africa. The trial includes healthy participants ranging from adults down to young infants, and compares the vaccine to a placebo to se…

This study tests a new pneumococcal vaccine (PG4) to see if it is safe and tolerable in adults. About 380 healthy adults will receive either the experimental vaccine, a similar vaccine, a standard vaccine, or a placebo. Participants will be monitored for side effects and give blo…

This early-stage trial tests a new pneumococcal vaccine called PnMAPS30plus in 121 healthy adults aged 50 to 64. Participants receive a single shot of either the new vaccine or an approved one (PCV20) and are monitored for about six months. The goal is to check safety and whether…

This study tests a new vaccine (iNTS-GMMA) designed to prevent severe Salmonella infections caused by two common strains. Researchers are giving the vaccine to healthy adults, children, and infants in Ghana to check if it is safe and triggers a strong immune response. The ultimat…

This study tests a new vaccine called VAX-31 to protect babies against pneumococcal disease, which can cause pneumonia and meningitis. About 900 healthy infants will receive four doses of VAX-31 or an existing vaccine starting at 2 months old. Researchers will check for side effe…

This large phase 3 trial is testing a typhoid conjugate vaccine (Vi-TCV) in 30,000 healthy children aged 9 months to 12 years in Malawi. Half get the typhoid vaccine, half get a meningitis vaccine for comparison. The goal is to see if the typhoid vaccine prevents blood-confirmed …

This Phase 3 study is testing an investigational meningococcal conjugate vaccine (MenACYW) in over 1,600 healthy children and adolescents aged 2 to 17 in China. The vaccine aims to protect against four types of meningococcal bacteria that can cause serious infections like meningi…

This study tests a new Lyme disease vaccine (VLA15) in about 200 healthy adults aged 18 to 44. Participants receive five shots over two years—four of the vaccine and one of salt water—to see if different timing schedules are safe and produce a strong immune response. The goal is …

This early-stage study tests a new vaccine called Ad5-105K to see if it is safe and triggers an immune response against tuberculosis (TB). About 36 healthy adults aged 18 to 49 who have been exposed to TB bacteria (but have no active disease) will receive either the vaccine or a …

This phase II trial tests a new tuberculosis vaccine called MTBVAC (BBV169) in 164 healthy adolescents and adults. Some participants get the new vaccine, others get the standard BCG vaccine. The study checks how safe the vaccine is and how well it triggers an immune response, aim…

This study tests new versions of a vaccine to prevent severe diarrhea caused by the C. diff germ. Healthy adults aged 50 and older who have never had a C. diff infection will receive either a new vaccine formula, a previously studied formula, or a placebo. The goal is to see whic…

This phase 2 trial is testing a new pneumococcal vaccine (PG4) in about 605 healthy infants to see if it is safe and triggers a strong immune response. Infants will receive four doses starting at 2 months old, and the new vaccine will be compared to existing vaccines like Prevnar…

This large study tests an experimental vaccine called M72/AS01E-4 to see if it can prevent tuberculosis (TB) in teens and adults. About 20,000 people will receive either the vaccine or a placebo. The goal is to find a safe and effective way to stop TB, a serious lung infection.

This study looks at how effective the Prevnar 20 (PCV20) vaccine is at preventing serious lung infections in people aged 65 and older. Researchers will analyze medical records from over 22 million Medicare beneficiaries, comparing those who got the vaccine to those who did not. T…

This study tests a new vaccine (PCV21) that protects against 21 types of pneumonia-causing bacteria. About 1,700 healthy infants will receive either the new vaccine or an existing one alongside their routine shots. The goal is to see if the new vaccine is safe and helps babies bu…

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This phase 3 study tests whether a new 21-valent pneumococcal vaccine (PCV21) is safe for healthy infants. About 2360 babies will receive either PCV21 or the current Prevnar 20 vaccine at 2, 4, 6, and 12-15 months old. Researchers will monitor for side effects like injection-site…

This study is testing a new vaccine called MenABCWY that aims to protect against five types of meningococcal bacteria, which can cause serious infections like meningitis. Around 312 healthy teenagers will receive two doses of the vaccine on different schedules to see how safe it …

This study tests a new vaccine called Shigella4V2 to see if it can protect people from shigellosis, a severe diarrheal disease. About 120 healthy adults will receive either the vaccine or a placebo and then be exposed to the bacteria in a controlled setting. The goal is to see if…

This study tests the MenB+OMV NZ vaccine in 50 healthy infants starting at 2 months old in South Korea. The vaccine is given as three shots over about a year to see if it triggers a strong immune response against meningococcal group B bacteria, which can cause meningitis. Researc…

This study tests a two-dose vaccine designed to prevent diarrhea from two common types of Shigella bacteria in 8,000 children aged 6 months to 5 years in Bangladesh. Half the children get the vaccine, half get a placebo, and researchers track who gets sick over time. The goal is …

This study tests an experimental nasal vaccine made from a harmless virus (Sendai virus) that is similar to the one causing croup. The goal is to see if it is safe and helps children ages 1 to 5 build protection against croup. About 54 children will receive the vaccine as nose dr…

This study tests two experimental vaccines (BNT164a1 and BNT164b1) to see if they are safe and trigger an immune response against tuberculosis. About 500 healthy adults who have already received the BCG vaccine will receive three doses of either a vaccine or a placebo. The goal i…

This study monitors the safety of the PREVENAR 20 vaccine in 1,100 infants aged 2 to 6 months in Japan. Infants receive four doses as part of routine care, and researchers track any side effects. The goal is to ensure the vaccine is safe for widespread use.

