Lyme study seeks answers for lingering symptoms

NCT ID NCT00001539

First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 25 times

Summary

This study aims to understand why some people continue to have symptoms after being treated for Lyme disease. Researchers will compare patients with chronic Lyme symptoms to healthy volunteers and other groups using blood tests, spinal taps, and brain scans. The goal is to find out if the Lyme bacteria can survive antibiotics and cause ongoing illness, which could lead to better diagnosis and future treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could lead to better diagnostic tests and clearer criteria for post-treatment Lyme disease syndrome, potentially guiding future treatment trials.

What could go wrong

This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results may take years to translate into clinical practice.

Conditions

The condition(s) this trial relates to.

Lyme disease tick-borne infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.