Spirochaetales infections

This study tests an experimental mRNA vaccine (mRNA-1982) designed to prevent Lyme disease, which is spread by tick bites. About 350 healthy adults aged 18 to 70 will receive either the vaccine or a placebo to check for safety and immune response. The goal is to find the best dos…

This study tests whether a fifth dose of Pfizer's Lyme disease vaccine (VLA15) is safe and boosts immunity in people who already received four doses. About 1,700 healthy volunteers aged 7 and older will get either the vaccine or a saltwater shot. Researchers will compare side eff…

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This study is testing whether a drug called tadalafil (often used for erectile dysfunction) combined with a home cycling program can help boys with Duchenne muscular dystrophy. The drug aims to improve blood flow to muscles, which is often poor in DMD, while exercise builds stren…

This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This trial is testing whether a 7-day course of doxycycline works as well as the standard 14-day course for people with multiple erythema migrans, a sign of early Lyme disease. About 200 participants will be randomly assigned to one of the two treatment durations. Researchers wil…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether plasma transfusion and a blood-filtering procedure called hemoperfusion can prevent lung damage and death in people with leptospirosis, a bacterial infection spread by animals. Researchers will also check if a blood marker called CFI can predict who will …

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests a micropulse laser for diabetic macular edema, a condition causing vision loss in people with diabetes. Fifty participants with initial or stubborn swelling will receive the laser treatment. Researchers will measure changes in vision and retinal thickness to see …

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This trial tests two strategies to control sexually transmitted infections (STIs) among 2,900 cisgender men who have sex with men in Kenya. One group gets a single dose of antibiotics every few months (WHO-recommended periodic presumptive treatment), another takes doxycycline wit…

This study tests whether adding doxycycline to the standard penicillin shot works better for treating early syphilis in people with HIV. About 688 adults will be randomly assigned to get either penicillin alone or penicillin plus a week of doxycycline pills. The main goal is to s…

This study aims to increase syphilis testing and treatment for pregnant women who haven't had prenatal care or a syphilis test during their pregnancy. Researchers will offer rapid point-of-care tests in the emergency department and obstetrical triage, then help connect those who …

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This study aims to develop a better blood test for early Lyme disease in children. Current tests often miss early infections or give false positives. Researchers will also study the immune response and the types of Lyme bacteria involved. About 500 children with suspected Lyme di…

This study is testing two new blood test kits designed to diagnose syphilis. Researchers will collect blood samples from 1000 people, including those with symptoms, those at high risk, and healthy controls. The goal is to see how accurate these new kits are compared to standard l…

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study tests a new device called MagIA H3S that can screen for HIV, hepatitis B, hepatitis C, and syphilis using a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab tests. If it …

This study checks if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results to lab tests. The study also looks at how peer support can help homeless people in Toronto get tested and tre…

This study is testing a new rapid test for syphilis that uses a fingerstick blood sample, giving results quickly at the clinic. Researchers want to see if this quick test is as accurate as the standard lab test. About 1,300 people visiting the Ottawa Sexual Health Clinic who need…

This study is testing two new molecular tests (qPCR and TMA) to detect syphilis in pregnant women and their newborns. Researchers will compare these tests to current CDC guidelines to see if they are more accurate. The goal is to improve diagnosis and prevent congenital syphilis,…

This study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third tri…

This study tests a new pill called TP-05 (lotilaner) to see if it can prevent Lyme disease in healthy adults who are often around ticks. The pill is already used in pets to kill ticks. Researchers will give either a low dose, high dose, or placebo to 700 volunteers and watch for …

This study tests whether taking the antibiotic doxycycline can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in adolescent and young adult females. About 760 participants aged 13-29 who have had an STI in the past year and recent…

This study tests whether taking the antibiotic doxycycline shortly after sex can prevent bacterial STIs like syphilis, gonorrhea, and chlamydia. It involves 200 men, transgender women, and travestis in Rio de Janeiro who are at higher risk. Participants choose whether to use doxy…

This study tests whether taking a single 200 mg dose of doxycycline within 24–72 hours after unprotected sex can prevent gonorrhea, chlamydia, and syphilis in men who have sex with men. Researchers in Bangkok will enroll 400 participants and follow them for 12 weeks. If effective…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study tests a small, non-invasive device that gently stimulates a nerve in the ear (taVNS) to see if it is safe and tolerable for people with persistent symptoms after Lyme disease treatment. The trial will enroll 24 adults who still have symptoms like fatigue or pain months…

This study tests a new way to treat brain fog in people with post-treatment Lyme disease. Participants will play computer-based thinking games at home while receiving either real or fake brain stimulation (tDCS) for 4 weeks. Researchers will check if the active stimulation improv…

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This study investigates whether the bacteria causing Lyme disease can survive antibiotic treatment and cause ongoing symptoms. Researchers will follow 700 participants, including those with chronic Lyme disease, recovered individuals, and healthy volunteers, using blood tests, sp…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study explores the real-life experiences of people who had Lyme disease during or before pregnancy and are now raising children. Participants fill out surveys about their health, mental well-being, and child development, then take part in an interview to share their personal…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study follows 500 people with active Lyme disease to learn more about the infection. Participants receive standard FDA-approved treatments and undergo tests like blood draws and leukapheresis. The goal is to explore biological markers, track clinical outcomes, and understand…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study looks at how healthy people's skin and immune system respond to tick bites. Researchers will place clean, lab-bred ticks on volunteers' skin and take small skin samples and blood to track changes. The goal is to understand tick resistance and help design future vaccine…

This study looks at whether what patients expect before treatment for early Lyme disease (a red rash called erythema migrans) influences how well they recover. Researchers will follow 200 patients for up to a year, checking for lingering symptoms and comparing them to healthy peo…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study aims to understand how syphilis bacteria spread from people without visible symptoms, focusing on women and men who have sex with women only—groups often overlooked in past research. Researchers will collect swabs and blood samples from 480 participants with early syph…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study looks at how two antibiotics, ceftriaxone and benzathine penicillin G, are processed by the body during pregnancy. Up to 78 pregnant women in the U.S. will take one of these drugs as part of their regular care, and researchers will measure drug levels in their blood. T…

This early-stage study is testing whether a single dose of an experimental antibiotic combination (sulopenem etzadroxil plus probenecid) is safe and tolerable in 12 adolescents already receiving standard antibiotics for a bacterial infection. Researchers will measure how the drug…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study looks at cases of severe Lyme disease (disseminated borreliosis) in patients who have received anti-CD20 therapy, a type of immune-suppressing treatment. Researchers want to describe the symptoms, severity, and progression of the infection in these patients. The study …

This study looks back at cases of recurrent borreliosis, a bacterial infection spread by ticks or lice, diagnosed in France between 2013 and 2025. Researchers will describe the symptoms, where patients got infected, which Borrelia species caused the illness, and how it was diagno…

This study creates a global registry to collect information from 200 people with leptospirosis, a bacterial infection caught from animals or contaminated water. Researchers will track how the disease spreads, what treatments work, and why some patients get very sick. No new treat…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…