Numbing ear drops could ease children's ear infection pain faster

NCT ID NCT05651633

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial tests whether adding lidocaine ear drops to standard painkillers provides better ear pain relief for children aged 1–6 with acute otitis media. Half the children receive the ear drops plus usual care (oral painkillers, with or without antibiotics), while the other half receive usual care alone. Parents track their child's pain over three days to see if the drops make a meaningful difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
lidocaine hydrochloride ear drops (Otalgan)
What this could lead to
If effective, adding lidocaine ear drops to standard painkillers could offer faster, more complete ear pain relief for children with ear infections, reducing distress and antibiotic use.
What could go wrong
This is a small trial (29 children) and the benefit over usual care may be modest or not statistically significant. Ear drops cannot be used if the eardrum is perforated, and side effects like local irritation are possible.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University Medical Center Utrecht

    Utrecht, Utrecht, 3584 CX, Netherlands

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