Could donor bacteria beat recurring vaginal infections?
NCT ID NCT04517487
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether transferring vaginal fluid from healthy donors can help people with recurrent bacterial vaginosis (BV) that doesn't respond well to antibiotics. Participants receive either the donor fluid or a placebo (saline) to see if the transplant restores a healthier vaginal microbiome and eases symptoms like discharge and odor. The study includes 30 adults aged 18-50 with a history of frequent BV episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vaginal fluid from healthy donors, introduced into the vagina to replace disease-associated bacteria
- What this could lead to
- If it works, this could offer a new option for people with stubborn, recurring bacterial vaginosis that antibiotics don't fix.
- What could go wrong
- This is an early-stage trial with only 30 participants, so results may not apply broadly. Risks include infection or the transplant not taking hold.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hadassah Medical Center
Jerusalem, 9765422, Israel
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