Virus vs. superbug: experimental therapy targets Drug-Resistant lung infection

NCT ID NCT07228702

ENROLLING_BY_INVITATION Disease control Sponsor: Vancouver Coastal Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a special virus called a bacteriophage, combined with standard antibiotics, to treat a severe lung infection caused by Mycobacterium abscessus. The trial involves just one patient and aims to see if the virus can help clear the infection. It is an early, personalized approach for a condition that is very hard to treat.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mycobacteriophage Muddy_HRMN0052 (a virus that attacks bacteria) plus standard antibiotics (amikacin, clofazimine, bedaquiline, linezolid)
What this could lead to: If it works, this could point toward a new treatment option for people with stubborn lung infections that don't respond to standard antibiotics.
What could go wrong: This is a very early study in just one person, so results may not apply to others. The treatment may not work, and there are risks from both the phage and the strong antibiotics.

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Conditions

The condition(s) this trial relates to.

lung disorder mycobacterial infectious disease Mycobacterium Infections, Nontuberculous pneumonia pulmonary non-tuberculous mycobacterial infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYCOBACTERIUM ABSCESSUS INFECTION NON-TUBERCULOUS MYCOBACTERIAL (NTM) PNEUMONIA

Contacts and locations

Locations

Vancouver General Hospital Non-Tuberculous Mycobacterial Disease Clinic

Vancouver, British Columbia, V5Z 1M9, Canada

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