Can plasma transfusion and blood filtering save lives in leptospirosis?

NCT ID NCT07127718

Recruiting now Disease control Sponsor: National Kidney and Transplant Institute, Philippines Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether plasma transfusion and a blood-filtering procedure called hemoperfusion can prevent lung damage and death in people with leptospirosis, a bacterial infection spread by animals. Researchers will also check if a blood marker called CFI can predict who will get severe complications. About 678 participants will receive either standard care or one of the experimental treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Plasma transfusion and hemoperfusion
What this could lead to: If successful, this could provide new treatments to prevent severe lung damage and improve survival in leptospirosis patients.
What could go wrong: This is a Phase 2 trial, so the treatments are still experimental. They may not work better than standard care, and there are risks like allergic reactions or bleeding from plasma transfusion.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leptospirosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEPTOSPIROSIS

Contacts and locations

Locations

Institute of Human Genetics, National Institutes of Health - University of the Philippines Manila
ACTIVE_NOT_RECRUITING

Manila, National Capital Region, 1000, Philippines
National Kidney and Transplant Institute
RECRUITING

Quezon City, National Capital Region, 1100, Philippines
San Lazaro Hospital
RECRUITING

Manila, National Capital Region, 1003, Philippines

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