This study tests a new vaccine that protects against 20 types of pneumococcal bacteria, which can cause pneumonia and other infections. Around 200 healthy Chinese adults, children, and infants will receive the vaccine to see if it is safe and how well it triggers an immune respon…

This study looks at how well a pneumonia vaccine (PCV20) works in people who have recovered from B-cell lymphoma and were treated with anti-CD20 therapy. Researchers want to see if a single dose or a boosted dose is safer and more effective at preventing pneumococcal infections. …

This study tests a new vaccine called H107e/CAF®10b to prevent tuberculosis (TB). It is the first time this vaccine is given to people. The trial involves 140 healthy adults aged 18 to 45 and checks for side effects and how well the vaccine triggers the immune system. The goal is…

This study tests a vaccine designed to protect young children from four types of meningitis bacteria. Researchers gave the vaccine to 660 toddlers aged 6 to 23 months and will check their immune response over time. Some children will also receive a booster shot at age 3 to see if…

This study tests a new 21-valent pneumococcal conjugate vaccine (PCV21) in about 1,092 healthy infants and toddlers. The goal is to see if PCV21 is safe and helps the body produce antibodies against pneumococcal bacteria better than the current licensed vaccine. Participants rece…

This study tests an anthrax vaccine called AV7909 in 220 healthy adults aged 18 to 65. The goal is to see how safe it is and how well it triggers the immune system, using two different dosing schedules and booster shots at 6 and 12 months. Participants will be monitored for side …

This Phase 3 study tests whether mixing a new 21-valent pneumococcal vaccine with a licensed 20-valent version is safe and helps build immunity in healthy infants. About 580 babies will receive different combinations of the vaccines at routine checkups. The goal is to see if flex…

This study tests a new pentavalent meningococcal vaccine (MenPenta) that aims to protect against five types of meningococcal bacteria (A, B, C, W, Y) in healthy children, toddlers, and infants. Researchers will compare it to existing licensed vaccines and check how well it works …

This early-stage trial is testing a new vaccine called PCV24, designed to protect children against 24 types of pneumococcal bacteria. The study involves 230 healthy children aged 6 weeks to 17 years and will check for side effects and measure immune response. The vaccine is given…

This phase II trial tests a new 24-valent pneumococcal conjugate vaccine (PCV24) in 992 adults aged 18 and older. The study aims to check the vaccine's safety and how well it triggers an immune response compared to an existing 23-valent vaccine. Participants receive one dose of e…

This study tests a new vaccine designed to prevent Group B Streptococcus (GBS) infections, which can cause serious illness in newborns. About 600 healthy, non-pregnant women aged 18-49 in the US and South Africa will receive either the vaccine or a placebo. Researchers will check…

This study tests a new 21-valent pneumococcal vaccine (PCV21) in healthy infants, toddlers, children, and adolescents who need catch-up vaccination. Around 1,268 participants will receive either PCV21 or the current 20-valent vaccine. Researchers will monitor side effects and mea…

This study reviews medical records of about 2,700 pregnant women in Thailand who received the Pertagen® whooping cough vaccine and their babies. Researchers want to see if the vaccine is linked to any delivery complications or health issues in newborns. The goal is to confirm the…

This large Phase 3 trial is testing the safety of a new recombinant pertussis (whooping cough) vaccine in 2,399 healthy adults aged 18 to 75. Participants receive a single booster dose, and researchers monitor for side effects over 28 days. The goal is to confirm the vaccine is s…

This phase 3 study tests a new vaccine (DTacP) that protects infants from diphtheria, tetanus, and whooping cough. Around 2,900 healthy babies aged 2-3 months will receive the vaccine to check its safety and how well it triggers immunity. The trial compares different schedules an…

This Phase 2 trial is testing a new vaccine called IVT PCV-25 in healthy infants to see if it is safe and triggers a strong immune response. The vaccine targets 25 types of pneumococcal bacteria, which can cause serious illnesses like pneumonia and meningitis. Around 421 babies w…

This Phase 2 trial tests tibulizumab, a dual-action antibody, in 225 adults with hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses. Participants first receive either the drug or a placebo for 16 weeks, then everyone gets the drug for another 16 wee…

This Phase 2 trial tests whether a new drug called TBAJ-876, or the existing drug bedaquiline, combined with pretomanid and linezolid, can treat drug-sensitive tuberculosis faster and more effectively than the standard 6-month regimen. About 309 adults with newly diagnosed TB are…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This study tests a 4-session behavioral program to reduce alcohol use in 450 people with TB and HIV in India. Unhealthy drinking can worsen TB and HIV outcomes. The program is added to usual care, and researchers will check if it lowers alcohol use and improves health. The goal i…

This study looks at the long-term safety and effectiveness of a drug called sonelokimab for people with moderate to severe hidradenitis suppurativa (HS), a painful skin condition. About 835 adults and teens who completed an earlier sonelokimab study will receive the drug for an e…

This study is testing a single dose of the antibiotic Vabomere in 39 children from birth to under 18 years old who have serious bacterial infections. The goal is to find the right dose and check how safe and tolerable the drug is. All children are hospitalized and receiving other…

This study tests the safety of an antibiotic called Vabomere in children aged 3 months to 12 years who have complicated urinary tract infections, including kidney infections. The children receive the medicine through an IV while in the hospital. Researchers monitor for side effec…

This study tests a special virus called a bacteriophage, combined with standard antibiotics, to treat a severe lung infection caused by Mycobacterium abscessus. The trial involves just one patient and aims to see if the virus can help clear the infection. It is an early, personal…

This study tests a new blood-filtering method called adaptive blood purification (ABP) for people with septic shock. The treatment aims to remove inflammatory substances from the blood. 276 adults in intensive care will be randomly assigned to receive either standard care or stan…

