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New study aims to safely prevent TB in pregnant women with HIV

NCT ID NCT05122026

Ongoing Disease control Sponsor: The Aurum Institute NPC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing two tuberculosis (TB) prevention treatments in pregnant women who also have HIV. The goal is to see if these treatments are safe and how they interact with the HIV medication dolutegravir. About 252 pregnant women will take either a daily TB drug for one month or a weekly dose for three months. The study will monitor for side effects and check drug levels in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
isoniazid and rifapentine
What this could lead to
If successful, this could provide a safe way to prevent tuberculosis in pregnant women with HIV without compromising their HIV treatment.
What could go wrong
This is an early-phase study with only 252 participants, so results may not apply to all pregnant women. There is a risk of side effects like liver problems or drug interactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease HIV Seropositivity latent tuberculosis infection tuberculosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV SEROPOSITIVITY PREGNANCY TUBERCULOSIS INFECTION

Contacts and locations

Locations

  • FAMily Centre for Research with Ubuntu (FAMCRU)

    Cape Town, Cape Town, 7505, South Africa

  • Peri Natal HIV Research Unit - Klerksdorp Tshepong Hospital

    Klerksdorp, North West, 2571, South Africa

  • The Aurum Institute: Tembisa Clinical Research Centre

    Tembisa, Gauteng, 1632, South Africa

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