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Could a pill stop lyme disease before it starts? new trial underway

NCT ID NCT07562087

Recruiting now Prevention Sponsor: Tarsus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen May 03, 2026 · Last updated Jun 23, 2026 · Updated 10 times

Summary

This study tests a pill called TP-05 (lotilaner) to see if it can prevent Lyme disease in healthy adults who are often around ticks. About 700 participants will receive either a low dose, high dose, or placebo. The main goal is to check safety and how the drug moves through the body, with a secondary look at whether it stops infection.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-••••

Locations

  • Study Site

    RECRUITING

    Pikesville, Maryland, 21208, United States

  • Study Site

    RECRUITING

    Brookline, Massachusetts, 02445, United States

  • Study Site

    RECRUITING

    Fall River, Massachusetts, 02723, United States

  • Study Site

    RECRUITING

    Minneapolis, Minnesota, 55402, United States

  • Study Site

    RECRUITING

    Marlboro, New Jersey, 07746, United States

  • Study Site

    RECRUITING

    Albany, New York, 12205, United States

  • Study Site

    RECRUITING

    Binghamton, New York, 13905, United States

  • Study Site

    RECRUITING

    Buffalo, New York, 14217, United States

  • Study Site

    RECRUITING

    East Syracuse, New York, 13057, United States

  • Study Site

    RECRUITING

    Middletown, New York, 10941, United States

  • Study Site

    RECRUITING

    New York, New York, 10036, United States

  • Study Site

    RECRUITING

    Rochester, New York, 14609, United States

  • Study Site

    RECRUITING

    Erie, Pennsylvania, 16508, United States

  • Study Site

    RECRUITING

    Hatboro, Pennsylvania, 19040, United States

  • Study Site

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Study Site

    RECRUITING

    Pittsburgh, Pennsylvania, 15236, United States

  • Study Site

    RECRUITING

    Pottstown, Pennsylvania, 19464, United States

  • Study Site

    RECRUITING

    West Chester, Pennsylvania, 19380, United States

  • Study Site

    RECRUITING

    Warwick, Rhode Island, 02886, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

TP-05 (lotilaner) pills

What this could lead to

If it works, this could be a new pill that prevents Lyme disease after a tick bite, reducing the need for tick checks and antibiotics.

What could go wrong

This is an early phase 2b trial focused on safety and dosing, not yet proven to prevent Lyme. The drug may cause side effects or fail to show benefit.

Conditions

The condition(s) this trial relates to.

Bacterial Infections and Mycoses bacterial infectious disease Borrelia infectious disease gram-negative bacterial infections Infections spirochaetales infections tick-borne infectious disease vector-borne disease Lyme disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYME DISEASE