This study looks at whether the antibiotic omadacycline can help people with a hard-to-treat lung infection caused by Mycobacterium abscessus. Researchers will review medical records of 200 patients to see how many get better or are cured. The goal is to find out which patients b…

This study tests a drug called TRL1068 for people with a long-term infection in a hip or knee replacement. The drug works by breaking down the protective layer (biofilm) that bacteria create, making antibiotics more effective. The goal is to cure the infection with a minor proced…

This study tests two different drug combinations to treat Helicobacter pylori, a stomach bacteria that can cause indigestion. About 66 adults with dyspepsia will receive either a triple therapy (amoxicillin, clarithromycin, esomeprazole) or a quadruple therapy (bismuth, metronida…

This study compares a single-stage surgery using implants coated with an antibiotic-loaded hydrogel to the standard two-stage surgery for treating chronic hip prosthesis infections. The single-stage approach aims to remove the infected implant and place a new one in the same oper…

This study tests whether a food supplement called Nyaditum resae® can reduce the gut problems caused by antibiotics used to treat tuberculosis (TB). About 48 adults with new, drug-sensitive TB will take either the supplement or a placebo alongside their regular TB medicines. The …

This study tests a drug called sonelokimab in 35 teenagers aged 12 to 17 with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition that causes painful lumps. The main goals are to see how the drug moves through the body and whether it is safe. Researchers wi…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests a drug called clofazimine for people with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal is to see if adding clofazimine to standard treatment helps clear the bacteria from sputum and improves walking ability and fatigue. About 102…

This study is for women who previously received a vaginal probiotic (LC106) for bacterial vaginosis in an earlier trial. Researchers want to see if the good bacteria from the probiotic can stay in the vagina over time. About 71 women will be followed, and the main goal is to chec…

This pilot study tests a new rinse device (SwishKit) plus standard oral care against standard care alone in 21 intubated ICU patients. The goal is to see if the device reduces harmful bacteria in the mouth and throat, which could lower the risk of lung infections. The study is sm…

This study tests three antibiotic regimens for scrub typhus, a bacterial infection spread by mites. Researchers compare 7 days of doxycycline, 3 days of doxycycline, and 3 days of azithromycin in 177 hospitalized patients aged 15 and older. The goal is to see which treatment clea…

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to either a 5-day or 10-day course, with some receiving a placebo a…

This study tests whether online training and regular feedback reports can help doctors prescribe fewer antibiotics for common infections like ear infections, strep throat, sinusitis, and pneumonia in children. About 420 children aged 6 months to 12 years are included. The goal is…

This study tests whether a fecal transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 children aged 3-21 and track whether the infection comes back.…

This study tests a new blood filtering therapy for adults in the ICU with septic shock, a life-threatening condition caused by severe infection. The treatment aims to remove harmful substances from the blood to help patients recover faster. The trial includes 15 participants and …

This study tests a new combination of five oral drugs (bedaquiline, delamanid, levofloxacin, linezolid, and clofazimine) for treating multidrug-resistant tuberculosis (MDR-TB). The goal is to see if a shorter treatment course (16 to 40 weeks) can effectively cure the infection wi…

This program provides access to the VT-X7 system, which delivers antibiotics directly into the joint through a pump over 7 days, for people with a serious hip or knee infection after joint replacement. It is for patients who have already tried other treatments and have no other o…

This study tests whether taking a probiotic (a 'good' bacteria) can help women who get frequent urinary tract infections (UTIs). About 90 women with a history of repeat UTIs will take either a probiotic or a placebo (a dummy pill) for 6 months. The goal is to see if the probiotic…

This phase II trial tests whether a fecal microbiota transplant (using donor stool) can help eliminate multidrug-resistant organisms (MDROs) from the gut of infected patients. 32 adults with resistant bacterial infections will receive the transplant plus standard antibiotics. The…

This study tests whether giving antibiotics directly into the bone during a standard cleaning surgery can better control joint infections and reduce the need for additional major surgeries. About 100 adults with infected knee or hip replacements will receive this targeted antibio…

This study tests whether a device called the PMX cartridge, which filters endotoxins from the blood, can improve survival in people with septic shock. About 150 adults with severe infections and low blood pressure will receive either standard care alone or standard care plus the …

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening condition where infection causes dangerously low blood pressure. Many patients develop a fast heart rate, which can worsen outcomes. Ivabradine slows the heart without weakening its pump…

This study looks at whether having a nurse case manager helps people with multidrug-resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 patients in South Africa are involved. Half of the clinics have a nurse case manager to guide care, while the oth…

This study tests an oral enzyme called SYN-004 in adults who have received a stem cell transplant and need intravenous antibiotics for fever. The enzyme is designed to break down antibiotics in the gut, protecting the natural bacteria there. Researchers will check safety, whether…

This study tests two strategies for treating septic shock in the emergency department. One group gets less IV fluid and starts blood-pressure-raising drugs (vasopressors) early. The other group gets more IV fluid first, then vasopressors if needed. The trial includes 1000 patient…

This study aimed to see if communities with low levels of trachoma could stop receiving yearly azithromycin treatments without the infection coming back. Researchers planned to compare groups that continued or stopped the medicine over three years. However, the trial was withdraw…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This study planned to test a treatment called MET-2, a mix of gut bacteria, to help clear antibiotic-resistant germs from the body after a bloodstream infection. It was designed for adults not in intensive care who had a resistant infection. The trial was withdrawn before enrolli…

This study tests whether the antibiotic linezolid can effectively treat early syphilis in 24 adults. Participants have primary, secondary, or early latent syphilis, and some also have well-controlled HIV. The main goal is to see if linezolid reduces syphilis infection markers in …

