Can a probiotic shield kids from antibiotic side effects?

NCT ID NCT07015736

Ongoing Disease control Sponsor: Eskisehir Osmangazi University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spread of antibiotic-resistant genes. One hundred children will receive either the antibiotic alone or with the probiotic for 10 to 21 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Saccharomyces boulardii CNCM I-745 (a probiotic yeast)
What this could lead to: If it works, this could show that taking a probiotic alongside antibiotics helps prevent diarrhea and keeps the gut microbiome healthy in children.
What could go wrong: This is a small, early-phase study with only 100 children, so results may not apply to everyone. The probiotic might not reduce diarrhea or could cause side effects like bloating.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis infectious otitis media otitis media sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE OTITIS MEDIA ACUTE SINUSITIS ANTIBIOTIC-ASSOCIATED DIARRHEA

Contacts and locations

Locations

Acibadem Univsersity Faculty of Medicine

Istanbul, Turkey (Türkiye)
Eskisehir Osmangazi University

Eskişehir, 26040, Turkey (Türkiye)
Sancaktepe Şehit Prof.Dr. İlhan Varank Training and Research Hospital

Istanbul, Turkey (Türkiye)
Şişli Hamidiye Etfal Training and Research Hospital

Istanbul, Turkey (Türkiye)

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