Spirochaetales infections

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tested two new mRNA vaccine candidates designed to prevent Lyme disease. It involved 807 healthy adults to see if the vaccines were safe and if they triggered a good immune response against the bacteria that causes Lyme. The study compared different doses of the vaccin…

This study tested a new vaccine (VLA15) to prevent Lyme disease, a tick-borne illness. About 12,500 healthy people aged 5 and older in high-risk areas received either the vaccine or a placebo. The goal was to see if the vaccine safely reduces Lyme disease cases compared to no vac…

This study tested a new vaccine called VLA15 to prevent Lyme disease, which is spread by tick bites. Researchers gave the vaccine or a placebo to 625 healthy people aged 5 to 65. The goal was to check safety and how well the vaccine triggers an immune response. Results showed the…

This study tested whether a new Lyme disease vaccine (VLA15) is safe for healthy children ages 5 to 17. Over 3,500 kids received either the vaccine or a placebo (saltwater shot) and were monitored for about 2 years. The main goal was to check for side effects like pain, redness, …

This trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study checked how well a new rapid test (Reveal TP) detects syphilis compared to standard lab tests. About 600 adults visiting a Vancouver STI clinic took part. The goal was to see if the quick finger-prick test is accurate enough for routine use.

This study tested a strategy of using rapid, point-of-care diagnostic tests for sexually transmitted infections (STIs) in pregnant women attending antenatal clinics in Zimbabwe. Over 1,000 women were offered testing for chlamydia, gonorrhea, trichomoniasis, syphilis, and hepatiti…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested a short in-class education program to teach children aged 7-12 how to prevent Lyme disease. The program covered personal protection, early detection, and reducing ticks around homes. Researchers compared Lyme disease cases and prevention behaviors between groups…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This study looks at whether people who had leptospirosis, a bacterial infection spread by animals, may have health problems that last for years after the initial illness. Researchers in Reunion will follow about 200 patients who were previously hospitalized with the disease, chec…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…