This study compares two types of antibiotic-loaded bone cement used during hip fracture surgery to see which better prevents joint infections. About 7000 patients aged 60 and older with displaced femoral neck fractures will be included. Hospitals are randomly assigned to use eith…

This study looks at whether giving children with acute lymphoblastic leukemia a daily antibiotic called ciprofloxacin can reduce bacterial infections during the first month of chemotherapy. About 313 children in the UK are taking part. The goal is to see if this approach works be…

This study tests a package of community support, family help, digital reminders, and healthcare worker training to improve how tuberculosis is found and treated in South Ethiopia. About 278 patients, family members, and health workers will take part. The goal is to see if this co…

This phase 2 trial tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) works better than the standard 26-week treatment for drug-susceptible tuberculosis. About 94 adults with TB will be randomly assigned to either the short r…

This study tests whether using personalized dosing (based on drug levels in the blood) for the antibiotic teicoplanin works better than standard dosing for treating bacterial infections. About 74 adults in hospital intensive care or other units will take part. The goal is to see …

This early-stage study tests a new lab-made antibody injection against tetanus in 68 healthy adults aged 18-60. The main goal is to check safety and side effects, not to treat or prevent tetanus directly. Participants receive a single shot and are monitored for several weeks.

This study tests a new antibiotic called contezolid against a hard-to-treat lung infection caused by Mycobacterium abscessus. Twenty-four adults will take either contezolid or an older drug, linezolid, for 14 days. Researchers will measure how quickly the drug kills the bacteria …

This study tests a smartphone app and a tablet dashboard for community health workers to support people with both tuberculosis (TB) and HIV in South Africa. The app helps patients stay on track with their medications, while the dashboard alerts health workers if someone needs ext…

This study tests whether adding CAL02 to standard antibiotics helps people with severe community-acquired bacterial pneumonia recover faster. CAL02 is designed to neutralize toxins released by bacteria. About 276 hospitalized adults in critical care will receive either CAL02 or a…

This study tests a 1-month course of three medicines (isoniazid, rifapentine, and vitamin B6) to treat latent tuberculosis in 25 adults with end-stage kidney disease who are candidates for a kidney transplant. The goal is to see if this shorter treatment is safe and easy to compl…

This study compares three modern dental materials used to treat deep cavities in children's permanent molars by preserving the tooth nerve. The goal is to see which material best helps the tooth root continue growing and reduces pain. About 48 healthy children aged 7 to 11 with o…

This study tests whether 7 days of antibiotics works as well as the standard 14 days for treating a serious bloodstream infection caused by Pseudomonas bacteria. About 300 adults who have already received 6 days of treatment will be randomly assigned to stop at 7 days or continue…

This study tests a new antibiotic called omadacycline, taken once a day by mouth, against standard antibiotics for bone and joint infections. About 180 adults with these infections will be randomly assigned to receive either omadacycline or the usual care. The goal is to see if o…

This study looks at how a medicine called BAT® works in children who have or may have been exposed to botulism toxin. The medicine is an antitoxin that helps stop the toxin from causing more harm. Researchers will take blood samples from up to 10 children to see if the dose is ri…

This study compares three dental procedures—pulpotomy, partial pulpotomy, and direct pulp capping—all using a material called MTA, to treat deep cavities in children's baby molars. The goal is to see which technique best preserves the tooth, prevents pain, and avoids infection. T…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study compares two treatments for infected baby molars in children aged 3 to 8: a less invasive method using a triple antibiotic paste versus a standard root canal with a calcium hydroxide-iodoform paste. The goal is to see which approach better relieves pain, swelling, and …

This real-world study is testing two neotetracycline drugs, eravacycline and tigecycline, in 300 adults with drug-resistant Gram-negative bacterial infections. Researchers will track how well the drugs clear the infection and monitor for side effects. The goal is to see if these …

This study tests whether giving higher doses of a TB drug (rifampicin) plus an extra antibiotic (levofloxacin) for 14 days, with or without steroids, can help more people survive. It includes 732 adults with HIV who are hospitalized for TB that has spread beyond the lungs. The go…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This study compares two standard treatments for acute infection after hip or knee replacement: a single surgery to clean the joint versus two planned surgeries. About 490 participants will be randomly assigned to one approach. The goal is to see which method better prevents the n…

This study is testing two tuberculosis (TB) prevention treatments in pregnant women who also have HIV. The goal is to see if these treatments are safe and how they interact with the HIV medication dolutegravir. About 252 pregnant women will take either a daily TB drug for one mon…

This study tests whether a once-weekly combination of two drugs (rifapentine and isoniazid) can safely prevent tuberculosis in children and teens with HIV who are already taking the antiretroviral dolutegravir. About 92 participants aged 3 months to 17 years will receive the TB p…

This early study tests whether transferring a parent's healthy nasal bacteria to their newborn can help prevent staph infections. Researchers will give the baby a nasal spray containing the parent's bacteria or a placebo, then monitor the baby's nose bacteria and safety. The stud…

This study looks at whether a special light-activated dye can kill more bacteria and reduce pain after root canal treatment. Fifty adults with infected teeth will receive either standard care or the light therapy. The goal is to see if this simple addition improves healing and co…

This study tests whether adding a natural substance called lignin to the usual antibiotic treatment helps more people get rid of H. pylori infection. About 70 adults with a first-time H. pylori diagnosis will take either lignin or a placebo daily for two weeks, alongside standard…

This study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This study looks at whether the antibiotic cefiderocol can lower death rates in hospitalized adults with a tough, drug-resistant Acinetobacter infection. Researchers will compare patients who got cefiderocol to those who received the best available treatment. The goal is to see w…

This study tests whether giving antibiotics more often to entire communities can eliminate trachoma, an eye infection that can cause blindness. Over 300,000 people in Ethiopia are taking part. The goal is to see if this intensive approach works better than the current yearly trea…

This study looks at the best time to add the drug vasopressin for people with septic shock—a life-threatening drop in blood pressure from infection. About 2,050 adults will be treated using either an earlier or later threshold for starting vasopressin. The goal is to see which ap…

This study tests whether a higher dose of the oral antibiotic cephalexin can better treat cellulitis, a common skin infection, in adults visiting the emergency room. About 446 participants will receive either a high or standard dose to see if it reduces the need for changing anti…

This study tests whether transferring healthy vaginal bacteria from donors can cure recurrent bacterial vaginosis (BV). Ten women with frequent BV will receive the transplant. The goal is to restore natural balance and prevent repeat infections without antibiotics.

