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Could a single pill stop lyme disease before it starts?

NCT ID NCT07562087

Ongoing Prevention Sponsor: Tarsus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests a new pill called TP-05 (lotilaner) to see if it can prevent Lyme disease in healthy adults who are often around ticks. The pill is already used in pets to kill ticks. Researchers will give either a low dose, high dose, or placebo to 700 volunteers and watch for side effects and how well it works. The goal is to find a safe, easy way to stop Lyme disease before it takes hold.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
TP-05 (lotilaner) pills
What this could lead to
If it works, this could lead to a pill that prevents Lyme disease after a tick bite, reducing the need for antibiotics and worry.
What could go wrong
This is an early phase 2b trial, so it may not prove effective. The drug is already used in animals, but safety and dosing in humans are still being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bacterial Infections and Mycoses bacterial infectious disease Borrelia infectious disease gram-negative bacterial infections Infections spirochaetales infections tick-borne infectious disease vector-borne disease Lyme disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYME DISEASE

Contacts and locations

Locations

  • Study Site

    Pikesville, Maryland, 21208, United States

  • Study Site

    Brookline, Massachusetts, 02445, United States

  • Study Site

    Fall River, Massachusetts, 02723, United States

  • Study Site

    Minneapolis, Minnesota, 55402, United States

  • Study Site

    Marlboro, New Jersey, 07746, United States

  • Study Site

    Albany, New York, 12205, United States

  • Study Site

    Binghamton, New York, 13905, United States

  • Study Site

    Buffalo, New York, 14217, United States

  • Study Site

    East Syracuse, New York, 13057, United States

  • Study Site

    Middletown, New York, 10941, United States

  • Study Site

    New York, New York, 10036, United States

  • Study Site

    Rochester, New York, 14609, United States

  • Study Site

    Erie, Pennsylvania, 16508, United States

  • Study Site

    Hatboro, Pennsylvania, 19040, United States

  • Study Site

    Philadelphia, Pennsylvania, 19107, United States

  • Study Site

    Pittsburgh, Pennsylvania, 15236, United States

  • Study Site

    Pottstown, Pennsylvania, 19464, United States

  • Study Site

    West Chester, Pennsylvania, 19380, United States

  • Study Site

    Warwick, Rhode Island, 02886, United States

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