New vaccine combo could simplify infant shots

NCT ID NCT06824181

Ongoing ⭐️ VACCINE ⭐️ Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tests whether mixing a new 21-valent pneumococcal vaccine with a licensed 20-valent version is safe and helps build immunity in healthy infants. About 580 babies will receive different combinations of the vaccines at routine checkups. The goal is to see if flexible schedules work as well as the standard series.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 21-valent pneumococcal conjugate vaccine (PCV21) and 20-valent pneumococcal conjugate vaccine (Prevnar 20)
What this could lead to: If successful, this could show that mixing different pneumococcal vaccines is safe and effective, potentially offering more flexible vaccination schedules for infants.
What could go wrong: This is a Phase 3 trial, but results may not apply to all populations. The study is still ongoing, and the final outcomes on safety and immune response are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pneumococcal infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMOCOCCAL IMMUNIZATION

Contacts and locations

Locations

Atlantis Clinical Research- Site Number : 8400009

Miami, Florida, 33173, United States
Carolina Family Care - Charleston- Site Number : 8400014

Charleston, South Carolina, 29414, United States
Clinsearch Inc at Dr. Gala, LLC- Site Number : 8400027

Miami, Florida, 33135, United States
Clinsearch Inc at VAST Clinical Research- Site Number : 8400028

Euless, Texas, 76040, United States
DM Clinical Research - Houston - Jones Road- Site Number : 8400012

Houston, Texas, 77065, United States
Finger Lakes Medical Research - Cortland- Site Number : 8400022

Cortland, New York, 13045, United States
Helios Clinical Research - BUR PEDI- Site Number : 8400016

Burleson, Texas, 76028, United States
Investigational Site Number : 1520001

Santiago, Reg Metropolitana de Santiago, 8880465, Chile
Investigational Site Number : 1520002

Santiago, Reg Metropolitana de Santiago, 8380418, Chile
Investigational Site Number : 1520003

Santiago, Reg Metropolitana de Santiago, 8330034, Chile
Investigational Site Number : 4840001

Mexico City, Mexico City, 04530, Mexico
Investigational Site Number : 4840002

Temixco, Morelos, 62587, Mexico
Investigational Site Number : 4840003

León, Guanajuato, 37320, Mexico
Investigational Site Number : 4840004

Tlaltizapán, Morelos, 62770, Mexico
Investigational Site Number : 6080001

Cebu City, 6000, Philippines
Investigational Site Number : 6080002

Quezon City, 1100, Philippines
Investigational Site Number : 6080003

Quezon City, 1121, Philippines
Javara - Privia Medical Group North Texas - Stephenville- Site Number : 8400024

Stephenville, Texas, 76401, United States
Kaiser Permanente - Los Angeles Medical Center- Site Number : 8400025

Los Angeles, California, 90027, United States
Kid's Way Pediatrics- Site Number : 8400013

Hermitage, Pennsylvania, 16148, United States
Private Practice - Dr. Michael W. Simon- Site Number : 8400001

Lexington, Kentucky, 40517, United States
SUNY Upstate Medical University - Syracuse- Site Number : 8400015

Syracuse, New York, 13210, United States
The Medici Medical Research- Site Number : 8400008

Hollywood, Florida, 33021, United States
University of Rochester Medical Center- Site Number : 8400019

Rochester, New York, 14642, United States
University of Texas Medical Branch at Galveston- Site Number : 8400005

League City, Texas, 77555, United States
Velocity Clinical Research - New Orleans- Site Number : 8400006

New Orleans, Louisiana, 70119, United States
Velocity Clinical Research - Sioux City- Site Number : 8400007

Sioux City, Iowa, 51106, United States

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