This study tests two calcium silicate-based dental cements, Biodentine and NeoPutty, for treating irreversible pulpitis (severe tooth nerve inflammation) in adults. Sixty participants with deep cavities and spontaneous pain will receive a single-session pulpotomy, where the infla…

This study tests I-FALMIN, a supplement made from toman fish, in 112 adults with pulmonary tuberculosis and low albumin levels. Participants take the supplement or a placebo for one day alongside standard TB treatment. Researchers will check if albumin levels and body mass index …

This study tests whether two new 17-week drug combinations can treat pulmonary tuberculosis as effectively as the standard 6-month regimen. About 288 people with TB will receive one of three daily pill regimens. The goal is to see if shorter treatment can clear the infection fast…

This study tests whether giving two IV antibiotics early, instead of one, can clear Staphylococcus aureus bloodstream infections faster and improve outcomes. About 300 hospitalized adults will be randomly assigned to receive either a single antibiotic or a combination of two. Onc…

This study tests whether adding methotrexate to standard steroid treatment can help people with a painful leprosy complication called ENL. 550 adults with active ENL will receive either methotrexate or a placebo alongside prednisolone. The goal is to see if methotrexate reduces t…

This phase 3 trial is testing a 6-month, all-oral combination of four drugs (bedaquiline, delamanid, linezolid, and levofloxacin or clofazimine) to treat rifampin-resistant tuberculosis in Chinese teenagers and adults aged 12 and older. The goal is to see if this shorter regimen …

This study planned to compare a newer blood test (presepsine) with a standard one (lactate) for diagnosing severe sepsis and septic shock in emergency department patients. The goal was to see if presepsine could detect these life-threatening infections more accurately. However, t…

This study is testing whether a blood test called Monocyte Distribution Width (MDW) can quickly identify patients with bacteria in their blood (bacteremia) in the emergency department. Researchers will observe 50,000 patients who have blood cultures ordered, comparing MDW results…

This study looks at whether a saliva sample can be used instead of a throat swab to diagnose Group A Strep (strep throat) in children. Throat swabs can be uncomfortable, especially for kids, while collecting saliva is much easier. Researchers will compare saliva testing to standa…

This study is testing a new rapid blood test for syphilis that gives results from a fingerstick sample during a single clinic visit. About 600 adults attending a community health centre in Winnipeg will take part. Researchers want to see if this quick test is as accurate as stand…

This study tests a lollipop-shaped device called CandyCollect to see if it can detect strep throat in children ages 5-17. Kids suck on the lollipop for a few minutes, and it captures bacteria in special channels. Researchers compare results to standard throat swabs to see if the …

This study evaluates a new blood test called Xpert Tropical Fever that can quickly detect several tropical diseases like malaria, dengue, and Zika from a small blood sample. Researchers will enroll 2,500 people with fever symptoms to see how accurate the test is compared to stand…

This study looks at 174 adults with painful joint replacements who may have a chronic infection. Researchers are testing a combination of advanced lab tests, imaging, and tissue sampling to see which methods best detect the infection. The goal is to create a more reliable diagnos…

This study evaluates a new blood test that aims to directly detect the bacteria causing dormant tuberculosis (TB), rather than relying on the body's immune response. Current tests cannot tell if treatment worked or who will develop active TB, leading to unnecessary antibiotics. R…

This study tests a finger-clasp device called Lab Clasp that measures lactate from fluid just under the skin, similar to a pulse oximeter. Researchers want to see if it matches standard blood tests in 6 healthy adults. If it works, it could make sepsis monitoring easier and less …

This study evaluates a new test called the QIAstat-Dx cUTI Plus AMR Panel, which aims to quickly detect bacteria and antibiotic resistance in urine samples from people with suspected complicated urinary tract infections (cUTI). Researchers will enroll 1500 participants of all age…

This study evaluates a new PCR test (Bioneer Q-RFIA kit) for quickly and accurately detecting tuberculosis (TB) and resistance to key antibiotics. About 2,350 adults with TB symptoms will provide samples to see how well the test works compared to standard methods. The goal is to …

This study in Pakistan compares two new TB diagnostic tests (Pluslife MTBC and Ustar PortNAT) to the standard Xpert Ultra test. Researchers will collect tongue swabs and sputum from 6,100 people screened for TB. The goal is to see if the new tests are accurate, faster, and easier…

This study tests a new vaccine called VAX-31, which protects against 31 types of pneumonia-causing bacteria. It is given together with the seasonal flu shot to healthy adults aged 50 and older. The goal is to see if giving both vaccines at the same time is safe and works as well …

This study tests whether the meningitis vaccine Bexsero can also prevent gonorrhea, a common sexually transmitted infection. About 2,600 adults aged 18-50 who are at higher risk for gonorrhea will receive either the vaccine or a placebo. Researchers will track how many get infect…

This study tests whether taking doxycycline before potential exposure to STIs works better than taking it after exposure. 300 men who have sex with men will be randomly assigned to one of two groups and followed for 2 years. The goal is to see which approach better prevents chlam…

