New Toxin-Neutralizing drug could speed recovery from severe pneumonia

NCT ID NCT05776004

Ongoing Disease control Sponsor: Eagle Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding CAL02 to standard antibiotics helps people with severe community-acquired bacterial pneumonia recover faster. CAL02 is designed to neutralize toxins released by bacteria. About 276 hospitalized adults in critical care will receive either CAL02 or a placebo, and researchers will measure how quickly they get better and any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CAL02 (a mixture of liposomes that neutralize bacterial toxins)
What this could lead to: If it works, CAL02 could become a new add-on treatment to help people with severe bacterial pneumonia recover faster and spend less time in intensive care.
What could go wrong: This is a mid-stage trial with 276 participants, so results are not yet proven. The drug may not improve outcomes or could cause side effects like infusion reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMONIA, BACTERIAL

Contacts and locations

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Locations

Bekes Varmegyei Kozponti K6rhaz

Gyula, Hungary
Bihor County Emergency Clinical Hospital

Oradea, Romania
Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatov

Szentpeteri Kapu, Hungary
C.H.U de Santiago de Compostela

Santiago de Compostela, Spain
CHD Vendee

La Roche-sur-Yon, Vendee, France
CHU Angers

Angers, France
CHU de Nantes

Nantes, France
Centre Hospitalier Bretagne Atlantique

Vannes, France
Centre Hospitalier Victor Dupouy

Argenteuil, France
Centre Hospitalier de Dieppe

Dieppe, France
Centre Hospitalier de Melun-Senart

Melun, France
Centro de Investigacion Clinica de la Costa SAS

Barranquilla, Colombia
Chu-Ucl-Namur

Yvoir, Belgium
Cleveland Clinic Fairview Hospital

Cleveland, Ohio, 44111, United States
Clinica Ricardo Palma

Lima, Peru
Clinica San Pablo-Sede Surco

Lima, Peru
Clinique Saint Pierre

Ottignies, Belgium
Clinique Universitaire Saint Luc

Brussels, Belgium
Cluj County Emergency Clinical Hospital

Cluj-Napoca, Romania
Dr JM Engelbrecht Trial Site

Somerset West, 7130, South Africa
Elias University Emergency Hospital

Bucharest, Romania
FCRN Clinical Trial Centre

Vereeniging, Gauteng, 1935, South Africa
Foothills Hospital Medical Centre

Calgary, Alberta, Canada
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

São José do Rio Preto, São Paulo, 15090, Brazil
Fundacion Cardioinfantil - Instituto de Cardiologia

Bogotá, Colombia
Fundeni Clinical Institute

Bucharest, Romania
Helen Joseph Academic Hospital

Johannesburg, Gauteng, South Africa
Hopital Nord Franche Comte

Belfort, France
Hopital Raymond Poincare

Garches, France
Hopitaux Universitaires de Strasbourg - Nouvel Hopital Civil

Strasbourg, France
Hospital Central

Mendoza, Argentina
Hospital Clinico San Carlos

Madrid, Spain
Hospital Clínico Universitario de Valladolid

Valladolid, Spain
Hospital Dupuytren

Limoges, France
Hospital Fleyriat

Bourg-en-Bresse, France
Hospital Interzonal General de Agudo Dr Jose Pena

Bahía Blanca, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina
Hospital Mae de Deus

Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Hospital Misericordia Nuevo Siglo

Córdoba, Argentina
Hospital Nacional Edgardo Rebagliati

Lima, Peru
Hospital Nacional III

Arequipa, Peru
Hospital Universitari Mutua Terrassa

Terrassa, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario Dr Peset

Valencia, Spain
Hospital Universitario Infanta Leonor

Madrid, Spain
Hospital Universitario de Tarragona Joan XXIII

Tarragona, Spain
Hospital Universitario de Toledo

Toledo, Spain
Hospital de la Amistad

Piura, Peru
Hospital do Servidor Publico Estadual

São Paulo, Brazil
Institute for Pulmonary Diseases

Kamenitz, Serbia
JSC Rustavi Central Hospital

Rustavi, 3700, Georgia
Krajska Zdravotni, a.s.

Teplice, Czechia
Krajska Zdravotni, a.s.

Ústí nad Labem, Czechia
LLC Aleksandre Aladashvili Clinic

Tbilisi, 0102, Georgia
LTD Batumi Medical Center

Batumi, 6400, Georgia
LTD N5 Clinical Hospital

Tbilisi, 0197, Georgia
LTD Simon Khechinashvili University Hospital

Tbilisi, 0179, Georgia
LTD Tbilisi Central Hospital

Tbilisi, 0159, Georgia
Liepajas Regional Hospital

Liepāja, Latvia
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Oblastní nemocnice Kolín, a.s., nemocnice Středočeského kraje

Zizkova, Czechia
Parc Tauli Hospital Universitari

Barcelona, Spain
Pauls Stradins Clinical University Hospital

Riga, Latvia
Peter Lougheed Centre

Calgary, Alberta, Canada
Pius Brinzeu County Emergency Clinical Hospital

Timișoara, Judet Timis, Romania
Plateforme de Biologie Hospitalo-Universitaire

Dijon, France
Pole Urgences Medecine Aigue CHU de Grenoble-Alpes

Grenoble, France
Pontificia Universidad Catolica de Chile

Santiago, Chile
Rockyview General Hospital

Calgary, Alberta, Canada
Ryexo Clinical Research

Pretoria, South Africa
Saint Paul's Hospital

Vancouver, Canada
South Health Campus Hospital

Calgary, Alberta, Canada
Szaboles-Szatmar-Bereg Varmegyei Oktatokorhaz

Nyíregyháza, Hungary
The First Medical Center LTD

Tbilisi, 0180, Georgia
Thoracic General Hospital

Athens, Greece
Tygerberg Hospital

Cape Town, South Africa
UCSF Hospital

Fresno, California, 93701, United States
UF Health Shands Hospital

Gainesville, Florida, 32610, United States
Unidade de Pesquisa Clinica da Faculdade de Medicina de Botucatu

Botucatu, Brazil
University Clinical Centre

Kragujevac, Serbia
University Clinical Centre

Niš, Serbia
University Clinical Centre of Serbia

Belgrade, Serbia
University General Hospital

Heraklion, Greece
University General Hospital Attikon

Athens, Greece
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Texas Medical Branch

Galveston, Texas, 77555, United States
Univerzitna nemocnica

Martin, Slovakia
Vidzemes Hospital

Valmiera, Latvia
Wake Forest Baptist Health Hospital

Winston-Salem, North Carolina, 27157, United States
Zala Varmegyei Szent Rafael Korbaz

Zalaegerszeg, Hungary

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