Can a vaginal probiotic stick around? new study follows women who got the treatment

NCT ID NCT07305844

ENROLLING_BY_INVITATION Disease control Sponsor: Caroline Mitchell Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for women who previously received a vaginal probiotic (LC106) for bacterial vaginosis in an earlier trial. Researchers want to see if the good bacteria from the probiotic can stay in the vagina over time. About 71 women will be followed, and the main goal is to check if the probiotic bacteria are still present at meaningful levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LC106 (a vaginal tablet containing 6 strains of Lactobacillus crispatus)
What this could lead to: If successful, this could show that the probiotic consistently colonizes the vagina, pointing toward a way to restore healthy bacteria and reduce recurrent bacterial vaginosis.
What could go wrong: This is a very early (Phase 1), small, open-label study with no placebo group, so results may not prove effectiveness. The probiotic may not colonize as expected or could cause irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial vaginosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTERIAL VAGINOSIS

Contacts and locations

Locations

CAPRISA

Vulindlela, South Africa
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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