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This study looks at better ways to find and prevent tuberculosis (TB) in people living with HIV. Researchers will test a new screening method and offer patients a choice of TB preventive medicines with extra support like text reminders. The goal is to improve TB detection and hel…

This Phase 3 study is testing a new vaccine called VAX-31 in about 4,000 healthy adults aged 50 and older. The goal is to see if VAX-31 provides better immune protection against more strains of pneumococcal bacteria compared to two current vaccines, Prevnar 20 and Capvaxive. Rese…

This early-stage study tests whether a single injection of a new antibody, JST-010, is safe in healthy adults aged 18 to 55. The goal is to prevent pneumonic plague, a rare but serious lung infection. Researchers compare the antibody to a placebo and monitor participants for one …

This Phase 3 trial tests whether a meningitis B vaccine (Bexsero) can prevent gonorrhea infections in men who have sex with men. 150 participants in Hong Kong will receive either the vaccine or a placebo. Researchers will compare infection rates and monitor safety.

This study was designed to see if treating a common stomach bacteria (H. pylori) along with using a stomach acid drug could prevent ulcers caused by low-dose aspirin. It planned to enroll adults with heart or artery disease who needed long-term aspirin therapy. However, the study…

This study screens 500 adults in South Florida for H. pylori, a stomach infection that can lead to chronic gastritis, ulcers, and gastric cancer. Those who test positive receive free treatment with a three-drug combination (VOQUEZNA® Triple Pak®) for 14 days. The goal is to see i…

This study screens people in South Florida for H. pylori, a stomach infection that can lead to chronic gastritis, ulcers, and even stomach cancer. Those who test positive receive treatment, and the study compares at-home breath testing versus in-person retesting to confirm the in…

This study tests whether taking two TB prevention drugs daily for one month works as well as taking them weekly for three months. It includes 1,000 people with HIV or those living with someone recently diagnosed with TB. The goal is to see which schedule more people complete and …

This study tests whether giving patients their own preserved stool (collected before a stem cell transplant) can prevent Clostridium difficile infection afterward. About 59 adults receiving an allogeneic stem cell transplant are randomly assigned to get the stool transplant or st…

This study aimed to find out if checking pregnant women for bacterial vaginosis every two weeks could reduce the chance of early delivery. It planned to include women with a history of preterm birth. However, the trial was withdrawn before any participants were enrolled, so no re…

Multiple myeloma patients are at high risk for serious bacterial infections like pneumonia. This study at National Taiwan University Hospital will give 101 patients either one or two doses of the PCV13 pneumonia vaccine to see which schedule is safer and boosts immunity better. R…

This study tests whether freezing fat cells (cryolipolysis) works better for cellulite when combined with a minor procedure that cuts the fibrous bands pulling down the skin (subcision). Fifteen healthy women with moderate to severe cellulite on both outer thighs will receive one…

This study tests whether using cold or laser-activated fluids during a root canal can reduce pain and kill more bacteria than standard treatment. Sixty adults with an infected lower molar will receive one of four rinses: room-temperature, cold, heated, or laser-activated sodium h…

This study tests whether taking vitamin D3 before a root canal can reduce pain afterward. Fifty-four adults with low vitamin D and painful tooth inflammation will receive either a single high dose, a three-day course, or a placebo. Pain levels and painkiller use will be tracked f…

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study looks at whether rinsing with a green tea extract (EGCG) during a tooth-saving procedure (pulpotomy) can lower pain and improve success rates in adults with severe tooth decay. 64 participants with deep cavities will receive one of two rinses and one of two filling mat…

This study tests two ways to clean a tooth during a root canal: laser-activated irrigation and passive ultrasonic irrigation. Researchers want to see which method leads to less pain and better quality of life afterward. 90 adults with infected or damaged permanent teeth are takin…

This study looks at pain after root canal treatment in adults with a tooth condition called irreversible pulpitis. Researchers are testing three different sealers (materials used to fill the root canal) to see which one leads to the least pain and need for painkillers. 75 partici…

This study looks at whether applying cold therapy (cryotherapy) during a pulpotomy—a procedure to save a decayed tooth—can lower pain and improve quality of life afterward. About 82 adults with severe tooth pain will be treated, and their pain levels and daily comfort will be tra…

This study looks at different ways to clean a tooth during a root canal to see which causes the least pain and improves quality of life. 90 adults with a specific type of tooth infection will be randomly assigned to one of three irrigation methods. They will report their pain lev…

This study tests whether a single injection of dexamethasone (a steroid) near the tooth can reduce pain after root canal treatment for people with severe, irreversible tooth inflammation. 44 adults with this condition will receive either the steroid or a placebo (salt water) inje…

This study looks at whether using cold, hot, or ultrasound-activated rinsing solutions can lower pain and bacteria after a root canal. Sixty adults with painful tooth pulp inflammation will receive one of four rinsing methods. The goal is to find which approach works best for a m…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study investigates whether a blood test can detect the bacteria that cause tuberculosis (TB) in people with active TB and their asymptomatic household contacts. Researchers in Uganda will use several methods, including a DNA-based test, to look for TB bacteria in blood sampl…

This observational study looks back at 22,000 adults in Sweden diagnosed with infective endocarditis, a serious heart valve infection, since 1997. By linking national health records, researchers aim to understand which patients benefit most from valve surgery and what factors aff…

This study looks at how HIV infection and aging impact the body's response to the Prevnar 13 vaccine, which protects against pneumococcal bacteria. Researchers will measure antibody levels in the lungs, nasal passages, and blood of participants aged 21-45 or 55-75, comparing thos…

