Mystery infections in healthy people: scientists investigate

NCT ID NCT00814827

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiwan will be followed for two years to understand why their bodies can't fight off certain germs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this research could help identify why some otherwise healthy people get serious infections, potentially leading to better diagnosis or targeted treatments.

What could go wrong

This is an observational study, not a treatment trial. It may not directly lead to new therapies, and findings may not apply to all populations.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cryptococcosis herpes zoster histoplasmosis invasive non-typhoidal salmonellosis listeriosis melioidosis miliary tuberculosis Opportunistic Infections opportunistic infectious penicilliosis pulmonary non-tuberculous mycobacterial infection pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Cheng Kung University

    Tainan, Taiwan

  • National Siriraj Hospital, Mahidol Universtiy

    Bangkok, Thailand

  • National Taiwan University

    Taiwan, China

  • Ramathibodi Hospital, Mahidol Universtiy

    Bangkok, Thailand

  • Srinagarind Hospital

    Khon Kaen, 40002, Thailand