One surgery enough? trial tests if extra procedure helps fight joint infections
NCT ID NCT05640336
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares two standard treatments for acute infection after hip or knee replacement: a single surgery to clean the joint versus two planned surgeries. About 490 participants will be randomly assigned to one approach. The goal is to see which method better prevents the need for further surgery within one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Surgical debridement (cleaning out infected tissue) and antibiotics
What this could lead to
If successful, this could show that a single surgery is as effective as two planned surgeries for treating joint infections, reducing patient burden and healthcare costs.
What could go wrong
This is a relatively early-stage trial with 490 participants, and results may not apply to all patients. There is a risk of infection returning regardless of the approach.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
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Mayo Clinic Minnesota
Rochester, Minnesota, 55905, United States