This study tracks 56 follicular lymphoma patients to see how long their COVID-19 and other vaccine immunity lasts while they receive chemotherapy and maintenance therapy. Researchers will collect blood samples at several time points to measure immune responses. The goal is to und…

This study looks at whether having close contact with pets can help keep your gut healthy while taking antibiotics and lower the risk of a serious infection called C. difficile. Researchers will follow 200 adults getting dental implants who need antibiotics, checking their gut ba…

This study in India will test a low-cost urine check (IsoScreen) on 900 adults being treated for tuberculosis. The test detects whether they have taken their medication recently. Researchers want to see if the test can reliably find people who are missing doses, so that doctors c…

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This study looks at genetic changes in people with H. pylori infection or stomach cancer to understand how the infection can lead to cancer. Researchers will analyze tissue samples from 110 adults undergoing endoscopy. The goal is to find early warning signs and possible ways to …

This study gathers 35-50 international critical care experts to agree on how to classify and manage septic shock using point-of-care ultrasound. The goal is to create consensus statements that could help personalize treatment. No patients are enrolled; instead, experts complete s…

This study screens adults interested in fecal microbiota transplant (FMT) for Clostridium difficile infection. Researchers will collect medical information and run basic health tests to create a database of potential participants. The goal is to make it faster and easier to enrol…

This study is tracking over 2,200 tuberculosis patients to see how the amount of TB drugs in their blood relates to how well the treatment works and whether they have side effects. By measuring drug levels, researchers hope to find ways to adjust doses for each person, especially…

This study aimed to measure brain blood flow and oxygen levels in critically ill patients with septic shock, and to see how common treatments like fluids and blood transfusions affect them. The researchers planned to use ultrasound to monitor blood flow in the brain. However, the…

This study follows 28 kidney transplant recipients who are switching from one anti-rejection drug (anticalcineurin) to another (belatacept). Researchers want to see how this change affects the immune system's ability to fight the common CMV virus. Participants will have blood tes…

This study looks at how the size of root canal preparation and the amount of remaining tooth structure affect the survival of treated lower molars. Sixty patients with infected pulp will receive either a conventional or conservative root canal preparation. Researchers will track …

This study looks at 109 people in Virginia with nontuberculous mycobacterial (NTM) lung disease. Researchers use genetic sequencing to tell if a repeat infection is a relapse or a new infection from the environment. The goal is to better understand how the disease comes back and …

This study looks at how tuberculosis (TB) medications travel through a mother's body, into her breastmilk, and to her nursing baby. Researchers will take blood and milk samples from 20 mothers and small blood samples from their infants at several time points after a dose. The goa…

This study tests whether AI-powered X-ray analysis and portable molecular tests can help find tuberculosis (TB) and COVID-19 cases in African communities where many cases go undetected. Over 26,000 adults will be screened using these tools, and researchers will measure how quickl…

This study looks at whether a booster dose of the acellular pertussis vaccine (Tdap-IPV) can reduce the amount of whooping cough bacteria in the nose after intentional exposure. Healthy adults who were vaccinated as children will receive either the Tdap-IPV booster or a control v…

This study tests a computer tool that uses maps and location data to help infection preventionists find and stop hospital-acquired infections faster. About 25 infection prevention staff will use the tool and report how easy it is to use and whether it helps them respond more quic…

This study follows 500 children under 18 who tested positive for flu, RSV, or COVID-19. Each child takes a daily nose swab for 14 days to measure how the virus levels change over time. Researchers also check if family members get sick. The goal is to understand when kids are most…

This study compares two methods for measuring root canal length during root canal treatment: a manual technique using hand instruments and a machine-assisted mechanical technique. Both methods use electronic devices called apex locators to improve accuracy. About 104 adults needi…

This study looks at whether giving the BCG vaccine as a mist breathed into the lungs works better than the usual injection under the skin. It includes 36 healthy adults who have already had BCG, some with type 2 diabetes and some without. Researchers will measure immune responses…

This study looks at small molecules called microRNAs in the blood of people with sepsis, a severe bloodstream infection. Researchers want to see if changes in these molecules can help predict who will survive. About 150 participants will provide blood samples, and their microRNA …

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study at St. Jude Children's Research Hospital is testing whether a next-generation DNA test can predict bloodstream infections in children and teens with cancer who are at high risk. Current methods often detect infections too late, leading to severe illness or death. The g…

This study is using electronic medical records from about 365,000 pregnant women in the U.S. to check the safety of the Adacel vaccine, which protects against tetanus, diphtheria, and whooping cough. Researchers will compare pregnancy and birth outcomes between women who got the …

This study planned to compare how often women get urinary tract infections after giving birth, depending on whether they had a catheter during labour. It aimed to include pregnant women at 37 weeks or more. However, the study was withdrawn before enrolling any participants, so no…

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study looks at how sepsis, a severe infection, can cause heart problems in intensive care patients. Researchers will collect data, blood samples, and heart ultrasound images from 330 adults with septic shock. The goal is to find patterns that help doctors better diagnose and…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study is looking for genes that might make some people more likely to get an infection after hip or knee replacement surgery. Researchers will collect blood or saliva samples from 150 people in families with a history of such infections, plus unaffected relatives. The goal i…

This study follows 100 adults hospitalized in intensive care units with severe pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how many survive. They will also check for antibiotic resi…

This study measures how hot the inside of a tooth gets when dentists shave off a tiny bit of enamel (a common step before braces). Researchers will test two different tools on 40 teeth from 30 people to see which method causes less heat. Keeping the tooth cool is important becaus…

This study tests a new microfluidic device that uses a very small blood sample to measure how well immune cells (neutrophils) function in premature newborns. The goal is to see if this test can predict which babies will develop sepsis, a life-threatening infection. Researchers wi…

