Can a new TB vaccine protect children with HIV?

NCT ID NCT05539989

NEW Terminated ⭐️ VACCINE ⭐️ Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial is testing two tuberculosis (TB) vaccines—VPM1002 and a repeat BCG vaccination—in pre-adolescents aged 8-14 who were vaccinated at birth. The goal is to see if these vaccines are safe and trigger a strong immune response in children both with and without HIV, and in those who have been exposed to TB bacteria. The study compares the vaccines against a placebo to measure their effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VPM1002 vaccine or BCG revaccination
What this could lead to: If successful, this could lead to a safer and more effective TB vaccine for children, especially those living with HIV, potentially reducing TB cases worldwide.
What could go wrong: This is an early-stage trial, so the vaccines may not prove safe or immunogenic in this population. Results may not generalize to other age groups or regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fungal infectious disease HIV infectious disease tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS TUBERCULOSIS

Contacts and locations

Locations

Desmond Tutu TB Centre - Stellenbosch University (SU) CRS

Cape Town, Western Cape, South Africa
Emavundleni CRS

Cape Town, Western Cape, South Africa
Family Clinical Research Unit (FAM-CRU) CRS

Tygerberg Hills, South Africa
Isipingo CRS

Soshanguve, KwaZulu-Natal, South Africa
Klerksdorp CRS

Klerksdorp, North West, South Africa
Setshaba Research Centre CRS

Soshanguve, Gauteng, South Africa
Soweto IMPAACT CRS

Johannesburg, Gauteng, 1862, South Africa
Umlazi CRS

Durban, South Africa
Wits RHI Shandukani Research CRS

Johannesburg, South Africa

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