One surgery enough? trial tests if extra procedure helps fight joint infections

NCT ID NCT05640336

ENROLLING_BY_INVITATION Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares two standard treatments for acute infection after hip or knee replacement: a single surgery to clean the joint versus two planned surgeries. About 490 participants will be randomly assigned to one approach. The goal is to see which method better prevents the need for further surgery within one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Surgical debridement (cleaning out infected tissue) and antibiotics
What this could lead to: If successful, this could show that a single surgery is as effective as two planned surgeries for treating joint infections, reducing patient burden and healthcare costs.
What could go wrong: This is a relatively early-stage trial with 490 participants, and results may not apply to all patients. There is a risk of infection returning regardless of the approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periprosthetic joint infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPROSTHETIC JOINT INFECTION

Contacts and locations

Locations

Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic Minnesota

Rochester, Minnesota, 55905, United States

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