This study aimed to find the best length of time for patients to take antibiotics after surgery for an infected joint replacement. It planned to compare different antibiotic durations to see which works best to prevent the infection from coming back and to avoid antibiotic resist…

This study was designed to observe how antibiotics work in patients with knee replacement infections. Researchers planned to measure antibiotic levels in joint fluid after placing a medicated spacer. The study was withdrawn before enrolling any participants, so no results or conc…

This study looks at 50 children with septic shock who receive early continuous renal replacement therapy (CRRT), a type of blood filtering. Researchers want to see if early CRRT helps stabilize blood pressure, reduce organ damage, and improve recovery. The goal is to gather infor…

This study looks back at the medical records of 150 children treated for tuberculosis at a French hospital. The goal is to see how many were cured, how many had problems, and why some treatments failed. By understanding these patterns, doctors hope to improve care for children wi…

This study tests whether using rapid, advanced lab tests to identify the exact bacteria causing a severe infection can help doctors choose the right antibiotics faster. About 190 adults with sepsis in Greek ICUs will either get standard care or the new testing strategy. The goal …

This study looks at a new method for checking infected wounds. Researchers want to see if putting wound samples into blood culture bottles finds bacteria better than the usual lab method. 300 patients with infected wounds took part. The goal is to improve how we detect wound infe…

This study tests a 'discharge stewardship bundle' to help doctors prescribe the right antibiotics for the right duration when children leave the hospital. Over 1,100 children with pneumonia, urinary tract infections, or skin infections will be followed. Doctors receive feedback r…

This study in Nepal tests whether using rapid point-of-care tests for sexually transmitted infections can reduce the overuse of antibiotics for vaginal discharge. About 1,500 women will be split into three groups: standard care, test-guided treatment, or test-guided treatment plu…

This study was designed to track how the immune system recovers after CAR-T cell therapy and to test a pneumococcal vaccine (PCV-21) in these patients. It planned to enroll 50 adults with blood cancers or solid tumors. However, the study was withdrawn before any participants were…

This study tests whether temperature sensors placed inside a Venturi mask can monitor breathing patterns in 82 patients hospitalized with pneumonia and respiratory failure. The goal is to see if these patterns can detect early signs of deterioration before patients need a breathi…

This study aimed to see if the BCG vaccine, given as a skin injection, could stop the TB bacteria from growing in healthy adults. Researchers planned to vaccinate some volunteers and then expose them to a weakened form of TB six months later to measure protection. However, the tr…

This study tests the safety of a new tuberculosis vaccine called ID93/GLA-SE in 48 healthy adults, some of whom have had the standard BCG vaccine before. Researchers will also use an experimental method where a weakened form of TB bacteria is given as an aerosol to see how the im…

This study looks at how the antibiotic cefazolin behaves in the blood of people on chronic hemodialysis who have catheter infections. Researchers will take blood samples at different times to measure drug levels. The goal is to find the best dose to treat infections while avoidin…

This study looks at why people with bone cancer (skeletal sarcoma) get more infections after joint replacement surgery than those with arthritis. Researchers will collect tissue and blood samples from 40 patients to compare immune and bacterial factors. The goal is to understand …

This study looks at whether taking an oral typhoid vaccine temporarily makes the gut more 'leaky' and how the immune system responds. Ten healthy adults will receive the vaccine and a low-dose aspirin challenge. Researchers will measure sugar levels in urine and immune cells in b…

This study looks at whether a person's genetic makeup influences how well a dental treatment called vital pulp therapy works for saving teeth with pulpitis (tooth nerve inflammation). Researchers will collect saliva from 96 participants to analyze specific genes, then track treat…

This study aims to understand how nontuberculous mycobacteria (NTM) spread among people with cystic fibrosis (CF). NTM infections are hard to treat and common in CF, but their sources are unclear. Researchers will track 100 participants with CF and NTM, testing dust and water in …

This study was designed to see if taking activated charcoal could help clear certain blood thinners (rivaroxaban, apixaban) faster in patients needing an urgent procedure. It planned to enroll 140 adults and measure how quickly the drug left their blood. However, the trial was wi…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study looks back at medical records of about 5,000 people with a serious bloodstream infection caused by a common bacterium. Researchers compare two antibiotic treatments to see which one leads to better survival and fewer side effects. The goal is to find out if a newer opt…

This study looks back at hospital records of more than 31,000 people with septic shock in Catalonia, Spain, from 2018 to 2023. Researchers want to understand how common it is, who gets it, and why death rates differ between hospitals. The goal is to find patterns that can lead to…

This study looks at data from two previous clinical trials involving 369 patients with Staphylococcus aureus bloodstream infections. Researchers want to see if adding the antibiotic fosfomycin to standard care helps certain patient groups more than others. They will classify pati…

This study tests whether a 3-minute educational video can help more people complete their treatment for latent tuberculosis (LTBI). About 1,898 adults at Kaiser Permanente Southern California are randomly assigned to receive the video or standard care. The main goal is to see if …

This study follows 2,500 people who visit freshwater beaches in Ontario, Manitoba, and Nova Scotia to see if contact with water containing blue-green algae (cyanobacteria) leads to stomach bugs, respiratory issues, or skin/eye infections. Researchers will also track illness in pe…

This study looks at whether certain inflammation markers in the blood can predict how well dental numbing shots work and how much pain people feel after treatment. Researchers will analyze blood samples from 150 adults with tooth inflammation (irreversible pulpitis) and compare t…

This study examines how the COVID-19 pandemic affected syphilis cases and their interaction with HIV. Researchers will review medical records of 240 adults diagnosed with syphilis in Italy between 2017 and 2025. The goal is to see if pandemic restrictions led to delayed diagnoses…