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Could a pill replace the syphilis shot? new trial tests oral antibiotic

NCT ID NCT05069974

Completed Disease control Sponsor: Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assigned to receive either linezolid pills for 5–10 days or a single penicillin shot. The study tracks whether sores heal and blood tests show the infection is cleared.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Linezolid
What this could lead to
If it works, this could offer an oral alternative to painful penicillin injections for syphilis, especially for patients with penicillin allergies.
What could go wrong
This is a Phase 3 trial, but linezolid is not yet proven for syphilis in humans. It may be less effective than penicillin or cause side effects like nerve damage or bone marrow suppression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

latent early syphilis latent syphilis primary syphilis secondary syphilis syphilis Treponema infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY LATENT SYPHILIS PRIMARY SYPHILIS SECONDARY SYPHILIS

Contacts and locations

Locations

  • Barcelona Checkpoint

    Barcelona, 08015, Spain

  • CAP Drassanes-Hospital Universitari Vall d'Hebron

    Barcelona, 08001, Spain

  • Hospital 12 de Octubre

    Madrid, Spain

  • Hospital Clínic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Germans Trias Pujol

    Barcelona, 08916, Spain

  • Mortimer Market Centre

    London, United Kingdom