New study aims to close TB prevention gaps for HIV patients

NCT ID NCT05342064

Ongoing Prevention Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at better ways to find and prevent tuberculosis (TB) in people living with HIV. Researchers will test a new screening method and offer patients a choice of TB preventive medicines with extra support like text reminders. The goal is to improve TB detection and help more people complete their preventive treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TB preventive therapy (isoniazid or rifapentine) and adherence support (text reminders, phone calls)
What this could lead to: If successful, this could lead to simpler, more effective TB screening and preventive treatment strategies for people with HIV, reducing TB deaths.
What could go wrong: This is an observational and interventional study, not a treatment trial. Results may not apply to all settings, and adherence support may not work for everyone.

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Conditions

The condition(s) this trial relates to.

coinfection HIV infectious disease latent tuberculosis infection tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV COINFECTION TUBERCULOSIS TUBERCULOSIS INFECTION

Contacts and locations

Locations

Baylor College of Medicine Children's Foundation

Mbabane, Eswatini
Baylor College of Medicine Children's Foundation

Maseru, Lesotho
Baylor College of Medicine Children's Foundation

Lilongwe, Malawi
Baylor College of Medicine Children's Foundation

Mbeya, Tanzania
Baylor College of Medicine Children's Foundation

Kampala, Uganda

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